Serum Levels of Human Chorionic Somatomammotropin (Hcs) in Normal and Abnormal Pregnancies

Abstract

Serum levels of human placental chorionic somatomammotropin (HCS) were determined by radioimmunoassay (immunosorbent) in 800 pregnancies, normal as well as pathological. The normal group comprised 200 pregnant women (254 estimations). Correlation has been found to exist between the placental weight and the HCS levels as determined in the last few weeks before onset of labour.

Chorionic somatomammotrophin as index of fetal growth.

“…In this study MathCS bears a closer relation to PlachCS than to placental weight. Stronger correlations between MathCS and placental weight have been found when maternal blood is sampled before the onset of labour (Saxena et al, 1969;Seppala and Ruoslahti, 1970;Genazzani et al, 1971;Lebech and Borggaard, 1974), in contrast to the inconsistent relations seen in this study and in those of Spellacy et al (1966) and Samaan et al (1971) after the onset of labour. A more impressive MathCS-PlachCS relation may also exist if MathCS is sampled before labour but this remains to be explored.…”

Human placental lactogen (hPL) deficiency in a normal pregnancy

“…It is generally accepted that pregnancies with very low hPL levels are associated with maternal vascular problems, fetal delay of growth, and also with increased perinatal morbidity and mortality (Spellacy et al, 1975;Lebech and Borggaard, 1974;Moshirpur et al, 1981). Recently pregnancies have been described where very low levels or practically complete deficiency of hPL are associated with a normal gestation and the birth of normal babies, mostly male (Bock, Gaede and Trolle, 1976;Bradford and Hargreaves, 1978;Gaede, Trolle and Pedersen, 1978;Nielsen, Pedersen and Kampmann, 1979;Moshirpur et al, 1981;Di Renzo, Anceschi and Volpe, 1982); at least one normal female baby has also been delivered (Borody and Carlton, 1981).…”

Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives

“…In a group of term newborns (40th week), those born via vaginal delivery had significantly lower levels of PL in both the umbilical vein and umbilical artery compared with those born through cesarean section [49]. PL blood concentrations in multiple pregnancies tend to rise compared with single pregnancies [50].…”

“…The summary of clinical conditions associated with elevated and decreased placental lactogen blood levels[49][50][51]61,[65][66][67][86][87][88][89][90][91]94,99]. Created with BioRender.…”