Serum levels of interleukin‐8, tumor necrosis factor‐α and γ‐interferon in Egyptian psoriatic patients and correlation with disease severity

Hamid, Mahmoud F. Abdel; Aly, Dalia Gamal; Saad, Nevine E.; Emam, Hanaa; Ayoub, Dina F.

doi:10.1111/j.1346-8138.2010.01018.x

Cited by 32 publications

(24 citation statements)

References 14 publications

(31 reference statements)

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“…Although one of the limitations of the current study is the lack of data regarding plasma proinflammatory cytokine levels of the study subjects, the role of cytokines has been extensively studied in patients with psoriasis. Serum TNF-α and IFN-γ levels were significantly higher in patients with active psoriasis and these high serum levels were positively correlated with the clinical severity and activity of the disease 19 , 20 . The serum levels of these cytokines were reported to serve as a follow-up marker for monitoring disease severity 19 , 20 .…”

Section: Discussionmentioning

confidence: 94%

“…Serum TNF-α and IFN-γ levels were significantly higher in patients with active psoriasis and these high serum levels were positively correlated with the clinical severity and activity of the disease 19 , 20 . The serum levels of these cytokines were reported to serve as a follow-up marker for monitoring disease severity 19 , 20 . Overexpression of TNF-α has been demonstrated in the plasma and skin lesions of psoriatic patients 1 , 5 , 6 , 19 , 20 and anti-TNF-α therapy has gained popularity in recent years 1 , 6 .…”

Section: Discussionmentioning

confidence: 94%

“…The serum levels of these cytokines were reported to serve as a follow-up marker for monitoring disease severity 19 , 20 . Overexpression of TNF-α has been demonstrated in the plasma and skin lesions of psoriatic patients 1 , 5 , 6 , 19 , 20 and anti-TNF-α therapy has gained popularity in recent years 1 , 6 . TNF-α, an immunomediator and proinflammatory cytokine, is a potent neurotoxic substance that induces apoptotic cell death 21 - 25 .…”

Section: Discussionmentioning

confidence: 99%

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Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris

Demir¹,

Kalkan²,

Kurt³

et al. 2015

Clinics

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OBJECTIVES:Psoriasis is a hyperproliferative chronic inflammatory skin disease of unknown etiology and ocular structures and visual pathways can also be affected during the course of this disease. Subclinical optic neuritis has previously been observed in psoriatic patients in visual evoked potential studies. This trial was designed to evaluate retinal sensitivity in patients with psoriasis vulgaris.METHODS:A total of 40 eyes of 40 patients with chronic plaque-type psoriasis and 40 eyes of 40 age- and sex-matched control subjects were included in this study. The diagnosis of psoriasis was confirmed by skin biopsy. The severity was determined using the Psoriasis Area and Severity Index and the duration of the disease was recorded. After a full ophthalmological examination, including tests for color vision and pupil reactions, the visual field of each subject was assessed using both standard achromatic perimetry and short wavelength automated perimetry.RESULTS:The mean Psoriasis Area and Severity Index was 22.05±6.40′. There were no significant differences in the visual field parameters of subjects versus controls using either method. There were correlations between disease severity and the mean deviations in standard achromatic perimetry and short wavelength automated perimetry and between disease severity and the corrected pattern standard deviation and pattern standard deviation of short wavelength automated perimetry (r = -0.363, r = -0.399, r = 0.515 and r = 0.369, respectively).CONCLUSIONS:Retinal sensitivity appears to be affected by the severity of psoriasis vulgaris.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris

Demir¹,

Kalkan²,

Kurt³

et al. 2015

Clinics

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“…Our study detected no significant correlations between the PASI and the TNF- α serum levels. There are papers confirming no correlation between TNF- α and PASI [ 28 , 29 , 37 ], and others stating the opposite [ 32 , 34 ]. This controversy may be due to the heterogeneity of the inclusion criteria and study populations ( Table 5 ).…”

