Serum levels of macrophage migration inhibitory factor and interleukin 17 in patients with nonsegmental vitiligo

Sorour, Osama S; Nassar, Eman Saad; Ahmed, Somaya M Eldin; Farid, Carmen

doi:10.4103/jewd.jewd_39_19

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…[ 149 ] In a randomized, rater‐blinded, comparative control experiment targeting humans, one study showed that the MN group had no side effects or pain and displayed significantly improved levels of hair growth compared to those in several control groups. [ 150–153 ]…”

Section: Recent Studies On Hair Regeneration Using Macromoleculesmentioning

confidence: 99%

Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment

Kang

Park

et al. 2023

Macromolecular Bioscience

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Macromolecules are large, complex molecules composed of smaller subunits known as monomers. The four primary categories of macromolecules found in living organisms are carbohydrates, lipids, proteins, and nucleic acids; they also encompass a broad range of natural and synthetic polymers. Recent studies have shown that biologically active macromolecules can help regenerate hair, providing a potential solution for current hair regeneration therapies. This review examines the latest developments in the use of macromolecules for the treatment of hair loss. The fundamental principles of hair follicle (HF) morphogenesis, hair shaft (HS) development, hair cycle regulation, and alopecia have been introduced. Microneedle (MN) and nanoparticle (NP) delivery systems are innovative treatments for hair loss. Additionally, the application of macromolecule‐based tissue‐engineered scaffolds for the in vitro and in vivo neogenesis of HFs is discussed. Furthermore, a new research direction is explored wherein artificial skin platforms are adopted as a promising screening method for hair loss treatment drugs. Through these multifaceted approaches, promising aspects of macromolecules for future hair loss treatments are identified.

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Section: Recent Studies On Hair Regeneration Using Macromoleculesmentioning

confidence: 99%

Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment

Kang

Park

et al. 2023

Macromolecular Bioscience

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“…In all patient groups, both were positively related to the extent and severity of the illness. Sorouret al [45]…”

Section: Serum Concentrations Of Mif In Vitiligomentioning

confidence: 99%

Macrophage Migration Inhibitory Factor in Vitiligo: Pathogenesis and Potential Therapeutic Aspects

Ibrahim

Nada

Ali

et al. 2021

AJBGMB

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Vitiligo is an acquired skin disorder that is characterized by a gradual loss of skin pigmentation when melanocytes, the skin's pigment-producing cellsis lost. Pathogenicmechanisms are not well understood. Genetic, abnormal biochemical pathways, autoimmune, melanocyte adhesion deficits and nervous system imbalances are among the pathogenic triggers. Vitiligo lesions have also been shown to have macrophage infiltration.Macrophagemigration inhibitory factor (MIF) is a lymphokine that concentrates macrophages at inflammatory sites and is involved in cell-mediated immunity.MIF enhances chemotaxis and macrophage infiltration and upregulates inflammatory responses by inducing the expression of proinflammatory mediators such as TNF-α, nitric oxide and prostaglandin E2.Therapyfor vitiligo includes corticosteroids, immunomodulatory agents, vitamin D nalogues, antioxidants, phototherapy, laser and surgical therapy.However, no single treatment for vitiligo produces consistently good results and treatment response is variable. Narrow-band ultraviolet (NB-UVB, 311–313nm) phototherapy is viewed as backbone of treatment. Systemic therapies such as systemic corticosteroids and methotrexate were previously used to treat vitiligo which was assumed to be auto-immune nature.Pathogenic mechanisms, role of MIF and various treatment guidelines are discussed in this review

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Serum levels of macrophage migration inhibitory factor and interleukin 17 in patients with nonsegmental vitiligo

Cited by 2 publications

References 2 publications

Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment

Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment

Macrophage Migration Inhibitory Factor in Vitiligo: Pathogenesis and Potential Therapeutic Aspects

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