Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs), -1, -2, -3, in oral cancer

Brady, Garrett; O’Regan, Esther; Miller, I.D.; Ogungbowale, A.; Kapas, S.; Crean, St John

doi:10.1016/j.ijom.2006.09.009

Cited by 22 publications

(40 citation statements)

References 16 publications

(16 reference statements)

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“…On the other hand, down-regulation of IGFBP-3 has been found in patients with tongue carcinoma and significantly associated with shorter disease-specific survival [70]. In addition, patients with head and neck cancer have been shown to have increased plasma levels of IGFBP-1 and IGFBP-2 in contrast to the levels of IGF-1 and IGFBP-3, which were found to be low [71]. However, no significant association was demonstrated between these findings and the tumor size or nodal status.…”

Section: Other Factors Implicated In Lymphangiogenesismentioning

confidence: 99%

Molecular pathways of lymphangiogenesis and lymph node metastasis in head and neck cancer

Karatzanis

Koudounarakis

Papadakis

et al. 2011

Eur Arch Otorhinolaryngol

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Metastasis to regional lymph nodes constitutes the main route toward progression and dissemination of head and neck carcinoma; at the same time it is the most significant adverse prognostic indicator for this disease. In recent years, significant focus has been given on the molecular mechanisms behind lymph node metastasis of head and neck cancer. The aim of this study is to assess the role of growth factor expression and function in association with lymph node metastasis and overall prognosis of head and neck cancer. Current literature, searching for experimental data regarding the molecular pathways of lymph node dissemination of head and neck cancer, is reviewed giving special emphasis on the expression and prognostic significance of specific growth factors. Members of the vascular endothelial growth factor (VEGF), mostly VEGF-C and VEGF-D, with their action through the receptors VEGFR-3 and VEGFR-2, constitute the most extensively studied growth factors associated with lymphangiogenesis so far. High expression of these as well as other molecules, including angiopoietins, insulin-like growth factor, and fibroblast growth factor, has been associated with lymph node metastasis and poor prognosis in head and neck squamous cell carcinoma. Numerous growth factors seem to play an important role regarding the lymph node metastatic potential of head and neck cancer. Further research is necessary in order to further clarify the molecular pathways and introduce novel therapeutic options.

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Section: Other Factors Implicated In Lymphangiogenesismentioning

confidence: 99%

Molecular pathways of lymphangiogenesis and lymph node metastasis in head and neck cancer

Karatzanis

Koudounarakis

Papadakis

et al. 2011

Eur Arch Otorhinolaryngol

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“…On the contrary, Brady et al showed that circulating levels of both IGF1 and IGFBP3 protein are decreased in head and neck cancer patients (Brady et al, 2007).…”

Section: Introductionmentioning

confidence: 96%

“…Only a few studies have investigated head and neck cancer and IGF-1 association (Doyle et al, 2012;Brady et al, 2007) It has been reported that patients with head and neck cancer that developed second primary tumors have high levels of IGF-1 and low levels of IGFBP-3, so these markers (IGF1/IGFBP-3) represent positive risk factors (Wu et al, 2004). On the contrary, Brady et al showed that circulating levels of both IGF1 and IGFBP3 protein are decreased in head and neck cancer patients (Brady et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Usefulness of IGF-1 serum levels as diagnostic marker of nasopharyngeal carcinoma

et al. 2016

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“…However, serum levels of IGFBP-1 and IGFBP-2 were elevated. 41 Papadimitrakopoulou et al showed that downregulation of IGFBP-3 is a highly significant predictor of poor outcome for patients with tongue cancer. 42 Previous studies have described the expression of various proteins of the IGF system in normal oral and epithelial tumour cell lines.…”

Section: Discussionmentioning

confidence: 99%

Insulin-like growth factor-1 receptor expression in oral squamous cell carcinoma

Joseph

Sundaram²

2011

J Clin Exp Invest

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ÖZETAmaç: İnsülin benzeri büyüme faktörü-1 reseptörü (IGF-1R)'ün kanser gelişiminde, proliferasyon ve sağkalımda önemli rolleri vardır. IGF-1R aşırı salınımı sıklıkla çeşitli tümörlerde gözlenir ve çoğunlukla agresif fenotiple birliktedir. Bu çalışmanın amacı normal ağız içi mukozası, fibroepitelyal polipler, displastik ağız mukozası ve iyi diferensiye yassı epitel hücreli karsinom'da IGF-1R ekspresyonunu araştırmaktır.Gereç ve yöntem: IGF-1R ekspresyonunu normal ağız içi mukozası, fibroepitelyal polipler, displastik ağız mukozası ve iyi diferensiye yassı epitel hücreli karsinom'da araştırmak için üç basamaklı bir streptavidin peroksidaz immunohistokimyasal yöntem kullanıldı. Bulgular:Yassı epitel hücreli karsinomların tümü (15 hasta) IGF-1R için yoğun immunoreaktivite gösterdi. Orta düzeyde immun reaktivite "prickle" hücre lezyonu tabakasıyla birlikte displastik ağız içi lezyonlarda (12 hastadan 12'sinde) görüldü. Selim lezyonlarda (14 hasta) boyama dağılımı daha zayıftı ve yassı epitel hücreli karsinom ve displastik lezyonlarla kıyaslandığında, normal ağız mukozasında (10 örnek) görülene benzer şekilde idi.Sonuç: Bulgularımız, ağız içi yassı epitel hücreli karsinom ve oral kanser gelişiminde önemli rolleri olabileceği-ni telkin eder tarzda, IGF-1R'nin ekspresyonunun arttığını göstermektedir.Anahtar kelimeler: Büyüme faktörleri, insülin-benzer büyüme reseptörü, epitelyal displazi, ağız içi yassı epitel hücreli karsinom, immunohistokimya ABSTRACT Objectives: The Insulin-like growth factor-I receptor (IGF-1R) plays critical roles in cancer development, proliferation, motility and survival. IGF-1R over expression is frequently found in various tumours and is often associated with an aggressive phenotype. Hence, the aim of the present study was to examine the expression of IGF-1R in normal oral mucosa, fibroepithelial polyps, dysplastic oral mucosa and well-differentiated squamous cell carcinomas. Materials and methods:A 3-layered streptavidin peroxidase immunohistochemical method was used to detect the expression of IGF-1R in normal oral mucosa, fibroepithelial polyps, dysplastic oral mucosa and well-differentiated squamous cell carcinomas.Results: All squamous cell carcinomas (15 out of 15 patients) showed intense immunoreactivity for IGF-1R. Moderate immunoreactivity was seen in dysplastic oral lesions (12 out of 12 lesions) with positive staining in the prickle cell layer. The staining distribution in the benign lesions (14 out of 14 lesions) was weaker and similar to that seen in normal oral mucosa (10 out of 10 samples) when compared to squamous cell carcinomas and dysplastic lesions.Conclusions: Our results demonstrate increased IGF-1 receptor expression in oral squamous cell carcinomas which suggests that IGF-1 may have an important role in the development of oral cancer. J Clin Exp Invest 2011; 2 (4): 354-361

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Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs), -1, -2, -3, in oral cancer

Cited by 22 publications

References 16 publications

Molecular pathways of lymphangiogenesis and lymph node metastasis in head and neck cancer

Molecular pathways of lymphangiogenesis and lymph node metastasis in head and neck cancer

Usefulness of IGF-1 serum levels as diagnostic marker of nasopharyngeal carcinoma

Insulin-like growth factor-1 receptor expression in oral squamous cell carcinoma

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