Section: Resultsmentioning

confidence: 99%

Serum Levels of TNF-α, IL-12/23p40, and IL-17 in Plaque Psoriasis and Their Correlation with Disease Severity

Kyriakou

Patsatsi

Vyzantiadis

et al. 2014

Journal of Immunology Research

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A case-control study was performed to assess the serum levels of TNF-α, IL-12/23p40, and IL-17 in patients with plaque psoriasis, compare them with healthy controls, and correlate them with disease severity, as represented by Psoriasis Area Severity Index (PASI). 32 consecutively selected, untreated patients with active, chronic plaque psoriasis were recruited and compared to 32 age- and sex-matched healthy controls. Serum cytokine levels were determined by solid phase sandwich enzyme linked immunosorbent assay (R&D Systems Europe, Ltd.). The mean serum levels of TNF-α were significantly higher in psoriatic patients compared to those of controls (Mann-Whitney U test; P = 0.000). However, the median serum levels of neither IL-12/23p40 nor IL-17 differ significantly between the 2 groups (Mann-Whitney U test; P = 0.968 and P = 0.311, resp.). No significant correlations were found between PASI and any of the cytokine serum levels (Spearman's rank test; P > 0.05). Despite the well-evidenced therapeutic efficacy of biologic agents targeting TNF-α, IL-12/23p40, and IL-17, serum levels of TNF-α, IL-12/23p40, and IL-17 do not seem to correlate with the severity of psoriatic skin disease in untreated patients, as represented by PASI. Further investigation may add more data on the pathogenetic cascade of psoriasis.

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“…Psoriasis is associated with a systemic immunodysregulation characterized by high expression of pro-infiammatory cytokines, but T-cell hypo-responsiveness, including decreased IFN-y production (12,(14)(15)(16)(17)(18). Among them, TNF plays an early and key role in the pro-infiarnmatory cascade.…”

Section: Discussionmentioning

confidence: 99%

Infliximab Does Not Lead to Reduction in the Interferon-gamma and Lymphoproliferative Responses of Patients with Moderate to Severe Psoriasis

Ortigosa¹,

Silva²,

Duarte³

et al. 2014

Acta Derm Venerol

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Treatment of patients with immune-mediated inflammatory diseases with anti-tumour necrosis factor (anti-TNF) agents increases the risk of tuberculosis reactivation, suggesting that it may affect their cellular immune responses. We evaluated cellular immune responses of 12 severe psoriasis patients before and during infliximab treatment. Peripheral blood mononuclear cells were stimulated with phytohaemagglutinin, the superantigen enterotoxin B (SEB), a cytomegalovirus lysate (CMV), and Mycobacterium tuberculosis (Mtb) antigens. The lymphocyte proliferative and IFN-γ responses were evaluated. Treatment with infliximab did not lead to reduction in the IFN-γ and lymphoproliferative responses: it rather increased the overnight release of IFN-γ in phytohaemagglutinin and SEB stimulated cultures. This effect was most noted at the peak of the anti-TNF clinical effect and less prominent at its nadir. Immunoreactivity to CMV was also either unaffected or slightly increased by the anti-TNF. Of note, the IFN-γ and proliferative responses to Mtb by the two tuberculin skin test-reactors were also increased at the peak of infliximab, declining at its nadir. The deleterious consequences of TNF blockade in severe psoriasis patients undergoing infliximab treatment are apparently attenuated by the abbreviation of the immunosuppressive effect of TNF overexpression.

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Serum levels of interleukin‐8, tumor necrosis factor‐α and γ‐interferon in Egyptian psoriatic patients and correlation with disease severity

Cited by 32 publications

References 14 publications

Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris

Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris

Serum Levels of TNF-α, IL-12/23p40, and IL-17 in Plaque Psoriasis and Their Correlation with Disease Severity

Infliximab Does Not Lead to Reduction in the Interferon-gamma and Lymphoproliferative Responses of Patients with Moderate to Severe Psoriasis

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