“…[28,29], generated by stressed host cells, or exogenous pathogen-associated molecular patterns (PAMPs) [30][31][32] are recognized as being capable of activating the pattern recognition receptors (PRRs) [33] of the immune cells and as promoting the synthesis of inflammation mediators. Thus, any kind of tissue damage (pathogens [34,35], CRT [8,9] etc.) can induce a local [27,36] and systemic inflammatory response through circulating mediators ( Fig.…”