Serum levels of inflammatory cytokines in patients with idiopathic carpal tunnel syndrome

Karimi, Narges; Abediankenari, Saeid; Darvari, Fateme

doi:10.1080/00207454.2020.1737050

Cited by 10 publications

(14 citation statements)

References 26 publications

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“…In the more advanced stages, weakness and atrophy of the muscles of the thenar developed that in sequence causes the inability to accomplish activities (Stevens et al, 1992). The syndrome is diagnosed according to clinical symptoms, physical examination, and electrodiagnostic tests (Karimi et al, 2021;Razavi et al, 2021). There are several risk factors involved in causing this syndrome that comprises age, obesity, Diabetic Mellitus, rheumatoid arthritis, smoking, pregnancy, hypothyroidism, congenital anomalies and wrist injury (Karimi et al, 2017;Moghtaderi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Carpal Tunnel Syndrome in Female Patients With Hypothyroidism

Karimi

Akha

Rezaiefard

2024

BCN

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Introduction: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. There are several factors that influence the severity of CTS. The purpose of this study was to explore the severity of CTS in hypothyroid patients. Methods: This cross-sectional study was conducted in the university clinic. Seventy-six participants with a clinically and electrophysiological confirmed diagnosis of CTS were included in the study. The demographic data and severity of CTS were analyzed based on the presence (n=38) or the absence (n=38) of primary hypothyroid disease. Thirty-eight hypothyroid patients who were being treated were included in this study. For assessment of the severity of CTS, the Boston questionnaire (BCTQ) and electrodiagnostic tests were used. For data analysis, an independent sample t-test and Chi-squared tests were carried out. P-value<0.05 was considered significant. Results: The mean age of hypothyroid and non-hypothyroid CTS patients was 46.21±7.22 and 44.24±8.02, respectively. BMI was higher than 30kg/m2 in both two groups. There was no significant difference in the respect of demographic data among the two groups. The mean score of symptom severity in hypothyroid and non-hypothyroid-CTS patients were 30.37±10.84 and 35.89±7.19, and also functional status was 21.71± 9.04 and 25.92± 6.62, respectively. There was a significant difference between the two groups, in terms of symptom severity scale (p=0.017, CI95%:31.14-35.48) and functional status scale (p=0.023, CI95%:21.95-25.67). In terms of electrophysiological findings, there was no statistically significant difference between these two groups. Conclusion: The results of this study indicated that, contrary to expectation, the severity of CTS be higher in non-hypothyroid patients than in hypothyroid patients.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Carpal Tunnel Syndrome in Female Patients With Hypothyroidism

Karimi

Akha

Rezaiefard

2024

BCN

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“…However, the limited access to human neural tissue means that the clinical detection of inflammation mostly relies on indirect measures, such as the presence of systemic inflammatory markers in the blood. Most studies report changes in blood inflammatory markers in patients with neuropathic pain, however the limited number of cytokines studied (e.g., TNF, IL-6, IL1b, IL-4, IL-10) prevents a comprehensive overview and discovery of contributions of less studied cytokines in most studies [ 9 , 34 , 36 , 64 , 77 ].…”

Section: Introductionmentioning

confidence: 99%

“…CTS therefore represents an ideal model system that allows the prospective evaluation of inflammation from the active stage of nerve injury (pre-surgery) to recovery (post-surgery). There is growing evidence for a role of blood inflammatory mediators in the active stage of CTS [ 49 , 69 ], although conflicting results have also been reported [ 26 , 36 , 69 ]. The most comprehensive cross-sectional study to date suggested that serum concentrations of CCL5, VEGF, CXCL8 and CXCL10 as well as the number of central and effector memory T-cell populations were significantly increased in patients compared to healthy controls, confirming the presence of systemic inflammation in CTS [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory markers in neuropathic pain, nerve injury, and recovery

