Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance

Wang, Kexin; Li, Fangna; Deng, Yang; Cao, Zhenzhen; Cui, Yixin; Xu, Kai; Ln, Peng; Sun, Yu

doi:10.12659/msm.915331

Cited by 45 publications

(35 citation statements)

References 24 publications

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“…A total of 150 participants included in the study were divided into three groups. There was no statistically signifi-increase in patients with prediabetes and type 2 diabetes compared to control patients [11,12]. Subfatin induces phosphorylation in the adipocyte tissue and increases insulin sensitivity, and its deficiency was found to cause insulin resistance in adipocyte tissue.…”

Section: Resultsmentioning

confidence: 80%

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan

Cavlı

Doğan

et al. 2020

Endokrynologia Polska

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Introduction: Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aims to evaluate serum Metrnl levels in T2DM patients and determine the relationship between serum Metrnl levels and insulin resistance in these patients. Material and methods: This cross-sectional study was conducted among 150 participants. The study was carried out between June 2019 and December 2019 at the internal medicine outpatient clinic of a tertiary university hospital. The participants were divided into three groups: group 1 (control group, n = 50), group 2 (newly diagnosed T2DM, n = 50), and group 3 (long-standing diagnosed T2DM, n = 50). An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed. Results: There was no statistically significant difference between the gender (p = 0.468) and age (p = 0.067) characteristics of the three groups. The Metrnl (subfatin) levels of the participants were as follows: control group-20.05 (1.56-103.78); newly diagnosed T2DM group-2.62 (1.25-103.78); and long-standing diagnosed T2DM group-2.01 (0.80-19.84) pg/mL. The Metrnl (subfatin) levels of the participants in the control group were higher than in the participants in the newly diagnosed T2DM and long-standing diagnosed T2DM groups (p < 0.001). Subfatin demonstrated a negative correlation with insulin and HOMA-IR in the control group and long-standing diagnosed T2DM group. Conclusions: The subfatin level was found to be higher in the healthy control group than in both diabetic patient groups. Subfatin level showed negative correlation with both insulin level and HOMA index. There was a relationship between subfatin and insulin resistance. Low levels of subfatin in the diabetic patient groups may play a role in the pathogenesis of T2DM by increasing insulin resistance.

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Section: Resultsmentioning

confidence: 80%

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan

Cavlı

Doğan

et al. 2020

Endokrynologia Polska

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“…For instance, Wang et al found that Metrnl levels positively correlated with FBG, post-prandial BG, HbA1c, fasting insulin, and HOMA-IR. The authors regarded that Metrnl elevated the risk of T2DM, independent of insulin resistance [38]. Moreover, experimental studies have shown that Metrnl knockout models developed insulin resistance in response to high-fat diet (HFD); on the contrary, Metrnl overexpression in transgenic mice were able to antagonize it [28,39].…”

Section: Plos Onementioning

confidence: 99%

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

et al. 2020

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Patients diagnosed with polycystic ovary syndrome (PCOS) are at high risk of developing a myriad of endocrinologic and metabolic derailments. Moreover, PCOS is a leading cause of habitual abortion, also known as recurrent pregnancy loss (RPL). Meteorin-like protein (Metrnl) is a newly discovered adipokine with the potential to counteract the metaflammation. This study aimed at determining the associations of serum Metrnl levels with homocysteine, hs-CRP, and some components of metabolic syndrome in PCOS-RPL and infertile PCOS patients.This case-control study was conducted in 120 PCOS patients (60 PCOS-RPL and 60 infertile) and 60 control. Serum hs-CRP and homocysteine were assessed using commercial kits, while adiponectin, Metrnl, FSH, LH, free testosterone and insulin levels were analyzed using ELISA technique. Serum Metrnl levels were found to be lower in PCOS patients when compared to controls (67.98 ± 26.66 vs. 96.47 ± 28.72 pg/mL, P <0.001)). Furthermore, serum adiponectin levels were lower, while free testosterone, fasting insulin, HOMA-IR, homocysteine, and hs-CRP were significantly higher in PCOS group compared to controls. Moreover, serum Metrnl correlated with BMI, adiponectin, and homocysteine in controls, and inversely correlated with FBG, fasting insulin, and HOMA-IR in PCOS group and subgroups. Besides, it inversely correlated with hs-CRP in control, and PCOS group and subgroups. These findings revealed a possible role of Metrnl in the pathogenesis of PCOS and RPL. Nevertheless, there is a necessity for future studies to prove this concept.

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“…Lee reported that serum metrnl levels were significantly lower in newly diagnosed type 2 diabetic patients than in subjects with normal glucose tolerance or prediabetes [12]. In our previously published paper, we showed that the serum levels of metrnl in newly diagnosed type 2 diabetic patients were significantly correlated with the lipid profile, glucose profile, and insulin resistance [13]. In the present study, we aimed to determine whether intravenous administration of metrnl could ameliorate insulitis in NOD mice, as no previous study has focused on this issues.…”

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confidence: 58%

Administration of metrnl delays the onset of diabetes in non-obese diabetic mice

et al. 2021

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Type 1 diabetes is a chronic metabolic disease characterized by hyperglycemia due to progressive destruction of pancreatic beta cells via autoimmune attack. Meteorin-like protein (metrnl) is a secreted protein homologous to the neurotrophin metrn and it is induced after exercise in the skeletal muscle. In our paper published previously, we showed that the serum level of metrnl was significantly correlated with the lipid profile, glucose profile and insulin resistance. In this experiment, we asked whether intravenous administration of metrnl could delay the onset of diabetes in non-obese diabetic (NOD) mice. 4-week-old NOD mice were injected intravenously with metrnl. Blood glucose levels were measured weekly. Insulitis scoring, intraperitoneal glucose tolerance test, adoptive T cell transfer, flow cytometry analysis and real-time PCR were performed to investigate the underlying mechanism. The results showed that intravenous administration of metrnl delayed the onset of diabetes in NOD mice. Histology of pancreas showed a decreased infiltration of leukocytes, which was in association with augmentation of regulatory T cells, suppression of autoreactive T cells and altered cytokine secretion. To sum up, the present study showed that intravenous administration of metrnl ameliorated islet lymphocyte infiltration and modulated immune cell responses, raising the possibility that it might be beneficial in improving islet function clinically.

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Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance

Cited by 45 publications

References 24 publications

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

Administration of metrnl delays the onset of diabetes in non-obese diabetic mice

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