Serum levels of matrix metalloproteinases as prognostic markers for severe dengue with plasma leakage

Srinivasan, Sivasubramanian; Mohandas, Sundhar; Gopalan, Vidya; Govindan, Karthikeyan; Varadarajan, Poovazhagi; Kaveri, Krishnasamy; Ramkumar, K.M.

doi:10.1016/j.yexmp.2022.104821

Cited by 1 publication

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Progression to severe dengue is a feared complication and currently, there is no biomarker proven to reliably predict this progression. Several biomarkers like red blood cell micro-particles, serum chymase levels and matrix metalloproteinases (MMP-2 and MMP-9) have been shown to predict this distinction [ 16 , 27 , 28 ]. Clinical features observed to have a positive association with severe dengue include lethargy, persistent vomiting, abdominal pain, diarrhea, hepatomegaly, severe bleeding, pleural effusion, and ascites [ 29 ].…”

Section: Predictive Factors For Severe Denguementioning

confidence: 99%

Management of Dengue: An Updated Review

2022

View full text Add to dashboard Cite

Dengue is an important public health problem with a wide clinical spectrum. The World Health Organization classifies dengue into probable dengue, dengue with warning signs, and severe dengue. Severe dengue, characterized by plasma leakage, severe bleeding, or organ impairment, entails significant morbidity and mortality if not treated timely. There are no definitive curative medications for dengue; management is supportive. Judicious fluid resuscitation during the critical phase of dengue is the cornerstone of management. Crystalloids are the initial fluid of choice. Prophylactic platelet transfusion is not recommended. Organ involvement in severe dengue should be carefully looked for and managed. Secondary hemophagocytic lymphohistiocytosis is a potentially fatal complication of dengue that needs to be recognized, as specific management with steroids or intravenous immunoglobulin may improve outcomes. Several compounds with anti-dengue potential are being studied; no anti-dengue drug is available so far.

show abstract