Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia

Falkensammer, Juergen; Stojaković, Tatjana; Huber, Kurt; Hammerer-Lercher, Angelika; Gruber, I; Scharnagl, Hubert; Fraedrich, Gustav; Santner, Wolfram; Schocke, Michael; Greiner, Andreas

doi:10.1515/cclm.2007.087

Cited by 38 publications

(24 citation statements)

References 29 publications

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“…The levels of serum IMA were analyzed using the rapid and colorimetric method developed by Bar et al 14 The results were reported as absorbance unit (ABSU). The adjusted IMA levels were calculated with the formula suggested by Lippi et al 15 Albumin-adjusted IMA (AdJ-IMA) levels expressed as individual serum albumin concentration/median albumin concentration of the population x IMA value.…”

Section: Measurement Of Ischemia-modified Albuminmentioning

confidence: 99%

“…Serum IMA levels were found to be increased in non-myocardial ischemic conditions such as skeletal muscle ischemia, stroke, and pulmonary thromboembolism. 16,24 The cobalt-binding capacity of albumin reduces, because of oxidative free radicals during ischemia and this new chemically changed albumin can be measured with albumin cobalt binding test. High values of IMA are closely related to ischemia.…”

Section: Articlementioning

confidence: 99%

“…13 Ischemia-modified albumin (IMA) has emerged as a sensitive biomarker in the evaluation of tissue ischemia, and was used in many ischemic conditions such as myocardial ischemia, skeletal muscle ischemia, pulmonary embolism, and stroke. [13][14][15][16] To the best of our knowledge, there are no studies showing whether this increases after axillary dissections during mastectomy.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Electrocautery and Plasmablade on Ischemia and Seroma Formation after Modified Radical Mastectomy for Locally Advanced Breast Cancer

Alptekın

Yılmaz

Öztürk

et al. 2017

Surgical Techniques Development

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The aim of this study was to compare postoperative drainage volumes and IMA levels in patients who underwent modified radical mastectomy (MRM) with using PlasmaBlade (PB) or electrocautery (EC). A total of 36 patients who underwent MRM with PB or EC in our clinic between August 2012 to February 2013 were enrolled. Number of removed and positive lymph nodes, duration of drainage and total drainage volume was recorded. Seroma formation after drain removal and number of aspirations were also recorded. Serum ischemia modified albümine (IMA) levels were analysed before surgery, 1 hour and 24 hour after surgery. In total, 36 patients were treated with MRM in the study period. Of the 36 patients, 16 underwent MRM with PB, and 20 underwent MRM with EC. The patients demographics were similar in both groups. The mean drainage volume and seroma formation were significantly higher in the PB group when compared with EC group (P<0.05). Number of aspirations due to the seroma were also high in PB group. The total aspiration volume of seroma was not different in both groups. IMA levels 24 hours after surgery in the PB group was significantly higher than EC group. There was no statistical significance between the groups for IMA levels at 1 st hour. PB is a monopolar energy device and is associated with increased levels of ischemia. This situation resulted with an increased volume of total axillary drainage and elevated risk of seroma formation.

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Section: Measurement Of Ischemia-modified Albuminmentioning

confidence: 99%

Section: Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Electrocautery and Plasmablade on Ischemia and Seroma Formation after Modified Radical Mastectomy for Locally Advanced Breast Cancer

Alptekın

Yılmaz

Öztürk

et al. 2017

Surgical Techniques Development

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“…Serum levels of IMA increase in other diseases, such as acute stroke, pulmonary embolus, peripheral artery disease and end-stage renal disease [9,10,11,12,13]. In addition, various other conditions, such as exercise, acidosis, or dehydration, also contribute to elevation of IMA levels [14,15]. In contrast to the investigators supporting IMA as a prognostic factor for future cardiovascular events, several teams [16,17,18]reported that IMA was unable to predict serious cardiac outcomes in the short term in patients with potential acute coronary syndrome.…”

Section: Introductionmentioning

confidence: 99%

Ischemia-Modified Albumin: Is It a Reliable Diagnostic and Prognostic Marker for Myocardial Ischemia in Real Clinical Practice?

