Serum levels of leptin and IP-10 in preeclampsia compared to controls

Kalinderis, Michail; Papanikolaou, Athanasios; Kalinderi, Kallirhoe; Vyzantiadis, Timoleon‐Achilleas; Ioakimidou, Aliki; Tarlatzis, Basil C.

doi:10.1007/s00404-015-3659-4

Cited by 31 publications

(26 citation statements)

References 28 publications

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“…The increased risk of pre‐eclampsia and GDM with higher leptin levels are consistent with several other studies . In previous studies, leptin levels during pregnancy were observed to be higher among women with pre‐eclampsia compared with controls, though no previous studies assessed levels prior to pregnancy and subsequent pre‐eclampsia. Interestingly, women with gene polymorphisms on the leptin receptor gene (LEPR) were also more likely to develop severe pre‐eclampsia .…”

Section: Discussionsupporting

confidence: 90%

“…Given the strong positive association between high leptin levels and body mass index (BMI) and body fat mass, leptin may mediate the link between the increased risk of pregnancy complications in women with obesity. Leptin has been associated with pre‐eclampsia, gestational diabetes (GDM), higher rates of neonatal morbidity, mortality, and neonatal ICU admissions in the offspring . However, studies evaluating the relations between leptin and pregnancy outcomes have included only a small number of women and measured leptin levels during pregnancy, which cannot rule out reverse causality.…”

Section: Introductionmentioning

confidence: 99%

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Preconception leptin levels and pregnancy outcomes: A prospective cohort study

Plowden

Zarek

Rafique

et al. 2020

Obesity Science & Practice

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Objective: Obesity has become a major, worldwide public health issue and is associated with a greater risk of adverse pregnancy outcomes. Leptin, a hormone produced by adipocytes, is elevated in individuals with obesity and may mediate the association between obesity and pregnancy outcomes. Though leptin levels during pregnancy have been associated with pregnancy outcomes, less is understood regarding preconception levels. Therefore, the objective of this study was to evaluate associations between preconception leptin levels and adverse pregnancy outcomes. Methods:This was a prospective cohort study nested within a large randomized controlled trial conducted at four medical centres in the United States. A total of 1078 women completed the parent study; this analysis involved women who became pregnant during that study (n = 776). Patients were healthy women, ages 18 to 40, attempting to conceive, with 1 to 2 prior pregnancy losses. Participants were followed for less than or equal to 6 cycles while trying to conceive and throughout pregnancy if they conceived. Preconception leptin concentrations were measured in serum collected at baseline then categorized by tertiles (using the lowest as reference group). Weighted log-binomial regression estimated risk ratios (RR) and 95% confidence intervals (CIs) for pregnancy loss, preterm delivery (PTD), gestational diabetes (GDM), and hypertensive disorders in pregnancy, adjusting for age, waist-to-hip ratio (WHR), and body mass index (BMI). Results:The mean (SD) BMI in this cohort was 25.4 ± 6.0. GDM (RR 18.37; 95% CI,) and hypertensive disorders of pregnancy (RR 2.35; 95% CI, risks were higher among women in the high tertile after adjusting for age and WHR.The associated risk persisted when adjusting for BMI for GDM but was attenuated for hypertensive disorders in pregnancy. Leptin levels were not associated with risk of pregnancy loss or PTD.Clinical Trial Registration: The trial was registered on clinicaltrials.gov #NCT00467363.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Preconception leptin levels and pregnancy outcomes: A prospective cohort study

Plowden

Zarek

Rafique

et al. 2020

Obesity Science & Practice

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“…Although there are some promising predictive biomarkers, none of them has yet proven to be sensitive and specific enough for clinical practice [26][27][28]. If diagnosed early and managed properly, HELLP syndrome in most patients usually starts to improve within the first 24-48 h after delivery [29].…”

Section: Discussionmentioning

confidence: 98%

Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls

Karakuş

Akkar

Yıldız

et al. 2015

Arch Gynecol Obstet

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“…Involvement of leptin in pathogenesis of PE has been previously investigated. A study reported that, PE is considered an exaggerated inflammatory condition in which leptin inhibits the generation and proliferation of T-regulatory cells and induces the Th-17 cells responsible for activation of the inflammatory reaction (12). Leptin also, mediates the production of pro-inflammatory cytokines like TNF-α and IL-6 in PE inducing maternal vascular and renal pathology that provoke hypertension and proteinuria (25).…”

Section: Discussionmentioning

confidence: 99%

“…The ischemic placental hypoxia stimulates the release of different dysfunctional factors, particularly from the renal tissue eliciting maternal hypertension and proteinuria in PE. Severe oxidative stress (OS) and the release of various maternal and placental factors are the main players inducing endothelial dysfunction which is the crucial event in pathophysiology of PE (12). Addition of severe OS induced by PE to its already elevated level due to a high altitude (HA) residence could accentuate the release of these placental and maternal factors causing more severe maternal endothelial dysfunction that increases the prevalence of this condition in HA resident pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Impact of High Altitude on Maternal Serum Leptin Level and Its Correlation with Oxidative Stress and Endothelial Inflammatory Markers in Preeclamptic Women

Morsy

et al. 2018

Chin. J. Physiol.

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Involvement of leptin in the pathogensis of preeclampsia (PE) is still a controversy subject. Several researches reported the changes in serum leptin in high altitude (HA) residents. The aim of the present work was to investigate the impact of oxidative stress (OS) induced by HA residence on maternal serum leptin in PE and if there was a significant correlation between the serum leptin with either OS or endothelial inflammatory markers. One hundred fifty eight pregnant women were included in this study, divided into: low altitude normal pregnancies (NL), HA normal pregnancies (NH), low altitude preeclamptic (PL), and HA preeclamptic (PH) who presented to the obstetrics and gynecology outpatient clinic in both Muhayl (500 m over sea level) and Abha General Hospitals (all of them resident at Alsoda district with the average altitude 2700 m over sea level). Serum leptin, superoxide dismutase (SOD) activity, malondialdehyde (MDA), plasma nitrite/nitrate (NOx), serum tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), blood urea nitrogen (BUN) and creatinine were determined. Both NH and PL groups showed significant increases in leptin (P< 0.01), SOD (P < 0.01), MDA (P< 0.001), NOx (P < 0.001), TNF-α (P < 0.001) and IL-6 (P < 0.001) compared with the NL group without any significant changes between both groups. The PH group showed significant accentuation of the previously measured parameters (P< 0.001 for all) compared with all other groups (NL, NH and PL groups). We can conclude that the combination of PE and HA residence resulted in significantly elevated maternal serum leptin suggesting involvement of leptin in the pathogenesis of PE accentuated by HA residence.

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Serum levels of leptin and IP-10 in preeclampsia compared to controls

Abstract: The results of the present study support a significant role of leptin in PE; however, this association was independent from serum IP-10 levels, suggesting that there is no crucial interplay between these two proteins in PE.

Cited by 31 publications

References 28 publications

Preconception leptin levels and pregnancy outcomes: A prospective cohort study

Preconception leptin levels and pregnancy outcomes: A prospective cohort study

Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls

Impact of High Altitude on Maternal Serum Leptin Level and Its Correlation with Oxidative Stress and Endothelial Inflammatory Markers in Preeclamptic Women

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