Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk

Wiener, Carolina David; Ferreira, Sharon de Mello; Moreira, Fernanda Pedrotti; Bittencourt, Guilherme; Oliveira, Jacqueline Flores de; Molina, Mariane Lopez; Jansen, Karen; Souza, Luciano Dias de Mattos; Lara, Diogo R.; Portela, Luis Valmor; Silva, Ricardo Azevedo da; Oses, Jean Pierre

doi:10.1016/j.jad.2015.05.067

Cited by 72 publications

(48 citation statements)

References 15 publications

(27 reference statements)

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“…These results together corroborate that NGF is effective in the pathophysiology of schizophrenia 2. Recently, our group has reported an increase in NGF in some other mental disorders, such as MDD, suicide risk, and alcohol abuse disorder,7 thereby presupposing a relevant role of NGF in mental disorders. In this way, our results agree with previous literature data.…”

Section: Discussionsupporting

confidence: 79%

“…Additionally, NGF acts outside of the nervous system, particularly within the neuroendocrine and immune system. Previous studies have evaluated the role of altered NGF in animal and human models and found reduced levels of NGF mainly in subjects with major depression 1–7. NGF has an important role in neuronal survival, differentiation, connectivity, and plasticity during development and adulthood, and when affected by stress, are good candidates for the transduction of the effects of adverse events to changes in brain function 1,8,9.…”

Section: Introductionmentioning

confidence: 99%

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Mental disorders, functional impairment, and nerve growth factor

Salles¹,

Soares²,

Wiener³

et al. 2016

PRBM

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Nerve growth factor (NGF) is an important member of the neurotrophin family and its alteration has been associated with psychiatric disorders. Functionality consists of the activities that an individual can perform, as well as their social participation, which is an important factor in analyzing the carrier living conditions of subjects with psychiatric suffering. Several studies have evaluated functionality in bipolar disorder; however, no studies have evaluated the functionality in other mental disorders. There are also few studies investigating the association between functionality and the biological bases of mental disorders. This study aimed to evaluate the serum NGF levels in psychiatric patients and to verify a possible association between the serum neurotrophic levels and functionality. This was a cross-sectional study with a convenient sample obtained from the Public Mental Health Service from the south of Brazil. The final sample was composed of 286 patients enrolled from July 2013 to October 2014. Data was collected using a sociodemographic questionnaire, and the diagnosis was confirmed using the Mini International Neuropsychiatric Interview (M.I.N.I) and a Functioning Assessment Short Test. The serum NGF levels were determined using the enzyme-linked immunosorbent assay method. Statistical analyses were performed using IBM SPSS Statistic 21.0 software. NGF serum levels were increased significantly in patients with obsessive–compulsive disorder compared with patients with no obsessive–compulsive disorder (P=0.015). An increase in serum NGF levels in generalized anxiety disorder patients was observed compared with patients with no generalized anxiety disorder (P=0.047). NGF was negatively associated with autonomy (P=0.024, r=−0.136), work (P=0.040, r=−0.124), and cognition (P=0.024, r=−0.137), thereby showing that changes in serum levels of NGF are associated with functionality in mental disorders.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Mental disorders, functional impairment, and nerve growth factor

Salles¹,

Soares²,

Wiener³

et al. 2016

PRBM

Self Cite

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“…SORCS3 (Figure 5B) is highly expressed in the CA1 region of the hippocampus, and is involved in synaptic depression and spatial learning ability 56,57 . It is also known to play an important role in protein networks associated with PICK1, NGF, and PDGF-BB 58,59 which have been implicated in ADHD, ASD, MDD, and SCZ [60][61][62][63] . NTM (Figure 5C) regulates the outgrowth of neurites, and is associated with the formation of excitatory synapses 64,65 .…”

Section: Discussionmentioning

confidence: 99%

Detecting Local Genetic Correlations with Scan Statistics

Guo

et al. 2019

Preprint

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Genetic correlation analysis has quickly gained popularity in the past few years and provided insights into the genetic etiology of numerous complex diseases. However, existing approaches oversimplify the shared genetic architecture between different phenotypes and cannot effectively identify precise genetic regions contributing to the genetic correlation. In this work, we introduce LOGODetect, a powerful and efficient statistical method to identify small genome segments harboring local genetic correlation signals. LOGODetect automatically identifies genetic regions showing consistent associations with multiple phenotypes through a scan statistic approach. It uses summary association statistics from genome-wide association studies (GWAS) as input and is robust to sample overlap between studies. Applied to five phenotypically distinct but genetically correlated psychiatric disorders, we identified 49 non-overlapping genome regions associated with multiple disorders, including multiple hub regions showing concordant effects on more than two disorders. Our method addresses critical limitations in existing analytic strategies and may have wide applications in post-GWAS analysis.

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“…A meta-analysis of 21 publications [25] confirmed a statistically significant decrease in the blood level of NGF in depression, which correlated with impairment intensity. It has been suggested that the reduced level of NGF in blood serum should be regarded as a biomarker for major depression [26]. Such a reduction is also observed in patients with bipolar disorder [27] and senile depressions [28].…”

Section: Introductionmentioning

confidence: 99%

Low-Molecular-Weight NGF Mimetic Corrects the Cognitive Deficit and Depression-like Behavior in Experimental Diabetes

Gudasheva

et al. 2017

Acta Naturae

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Based on the comorbidity of diabetes, depression, and dementia and recognizing that a deficiency of the nerve growth factor (NGF) is involved in all of these kinds of pathologies, we studied the effect of the mimetic of dimeric dipeptide NGF loop 4, GK-2, on a model of streptozotocin-induced type 2 diabetes in C57Bl/6 mice. GK-2 [hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine)] was synthesized at the V.V. Zakusov Scientific Research Institute of Pharmacology. The study revealed the ability of GK-2 to ameliorate hyperglycemia induced by streptozotocine (STZ 100 mg/kg i.p.) in C57Bl/6 mice, to restore learning ability in the Morris Water Maze test, and to overcome depression after both intraperitoneal (0.5 mg/kg) and peroral (5 mg/kg) long-term administration. The presence of the listed properties and their preservation in the case of peroral treatment determines the prospects of research. Taking into account the previous findings on the ability of GK-2 to selectively activate PI3K/Akt, these data suggest that Akt-signaling is sufficient for pancreatic beta cell function. GK-2 has been shown to exhibit pronounced neuroprotective activity. The coexistence of neuroprotective and antidiabetic effects is in agreement with the fundamental concept holding that the function of neurons and pancreatic beta cells is controlled by similar mechanisms.

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Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk

Cited by 72 publications

References 15 publications

Mental disorders, functional impairment, and nerve growth factor

Mental disorders, functional impairment, and nerve growth factor

Detecting Local Genetic Correlations with Scan Statistics

Low-Molecular-Weight NGF Mimetic Corrects the Cognitive Deficit and Depression-like Behavior in Experimental Diabetes

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