Serum levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in pulp and paper mill workers

Tepper, Allison; Burt, Susan; Piacitelli, Laurie A.; Patterson, Donald G.

doi:10.1016/s0045-6535(97)00455-4

Cited by 12 publications

(9 citation statements)

References 34 publications

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“…The concentrations of PCDD/Fs in blood of municipal waste incinerator (MWI) workers and unexposed controls were 21.9 and 16.8 pg I-TEQ/g lipid, respectively (Schecter et al 1991), while Weistrand et al (1997) reported a mean concentration of 22.5 pg I-TEQ/ g lipid in plasma of persons working with cable incineration and electronic equipment. In turn, Tepper et al (1997) found serum PCDD/F levels of 18.1 pg I-TEQ/g a Only nine workers showed 1-HP levels above the detection limit lipid (low exposure) and 21.2 pg I-TEQ/g lipid (high exposure) in pulp and paper mill workers compared with a concentration of 19.1 pg I-TEQ/g lipid for community residents. Recently, Kumagai et al (2000) did not ®nd signi®cant dierences in the serum mean concentrations of PCDD/Fs in Japanese MWI workers (19.2±28.8 pg I-TEQ/g lipid) and control subjects (22.9±24.5 pg I-TEQ/ g lipid).…”

Section: Discussionmentioning

confidence: 91%

Levels of metals and organic substances in blood and urine of workers at a new hazardous waste incinerator

Domingo¹,

Schuhmacher²,

Agramunt³

et al. 2001

International Archives of Occupational and Environmental Health

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Section: Discussionmentioning

confidence: 91%

Levels of metals and organic substances in blood and urine of workers at a new hazardous waste incinerator

Domingo¹,

Schuhmacher²,

Agramunt³

et al. 2001

International Archives of Occupational and Environmental Health

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“…However, limited studies were undertaken in determining the effect of occupational exposure on PCDD/F levels in blood. No positive correlations were reported for several studies undertaken (Demi et al 1996;Tepper et al 1997;Kumagai et al 2001;Domingo et al 2002;Kim et al 2005). In Korea, Kim et al (2005) reported an average PCDD/F blood concentration in incineration workers of 17.73 pg g À1 lipid weight, which was actually lower than that of the general population (23.52 pg g À1 lipid weight), including men (23.48 pg g À1 lipid weight), and women (19.89 pg g À1 lipid weight).…”

Section: Dioxins Furans and Polychlorinated Biphenylsmentioning

confidence: 97%

Persistent organic pollutants in human blood: A review of global data with a comparison to the Singapore population

Tan

Loganath

Chong

et al. 2008

Toxicological & Environmental Chemistry

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In this manuscript, the levels of persistent organic pollutants (POP) in human blood, as reported worldwide, are reviewed. A decline in blood residues of organochlorine pesticides (OCP) due to restrictions and prohibitions in their use was observed mainly since the second half of the 1970s. However, an increase of flame retardants levels, notably the polybrominated diphenyl ethers (PBDE), in human blood was reported in recent years. To date, no age or gender related trend were reported for brominated flame retardants -probably as a result of only recent exposure to PBDE relative to other POP such as polychlorinated biphenyls (PCB) and pesticides, and the shorter half-lives of PBDE. Blood levels of PBDE of individuals residing in the USA are substantially higher than those reported in Japan, Korea, and Germany. Congener specific profiles also differ in accordance with the prevailing use of different technical PBDE between countries. Higher blood concentrations in the USA may be attributed to the once widespread use of commercial penta-BDE on the North American continent. Preliminary data for POP levels in human blood in Singapore was reported and compared to global data. Generally, pesticide levels in Singapore are comparable to those found in other counties. The sum of 38 PCB congeners was 29 ng g À1 lipid, which was an order of magnitude higher than the sum of seven BDE congeners (2.6 ng g À1 lipid) measured in this study. The PBDE profile was consistent with many other blood studies conducted globally, and suggests a universally similar human exposure pattern to these contaminants.

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“…The average TEQ concentrations of PCDD isomers were 14.91 pg I-TEQ/g lipid, and those of PCDF isomers were 38.51 pg I-TEQ/g lipid in the 10 residents. The characteristic pattern of PCDD/F isomers is closely related with their sources of PCDD/Fs [27][28][29][30] . Further study is needed to investigate relationships between the increased TEQ concentrations of PCDD/F isomers and particular sources.…”

Section: Exposure Assessment Of Pcdd/fs Homologue In Residents Near Tmentioning

confidence: 99%

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

et al. 2003

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Hazardous substances, such as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) also have been detected in Municipal Solid Waste (MSW)and industrial waste incinerators in Korea. In this study, we estimated the exposure status of these hazardous substances and their heath effects in workers and residents near the MSW incinerators and residents near the industrial waste incinerators. We interviewed 13 workers and 16 residents from the area around the two MSW incinerators, and further 10 residents from the area around one industrial waste incinerator, which is suspected to emit higher hazardous substances. During the interview we collected information including sociodemographic information, personal habits, work history, detailed gynecologic and other medical history. Blood samples from 45 subjects were also collected for analysis of PCDDs and PCDFs, which were analyzed by HRGC-HRMS (High Resolution Gas Chromatography -High Resolution Mass Spectrometer). In addition to a questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. Urinary concentrations of 8-OH-dG were determined by in vitro ELISA (JAICA, Fukuroi, Japan). MDA were determined by HPLC using adduct with TBA (thiobarbituric acid). The PCDD/F concentrations in residents from the area around industrial waste incinerator were higher than those in workers and residents from the area around MSW incinerator. The average toxic equivalency (TEQ) concentrations of PCDD/Fs in residents from the area around industrial waste incinerator were 53.4 pg I-TEQs/g lipid. The average TEQ concentrations of PCDD/Fs in workers and residents near MSW incinerator were 12.2 pg I-TEQs/g lipid. Estimated daily intake (EDI) of each person was calculated, and the EDI of all workers and residents near MSW incinerator were within the tolerable daily intake range. But for only 30% of 10 people near the industrial waste incinerator were the EDI within the tolerable daily intake range (1-4 pg I-TEQ/kg bw/day) suggested by WHO (1997). The oxidative stress of residents near the industrial waste incinerator was higher than that in workers and residents from the area around MSW incinerator. This oxidative stress may have been caused by hazardous substances, such as PCDD/Fs emitted by incinerators. The residents from the area around industrial waste incinerator were exposed to hazardous substances such as PCDD/ Fs. Proper protection strategies against these hazardous chemicals are needed.

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Serum levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in pulp and paper mill workers

Cited by 12 publications

References 34 publications

Levels of metals and organic substances in blood and urine of workers at a new hazardous waste incinerator

Levels of metals and organic substances in blood and urine of workers at a new hazardous waste incinerator

Persistent organic pollutants in human blood: A review of global data with a comparison to the Singapore population

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

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