Serum Levels of Interleukin 6, Interleukin 8, and C-Reactive Protein After Human Allogeneic Bone Marrow Transplantation

Schwaighofer, Hubert; Herold, Manfred; Schwarz, Tobias; Nordberg, J; Ceska, M.; C, Prior; Nachbaur, David; Weyrer, W; Brankova, J.; Eibl, Brigitte; Tilg, Herbert; Bowden, RA; Niederwieser, D

doi:10.1097/00007890-199408270-00007

Cited by 46 publications

(38 citation statements)

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“…A detailed comparison of cytokine serum concentrations including pro-or anti-inflammatory effects showed a very high variability that hindered further analysis. 5,6,15 Most of the cytokines are produced by specific cell types in response to specific stimuli. In contrast, IL-6 is produced by almost all cells, including hepatocytes, in response to any type of stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…These cytokines have been found to be involved in many adverse conditions initiated by HSCT. [2][3][4][5][6] IL-10 is a Th2 cytokine that inhibits cytokine production by Th1 cells, and IL-10 is reported to block the production of the monokines (IL-1, IL-6 and TNF-␣) in response to lipopolysaccharide or other stimuli. 7,8 High spontaneous IL-10 production in transplant recipients is associated with fewer transplantrelated complications, and is believed to have a major role in maintaining immunobalance in the allogeneic HSCT setting.…”

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confidence: 99%

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The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation

Min

Lee

Min

et al. 2001

Bone Marrow Transplant

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Summary:Pro-inflammatory (IL-6, TNF␣ and IL-8) and antiinflammatory (IL-10) cytokines were determined in weekly samples from 52 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). IL-6 increased immediately after transplant peaking at week +3, but IL-8 concentrations were elevated only during week +1. After a slight decrease in week +1, TNF-␣ significantly increased from week +2 and peaked at week +3, whereas, IL-10 values started to rise in week +2 and peaked during week +4. IL-6 and TNF-␣ were positively correlated from week +2 to week +4, and IL-6 levels at week +1 were related with fever and severe stomatitis. Serum levels of IL-6 at week +1 and IL-10 at week +4 were significantly higher in patients with early transplant-related complications, such as fever, severe stomatitis or acute GVHD у overall grade II than in those without the complications. We conclude that a high serum IL-6 level at week +1 may be an early predictor of transplant-related complications and that it seems to trigger pro-and anti-inflammatory cytokine release. Kinetic patterns of IL-6 and IL-10 were more exaggerated in those with complications after HSCT. Bone Marrow Transplantation (2001) 28, 935-940.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation

Min

Lee

Min

et al. 2001

Bone Marrow Transplant

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“…Antigenactivated T cells are not only involved in GvHD and graft rejection, but also leukemia control and protection against infectious agents (Min et al 2006). On the other hand, some authors report the lack of association between CRP levels and exclusive GvHD (Pihusch et al 2006;Saarinen et al 1987;Schwaighofer et al 1994). Schwaighofer et al (1994) observed increased CRP levels after bone marrow transplantation (BMT) during severe infections or FUO, but not in the case of aGvHD grade III/IV.…”

Section: Graft-versus-host Diseasementioning

confidence: 99%

“…On the other hand, some authors report the lack of association between CRP levels and exclusive GvHD (Pihusch et al 2006;Saarinen et al 1987;Schwaighofer et al 1994). Schwaighofer et al (1994) observed increased CRP levels after bone marrow transplantation (BMT) during severe infections or FUO, but not in the case of aGvHD grade III/IV. They measured CRP every second day from day -6 to day ?86 in patients undergoing BMT.…”

Section: Graft-versus-host Diseasementioning

confidence: 99%

“…A further increase was associated with infectious complications or FUO, but not with aGvHD grade III or IV. Since no increase of CRP was observed during GvHD, they hypothesized that CRP is not involved in the induction of GvHD and thus suggested that it might be used in the diagnosis of infectious complications after allogeneic HSCT (Schwaighofer et al 1994). Pihusch et al (2006) analyzed levels of CRP, PCT and IL-6 prior to conditioning and weekly until 8 weeks after HSCT.…”

Section: Graft-versus-host Diseasementioning

confidence: 99%

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Inflammatory Markers in Patients after Hematopoietic Stem Cell Transplantation

Sjøqvist

Snarski

2013

Arch. Immunol. Ther. Exp.

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Infections are one of the most common complications after hematopoietic stem cell transplantation (HSCT). Diagnosis is established by analysis of clinical symptoms and results of diagnostic tests such as biochemical panels, microbiological cultures, and visual diagnostics. As the microbiological cultures yield positive results in only some patients and visual diagnostics might miss the infectious source, the diagnosis and proper treatment often depends on clinical assessment supported by laboratory test results. The most commonly used makers of inflammation include C-reactive protein and procalcitonin. However, these tests have serious limitations when used in patients after HSCT. The drugs used in conditioning, neutropenia, and graft-versus-host disease might influence the results of the tests and misguide the physician. In this review, we summarize the current knowledge on profiles of expression of basic markers of inflammation used in clinical practice in patients after HSCT.

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Literatur

Deng¹

1997

Zytokinregulation Bei Chronischer Herzinsuffizienz, Extrakorporaler Zirkulation Und Herztransplantation

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Serum Levels of Interleukin 6, Interleukin 8, and C-Reactive Protein After Human Allogeneic Bone Marrow Transplantation

Cited by 46 publications

References 0 publications

The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation

The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation

Inflammatory Markers in Patients after Hematopoietic Stem Cell Transplantation

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