Serum Levels of MMP-8 and MMP-9 as Markers in Chronic Subdural Hematoma

Su, Gao-Jian; Gao, Jie; Wu, Chu-Wei; Zou, Junfeng; Zhang, Di; Zhu, Dongliang; Lee, Jun; Zhang, Jie-Hua; Huang, Xianjian

doi:10.3390/jcm11040902

Cited by 5 publications

(13 citation statements)

References 31 publications

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“…The concentrations of MMP-8 and MMP-9 in the control (normal) group are shown in Table 4 (p < 0.01). Based on our previous study ( 11 ), the concentration of MMP-8 was significantly higher in the normal group compared to that in both preoperative and postoperative CSDH groups, while that of MMP-9 was significantly lower. All CSDH membranes were immunostained for MMP-8 and MMP-9 in all samples.…”

Section: Resultsmentioning

confidence: 72%

“…Based on our previous study, MMP-8 and MMP-9 may contribute to CSDH pathogenesis in different ways ( 11 ). We found that the MMP-8 concentration was significantly higher in the normal group compared to that in preoperative and postoperative groups, whereas the MMP-9 concentration was significantly lower.…”

Section: Discussionmentioning

confidence: 99%

“…We recruited 50 individuals to the normal group based on our previous study ( 11 ). In addition, the membranes of CSDHs were obtained from 10 patients (eight males and two females) who underwent surgeries at the Shenzhen Second People's Hospital.…”

Section: Methodsmentioning

confidence: 99%

“…Numerous biomarkers have been identified in patients with CSDH, including interleukin (IL)-1, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), matrix metallopeptidase (MMP)-2, and MMP-9 ( 5 , 8 – 10 ). In our previous study, we found that MMP-8 and MMP-9 may play a key role in the pathophysiology of CSDH ( 11 ).…”

Section: Introductionmentioning

confidence: 98%

“…However, there have been few studies on the expression and activity of MMPs in CSDH. Based on our previous study, we used immunohistochemistry to analyze CSDH membranes to determine the possible role of MMP-8 and MMP-9 in the development of CSDH ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma

Zhang

et al. 2022

Front. Neurol.

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To determine the possible role of matrix metallopeptidase (MMP)-8 and MMP-9 in the development of chronic subdural hematoma (CSDH), we investigated their expression in CSDH. In our previous study, we analyzed hematoma fluid and peripheral blood of 83 patients with CSDH, including 17 postoperative patients. Based on these results, we included 50 people in the normal group and analyzed 20 markers in the peripheral blood of each person. In order to identify representative markers, it was assessed by using overall differential gene expression. The concentration of MMP-8 was significantly higher in the normal group than that in the preoperative and postoperative groups. The concentration of MMP-9 was significantly lower in the normal group than in both preoperative and postoperative groups. Immunohistochemistry confirmed the expression of MMP-8 and MMP-9 in CSDH membranes. In conclusion, our results provide evidence of the expression of MMP-8 and MMP-9 in CSDH. In addition, the expression of MMP-8 and MMP-9 suggests angiogenesis in CSDH formation.

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Section: Resultsmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma

Zhang

et al. 2022

Front. Neurol.

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Efficacy of atorvastatin administration after surgery in patients with chronic subdural hematoma

Xu,

Tang,

Liu

et al. 2023

Medicine

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To explore the clinical efficacy of atorvastatin administration after surgery in patients with chronic subdural hematoma. We conducted a retrospective study to analyze the clinical data of patients with chronic subdural hematoma. Patients receiving atorvastatin treatment after surgery were divided into the study group while others were divided into the control group. As the primary outcome, we compared the hematoma recurrence rate. The secondary outcomes were the remaining volume of hematoma and the activities of daily living (Barthel index) score at 3 months after discharge. A total of 53 patients were included in the study: 30 patients in the study group (n = 30) and 23 patients in the control group (n = 23). The baseline clinical data were similar in the 2 groups (P > .05). Four patients had recurrence of hematoma in the study group, while 5 patients had recurrence of hematoma in the control group [4/30 (13.3%) versus 5/23 (21.7%), P = .661] at 3 months after discharge. The mean remaining volume of hematoma was 12.10 ± 8.80 mL in the study group and 17.30 ± 9.50 mL in the control group at 3 months after discharge, respectively. The remaining volume of hematoma in the study group was less than that in the control group (P = .045).The activities of daily living score in the study group were higher than those in the control group (97.83 ± 4.48 vs 94.78 ± 5.73, P = .034) at 3 months after discharge. Atorvastatin administration after surgery barely reduce the recurrence rate of chronic subdural hematoma, however, reduced the remaining volume of hematoma and improved neurological function.

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Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology

Domagała,

Data,

Szyller

et al. 2024

Cells

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A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm, which is characterized by a significant bulge on the vessel surface that may have consequences, such as distention and finally rupture. Abdominal aortic aneurysm (AAA) is a major pathological condition because it affects approximately 8% of elderly men and 1.5% of elderly women. The pathogenesis of AAA involves multiple interlocking mechanisms, including inflammation, immune cell activation, protein degradation and cellular malalignments. The expression of inflammatory factors, such as cytokines and chemokines, induce the infiltration of inflammatory cells into the wall of the aorta, including macrophages, natural killer cells (NK cells) and T and B lymphocytes. Protein degradation occurs with a high expression not only of matrix metalloproteinases (MMPs) but also of neutrophil gelatinase-associated lipocalin (NGAL), interferon gamma (IFN-γ) and chymases. The loss of extracellular matrix (ECM) due to cell apoptosis and phenotype switching reduces tissue density and may contribute to AAA. It is important to consider the key mechanisms of initiating and promoting AAA to achieve better preventative and therapeutic outcomes.

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Serum Levels of MMP-8 and MMP-9 as Markers in Chronic Subdural Hematoma

Cited by 5 publications

References 31 publications

Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma

Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma

Efficacy of atorvastatin administration after surgery in patients with chronic subdural hematoma

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology

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