Serum levels of Pentraxin 3 differ significantly at the time of blastocyst transfer depending on implantation success: a pilot study

Freis, Alexander; Horn, K; Göggl, Tamara; Hecht, S.; Roesner, Sabine; Strowitzki, T.; Germeyer, Ariane

doi:10.1007/s00404-018-4769-6

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…The commonly used physiological upper limit (2.0 µg/L) for circulating PTX3 is based on cardiovascular studies including both female and male elderly study subjects [10,41]. However, in later studies with healthy, normal-weight, fertile Caucasian women, PTX3 concentrations have been 1.0 µg/L or less [29,32,33]. PTX3 levels may increase by age [18,42] and obesity [43].…”

Section: The Physiological Level Of Ptx3 In Infertile Womenmentioning

confidence: 99%

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Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Korhonen

Unkila‐Kallio

Alfthan

et al. 2020

Arch Gynecol Obstet

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Purpose Pentraxin 3 (PTX3) is a locally secreted, quicker responsive pro-inflammatory protein than C-reactive protein (CRP). We evaluated the value of PTX3 in the prediction of ovarian hyperstimulation syndrome (OHSS), a severe complication of in vitro fertilization (IVF). Methods This two-year prospective follow-up study included 27 women with uncomplicated IVF-cycles (IVF group) and 31 patients diagnosed with moderate or severe early OHSS (OHSS group). PTX3 was analysed from follicular fluid (FF) and serial blood samples with enzyme-linked immunoassay and CRP with particle-enhanced immunoturbidimetric assay. The value of PTX3 and CRP in detecting OHSS was examined with receiver operating characteristic (ROC) curve analysis and expressed as the area under the curve (AUC). Results The circulating PTX3 level peaked at two days after oocyte pickup (OPU2), and in the OHSS group the level was 1.9 times higher (P = 0.006) than in the IVF group. However, in ROC curve analysis PTX3 (AUC 0.79, best cut off 1.1 µg/L) was not superior to CRP (AUC 0.87; best cut off 9.5 mg/L) in predicting early OHSS. In the IVF group, the FF-PTX3 concentration was 15-20 times higher than in the plasma. PTX3 level at OPU2 correlated with the number of punctured follicles (r = 0.56, n = 22, P = 0.006). Triggering with human chorionic gonadotrophin or early pregnancy had no effect on PTX3 level. Conclusion The elevated PTX3 concentration in OHSS at OPU2, when freeze-all embryos strategy is still possible to consider, indicates that PTX3 level could provide additional benefit in the risk assessment for early OHSS.

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Section: The Physiological Level Of Ptx3 In Infertile Womenmentioning

confidence: 99%

“…One small study has shown unchanged PTX3 concentration between the start of an antagonist IVF cycle and oocyte pick-up (OPU) [28]. In addition, systemic PTX3 level at the time of blastocyst transfer has been indicated as a possible biomarker for IVF success [29].…”

Section: Introductionmentioning

confidence: 99%

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Korhonen

Unkila‐Kallio

Alfthan

et al. 2020

Arch Gynecol Obstet

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“…Significantly higher PTX3 levels were observed in women after vaginal birth vs. caesarean section (11) . Significantly elevated maternal serum levels of PTX3 during in vitro embryo transfer have negative effects on embryo implantation (12) . Elevated blood PTX3 in the first trimester and in placental tissues is also associated with recurrent pregnancy loss (13,14) .…”

Section: Diagnosis Of Fertility Disorders and Pregnancy Pathologymentioning

confidence: 99%

Pentraxin 3 – possible uses in neonatology and paediatrics

Szymkowiak¹,

Surmiak²,

Baumert³

2020

Pediatr Med Rodz

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Pentraxin 3 (PTX3) is a multifunctional acute phase protein belonging to the family of long pentraxins, which is synthesised in numerous cells of the body under the influence of proinflammatory factors and locally at the site of inflammation. Under physiological conditions, PTX3 is stored in neutrophil granules, where there is a constant pool of glycoproteins. Increased pentraxin 3 levels in blood serum are observed as early as 1 hour after a damaging stimulus. Elevation of PTX3 serum levels can be used to diagnose fertility disorders in women as well as in pregnancy pathology, women at risk of pre-eclampsia, gestational diabetes, premature rupture of membrane and preterm delivery. The biological function of PTX3 is not fully understood, especially in the population of newborns and children. So far, no reference values for PTX3 levels in newborns and children have been developed. This protein can be used as a marker of pulmonary hypertension in newborns as well as to assess the degree of respiratory failure in premature infants. In older children, it is useful in the assessment of the severity of meningococcal disease and sepsis as well as in the treatment of childhood asthma. There are studies available in which blood levels of PTX3 significantly correlate with the severity of kidney damage in Henoch–Schönlein macular degeneration in children, and the evaluation of this protein in urine is used to detect renal parenchymal destruction after pyelonephritis.

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“…Pentraxin-3 (PTX-3) is an acute-phase reactant and a member of the pentraxin protein family [13]. Several studies have demonstrated that PTX-3 has an important role in innate immunity, inflammation, implantation, decidualization, and placentation [14,15,16]. It has been determined that PTX-3 is expressed in the receptive endometrium, and trophoblasts have been found to affect PTX-expression in decidua [17].…”

Section: Introductionmentioning

confidence: 99%

Annexin-2, pentraxin-3, and osteopontin expressions in the endometrium of women with idiopathic recurrent pregnancy loss during the implantation window

Şahin¹,

Alataş²,

Özkan³

2020

Journal of Surgery and Medicine

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Serum levels of Pentraxin 3 differ significantly at the time of blastocyst transfer depending on implantation success: a pilot study

Abstract: PTX3 could present as a possible biomarker for ART success. The main limitation of this pilot study is its small sample size that needs validation with a larger study population.

Cited by 3 publications

References 32 publications

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Pentraxin 3 – possible uses in neonatology and paediatrics

Annexin-2, pentraxin-3, and osteopontin expressions in the endometrium of women with idiopathic recurrent pregnancy loss during the implantation window

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