Serum levels of interleukin (IL)-27 in patients with ischemic heart disease

Jafarzadeh, Abdollah; Nemati, Maryam; Rezayati, Mohammad Taghi

doi:10.1016/j.cyto.2011.06.014

Cited by 52 publications

(57 citation statements)

References 25 publications

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“…IL-6, IL-21 and TGF-β induce diff erentiation of Th17 cells (Mangan et al, 2006), whereas IL-23 is required for expansion and pathogenicity in vivo (Aggarwal et al, 2003). Recent studies suggest that IL-17 plays a role in the pathogenesis of coronary disease (Jafarzadeh et al, 2009;Liang et al, 2009;Hashmi and Zeng, 2006). Indeed, patients developing acute coronary disease showed increased IL-17 serum levels and those who evolved into a MI attained still higher levels than patients with only unstable angina.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, patients developing acute coronary disease showed increased IL-17 serum levels and those who evolved into a MI attained still higher levels than patients with only unstable angina. Authors suggested that IL-17 levels could be used as a predictor of the inflammatory activity within coronary vessels and therefore as a risk factor for coronary incidents (Jafarzadeh et al, 2009). This idea was highlighted by a recent study that evidenced an atherogenic role of IL-17A in a disease model in IL-17A (-/-) mice (Chen et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, a role for Th17 cells has also been suggested in ischemic heart disease. Observations in patients with ACS revealed a signifi cant increase in peripheral Th17 cell numbers and Th17-related cytokines (Jafarzadeh et al, 2009;Liang et al, 2009;Hashmi and Zeng, 2006). In fact, a concurrent decrease in the number of anti-infl ammatory T regulatory (Treg) cells and Treg-related cytokines -(IL-10 and transforming growth factor (TGF-β1) in these patients indicates that a proinfl ammatory Th17/Treg imbalance could be a feature also of the ACS (Cheng et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

et al. 2012

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Th17 cells, a recently described subtype of CD4+ eff ector lymphocytes, have been linked to cell-mediated autoimmune and infl ammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defi ned. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. Only TGF-β mRNA remained elevated at week 4 post-MI. However, further analysis revealed that IL-17A mRNA and protein levels as well as IL-6 and IL-23 mRNA were indeed increased in the infarcted region, though not in the remote non infarcted region of the LV, except for IL-23 mRNA. The increased expression of IL-17A and Th17-related cytokines in the infarcted region of LV, suggests that this proinfl ammatory pathway might play a role in early stages of post MI cardiac remodelling.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

et al. 2012

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“…In other studies, elevated plasma or serum levels of IL-17 were also reported in patients with non stable angina or in patients with acute myocardial infarction [153,154]. It has been suggested that increased levels of IL-17 may be associated with ischemic heart disease [154].…”

Section: Interleukin-17 (Il-17)mentioning

confidence: 97%

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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“…TNFα closely relates to left ventricular dysfunction, remodeling, cardiac myocyte apoptosis, attenuation of β adrenergic responsiveness, and activation of inducible nitric oxide synthase 7 . On the other hand, increasing evidence is emphasizing the impact of novel cytokine interleukin-17A (IL-17) in the pathogenesis of CHF 8,9 . The neutralization of IL-17 reduces myocarditis severity 9 and has an essential role in the development of dilated cardiomyopathy 10 .…”

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confidence: 99%