Kim

Hwang²,

Ko³

et al. 2010

Cardiology

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Objectives: We investigated whether ischemia-modified albumin (IMA), a novel biomarker of acute myocardial ischemia, is reliable for diagnosing ischemic chest pain and predicting future cardiac events in clinical practice. Methods: We enrolled 390 patients (age 61.7 ± 39.9 years) who arrived at the emergency department within 6 h of pain onset. We compared serum IMA levels of patients with ischemic chest pain (ICP) to those with nonischemic chest pain (NICP). Results: NICP was diagnosed in 162 patients and ICP in 205 patients. Median serum IMA levels did not differ between the NICP (99.0 U/ml; 95% confidence interval, 98.2–101.2 U/ml) and the ICP group (99.0 U/ml; 95% confidence interval, 99.4–102.6 U/ml; p = 0.320). During a 2-year follow-up, adverse cardiac events including cardiac death, myocardial infarction and recurrent angina occurred in 25 of 205 patients (12.2%) in the ICP group, but IMA was not predictive of cardiac events. Conclusions: IMA was neither able to discriminate acute chest pain due to myocardial ischemia from that of other origin nor to predict cardiac events. Therefore, use of serum IMA levels for triage of patients with acute chest pain does not seem effective in clinical practice.

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“…Most investigations involving IMA and physical activity have focused on the acute effects of exercise, [26][27][28][29] but only one study was found to investigate the chronic effects of exercise training (aerobic) in non-athletes 30 and no studies were found regarding RT and IMA levels. In this matter, three months of moderate-intensity walking unchanged IMA levels in type 2 diabetes mellitus patients, while its levels increased in the sedentary group.…”

Section: Discussionmentioning

confidence: 99%

Impact of Resistance Training on Quality of Life and Ischemia Modified Albumin Levels in Men with Cardiovascular Risk Factors

Farinha¹,

Martins²,

Benetti³

et al. 2014

Heart Res Open J

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There are limited data concerning the effects of Resistance Training (RT) on the components of Quality of Life (QOL) and Ischemia Modified Albumin (IMA) serum levels, even though QOL is an important characteristic related to the treatment success involving non communicable diseases. Studies regarding IMA and physical activity have focused only in the acute effects of exercise. Thereby, the purpose of this study is to investigate the effects of a moderate intensity RT on Health-related Quality of Life (HRQoL) and IMA levels in men with cardiovascular risk factors. Methods: Nineteen sedentary men (59 ± 8.63 years old) with metabolic syndrome (MS) components underwent a RT with sessions three times a week, comprising 12 exercises, during 12 weeks. The Short-Form 36 was administered to evaluate the domains of physical and mental components of HRQOL pre and post-intervention. Body composition and serum biochemical parameters were analyzed. Results: Volunteers had total body fat content and total muscle mass unchanged along the intervention. With regard to serum analysis, triglycerides and IMA levels remained unchanged with RT, while increased HDL levels (p < 0.001) and reduced ratio between total and HDL cholesterol (p = 0.006) were observed. Moreover, improvements in the HRQOL subscales of role-physical (p = 0.048), general health (p < 0.001), vitality (p < 0.001), social functioning (p = 0.044) and mental health (p = 0.006) were verified after the RT. Conclusions: It was concluded that a moderate RT is useful in providing benefits on quality of life in men with cardiovascular risk factors, despite the maintenance of IMA levels.KEYWORDS: Quality of Life; Middle aged; Strength training; Health, Metabolic Syndrome X; Ischemia-modified serum albumin. MAiN KEY FiNDiNgS-Resistance training provides improvements on physical and mental components of quality of life in men with cardiovascular risk factors; -Benefits on quality of life outcomes afforded by moderate resistance training are independent of changes in ischemia modified albumin levels and body composition adaptations.

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Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia

Cited by 38 publications

References 29 publications

Comparison of Electrocautery and Plasmablade on Ischemia and Seroma Formation after Modified Radical Mastectomy for Locally Advanced Breast Cancer

Comparison of Electrocautery and Plasmablade on Ischemia and Seroma Formation after Modified Radical Mastectomy for Locally Advanced Breast Cancer

Ischemia-Modified Albumin: Is It a Reliable Diagnostic and Prognostic Marker for Myocardial Ischemia in Real Clinical Practice?

Impact of Resistance Training on Quality of Life and Ischemia Modified Albumin Levels in Men with Cardiovascular Risk Factors

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