Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Abstract

Background. Subclinical hypothyroidism (sHT) is a condition defined by elevated TSH values with normal levels of free thyroid hormones. Altered metabolic status is one of the consequences of sHT which can affect serum levels of FPG, lipid profile, and nitric oxide which propounds cardiovascular consequences per se. The aim of this study was to determine the possible effects of sHT on nitrite/nitrate levels, as a marker of endothelial performance.Materials and Methods. 50 females were enrolled in this study, 25 women as control group and 25 women as case group (evaluated two times: before and after levothyroxine therapy). Blood samples were collected and levels of FPG, lipid profile components, and nitric oxide were measured spectrophotometrically. The data were analyzed using SPSS version 18 software.Results. The levels of lipid profile (except for TG between before and after group, p < 0.05) and nitric oxide did not differ in groups while FPG was significantly higher in case groups in comparison to control group (p < 0.001). Nitric oxide had no correlations with any of variables except for LDL in after treatment group (p < 0.05 and r = 0.397).Conclusion. Nitric oxide does not have correlation with components of lipid profile (except for LDL) or FPG and has no differences in subclinical hypothyroid patients and control group. Levothyroxine therapy during 2 months cannot alter the levels of nitric oxide in subclinical hypothyroid patients.

Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in Gorgan, Northeastern

“…This condition may ultimately lead to arterial obstruction, blood clot formation and myocardial infarction (MI) or stroke in severe circumstances. Therefore, controlling dietary intake of lipids and serum levels of lipid fractions, particularly cholesterol is an important approach for prevention of diabetic complications (9,10). In addition, elevation of triglyceride (TG) or triacylglycerole is another known risk factor for CVD (11).…”

Relationship between serum nitric oxide of patients with thyroid disorders and metabolic syndrome indices and nitrate concentration of water

“…Hashemi et al measured the levels of fasting blood glucose (FPG), lipid profile components, and nitric oxide by spectrophotometry on 50 women (25 healthy groups and 25 hypothyroid patients). They found that nitric www.nature.com/scientificreports/ oxide was significantly different from LDL in the two groups, but it was not significantly different for other components 54 .…”

Evaluation of the relationship between serum nitric oxide of patients with thyroid disorders and metabolic syndrome indices and nitrate concentration of consuming water in Shiraz: A case-control study

“…Hashemi et al measured the levels of fasting blood glucose (FPG), lipid pro le components, and nitric oxide by spectrophotometry on 50 women (25 healthy groups and 25 hypothyroid patients). They found that nitric oxide was signi cantly different from LDL in the two groups, but it was not signi cantly different for other components (55).…”