Sandy-Hindmarch

Bennett²,

Wiberg³

et al. 2021

Pain

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The role that inflammation plays in human nerve injury and neuropathic pain is incompletely understood. Previous studies highlight the role of inflammation in the generation and maintenance of neuropathic pain, but the emerging evidence from the preclinical literature for its role in the resolution of neuropathic pain remains to be explored in humans. Here, we use carpal tunnel syndrome (CTS) as a human model system of nerve injury and neuropathic pain to determine changes in serum cytokine protein levels and gene expression levels before (active stage of disease) and after carpal tunnel decompression surgery (recovery). Fifty-five patients with CTS were studied, and 21 healthy age-matched and gender-matched participants served as controls. In the active stage of the disease (CTS before surgery vs healthy controls), PTGES2 mRNA was decreased in patients (adjusted P 5 0.013), while transforming growth factor-b and C-C motif chemokine ligand 5 protein levels were increased (adjusted P 5 0.016 and P 5 0.047, respectively). In the resolution phase (CTS before surgery vs after surgery), IL-9 mRNA was increased after surgery (adjusted P 5 0.014) and expression of IL-6 mRNA and IL-4 protein levels were increased before surgery (adjusted P 5 0.034 and P 5 0.002, respectively). IL-9 mRNA expression negatively correlated with several (neuropathic) pain scores. By contrast, protein levels of IL-4 positively correlated with pain scores. In conclusion, we demonstrate specific dysregulation of systemic cytokine expression in both the active and resolution phases of nerve injury and neuropathic pain. IL-9 represents an interesting candidate associated with resolution of nerve injury and neuropathic pain.

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“…Women are also 10 times more prone to this disease than men [ 5 , 6 ]. Although the etiology of CTS is unknown, there are a number of risk factors, including diabetes mellitus, thyroid disease, wrist fracture, rheumatoid arthritis, amyloidosis, acromegaly, and also age and female gender [ 7 , 8 ]. Previous studies have indicated a relationship between high body mass index (BMI) and CTS.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have indicated a relationship between high body mass index (BMI) and CTS. Evidence also suggests that BMI plays a crucial role in the development of CTS [ 7 , 9 - 11 ]. According to some studies, BMI > 30 kg/m 2 augments fat deposition in the carpal canal and causes hydrostatic pressure over the median nerve within the carpal tunnel in the wrist [ 11 - 13 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship of serum lipid profiles and obesity with the severity of carpal tunnel syndrome

2021

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Introduction Carpal tunnel syndrome (CTS) is a prominent compressive neuropathy. There are a number of risk factors for creating CTS but the effect of these factors on the severity of CTS is unclear. In this study, we aimed to assess the correlation of serum lipid profile and obesity with the severity of CTS. Methods this cross-sectional study was conducted on 118 patients with idiopathic CTS. Blood samples were obtained for determining the serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) after 12 hours of overnight fasting. The participants were then divided into two groups of normal and abnormal serum lipids. Body mass index ≥ 30 kg/m 2 was considered as obesity. The severity of CTS was determined based on the electrophysiological results and Boston CTS Questionnaire (BCTSQ) that evaluates symptoms severity (SSS) and functional status (FSS) of patients. Results out of 118 participants, 108 patients performed lipid profile test that 41.17%, 50.42%, 25.21%, and 20.16% of them had TC ≥ 200, TG ≥ 150, LDL-C ≥ 130, and HDL-C < 60 milligrams per deciliter (mg/dl), respectively. The mean scores of SSS in patients with dyslipidemia including the high level of TC, TG, LDL-C, and low level of LDL-C were 34.59±7.86, 34.05±8.73, 34.93±8.21, and 33.48±7.56, respectively. There was no significant association between lipid profile and the symptom severity scale of CTS (p-value > 0.05). The mean BMI of participants was 31.35±5.35 kg/m 2 , and 58.5% of them had a BMI ≥ 30 kg/m 2 . The mean score of SSS and FSS was 33.18±8.24 and 24.43±7.12 in obese patients (BMI ≥ 30 kg/m 2 ), and was 34.06±7.85 and 23.06±7.67 in patients with BMI < 30 kg/m 2 . We found no significant association between obesity with the SSS and FSS (p-value = 0.53 and 0.32, respectively). In terms of the relationship between electrophysiological grading with obesity, 44 (63.8%) of patients with BMI ≥ 30 kg/m 2 and 22 (45.8%) patients with BMI < 30 kg/m 2 had severe to extreme severe CTS. There was no significant association between obesity and the severity of CTS (p-value = 0.054). Conclusion the results of this study did not demonstrate an association between serum lipid profile and obesity with the severity of carpal tunnel syndrome. The findings of this study may not be extrapolated to other populations. Further studies with more samples are needed to investigate this association.

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Serum levels of inflammatory cytokines in patients with idiopathic carpal tunnel syndrome

Cited by 10 publications

References 26 publications

Assessment of the Carpal Tunnel Syndrome in Female Patients With Hypothyroidism

Assessment of the Carpal Tunnel Syndrome in Female Patients With Hypothyroidism

Systemic inflammatory markers in neuropathic pain, nerve injury, and recovery

The relationship of serum lipid profiles and obesity with the severity of carpal tunnel syndrome

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