Serum levels of high-sensitivity C-reactive protein in acute ischemic stroke and its subtypes: a prospective case-control study

Rana, Davinder Singh; Anand, Ish; Batra, Anuradha; Sethi, Prahlad K.; Bhargava, Seema

doi:10.4103/2542-3932.245216

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…The most common addiction in patients enrolled in our study was tobacco (chewing and smoking) with a prevalence of 29.33%. This is corroborated by findings in studies conducted by Davinder Singh Rana et al (14) and Jaydip Rai Chaudhuri et al (12) The average hsCRP level in the study population in the current study was 45.1238.07 mg/L. This shows that hsCRP levels are increased in case of stroke.…”

Section: Discussionsupporting

confidence: 92%

“…This suggests that higher hsCRP levels are associated with severe neurological deficit and thus worse outcome. Similar findings were obtained in the study by Pinky Talreja Mishra, (11) Jayachandra et al, (15) Ritesh Lal et al (18) and Davinder Singh Rana et al, (14) In the study by Ritesh Lal et al, (18) stroke patients were classified on the basis of Scandinavian Stroke Scale into minor, moderate and severe stroke. Patients with minor stroke had lower hsCRP values as compared to patients with severe stroke.…”

Section: Discussionsupporting

confidence: 79%

“…Male sex is also considered as a fixed risk factor for stroke. (10) Similar results were obtained in the studies conducted by Sujit Kumar et al, (13) Davinder Singh Rana et al (14) and Jayachandra et al (15) which had male preponderance. The most common comorbidity in the current study was hypertension (68%) followed by diabetes mellitus (22%).…”

Section: Discussionsupporting

confidence: 78%

“…Age is generally considered as a non-modifiable or fixed risk factor for stroke. (10) Similar results were obtained in studies conducted by Pinky Talreja Mishra et al, (11) Jaydip Ray Chaudhuri et al, (12) Sujit Kumar et al, (13) Davinder Rana et al, (14) Jayachandra et al, (15) the Mumbai Stroke Registry (16) and Yoshiyuki Wakugawa in the Hisayama Study. (17) In the current study there was male preponderance with 70.66% cases being male and 29.33% cases being female.…”

Section: Discussionsupporting

confidence: 73%

“…Patients with minor stroke had lower hsCRP values as compared to patients with severe stroke. In the study by Davinder Singh Rana et al, (14) hsCRP levels were correlated with acute ischemic stroke. Patients were classified as per NIHSS stroke scale into mild, moderate and severe grades.…”

Section: Discussionmentioning

confidence: 95%

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High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

Bhaisare¹,

Jog²,

Rao³

et al. 2020

jemds

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BACKGROUNDStroke is the leading cause of death worldwide and one of the main causes of long term disability. According to WHO, 15 million suffer from stroke each year. Studies have shown that levels of hsCRP measured shortly after stroke predicted complimentary aspects of prognosis. There is possibility that elevated hsCRP levels has direct relation to extent of cerebral tissue injury. We wanted to measure the levels of hsCRP in acute cerebrovascular accident. To correlate the level of hsCRP with severity of stroke and outcome. METHODSStudy was conducted in patients admitted in medical ward and medical ICU in tertiary care hospital (Grant Government Medical College and Sir JJ Group of Hospitals). It was a cross sectional study. A total of 150 patients who presented with stroke and fulfilled inclusion and exclusion criteria were enrolled in the study. In all patients hsCRP levels were measured within 48 hours of admission. Data was collected prospectively in a Microsoft Excel database. Statistical analysis was done using non-parametric ANOVA (Kruskal Wallis test) and Mann Whitney test. RESULTSMean age of patients was 59  12 years. hsCRP levels were raised in stroke patients. Also values were found to be more in haemorrhagic stroke (value) than in ischemic stroke (value) and the difference was found to be significant. Significant correlation was also found between hsCRP levels and GCS with lower GCS scores associated with higher hsCRP levels in both types of stroke. Mean hsCRP level in survivors was 21.83  23.17 mg/L and in non survivors was 82.07  25.83 mg/L and the difference was statistically significant (p <0.0001) CONCLUSIONSWe concluded that hsCRP level is increased in cases of stroke (both ischemic and haemorrhagic) suggesting an inflammatory response in acute stroke. Increased levels of hsCRP correlated with severity of neurological deficit and worse outcome.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 95%

See 3 more Smart Citations

High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

Bhaisare¹,

Jog²,

Rao³

et al. 2020

jemds

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Point-of-care optical biosensor platforms for stroke diagnostics with blood-based biomarkers

Harpaz¹

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Blood-Based Biomarkers Are Associated with Different Ischemic Stroke Mechanisms and Enable Rapid Classification between Cardioembolic and Atherosclerosis Etiologies

et al. 2020

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Stroke is a top leading cause of death, which occurs due to interference in the blood flow of the brain. Ischemic stroke (blockage) accounts for most cases (87%) and is further subtyped into cardioembolic, atherosclerosis, lacunar, other causes, and cryptogenic strokes. The main value of subtyping ischemic stroke patients is for a better therapeutic decision-making process. The current classification methods are complex and time-consuming (hours to days). Specific blood-based biomarker measurements have promising potential to improve ischemic stroke mechanism classification. Over the past decades, the hypothesis that different blood-based biomarkers are associated with different ischemic stroke mechanisms is increasingly investigated. This review presents the recent studies that investigated blood-based biomarker characteristics differentiation between ischemic stroke mechanisms. Different blood-based biomarkers are specifically discussed (b-type natriuretic peptide, d-dimer, c-reactive protein, tumor necrosis factor-α, interleukin-6, interleukin-1β, neutrophil–lymphocyte ratio, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein and apolipoprotein A), as well as the different cut-off values that may be useful in specific classifications for cardioembolic and atherosclerosis etiologies. Lastly, the structure of a point-of-care biosensor device is presented, as a measuring tool on-site. The information presented in this review will hopefully contribute to the major efforts to improve the care for stroke patients.

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Serum levels of high-sensitivity C-reactive protein in acute ischemic stroke and its subtypes: a prospective case-control study

Cited by 8 publications

References 29 publications

High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

High Sensitivity C- Reactive Protein Level in Acute Cerebrovascular Accident (Stroke) at a Tertiary Care Centre

Point-of-care optical biosensor platforms for stroke diagnostics with blood-based biomarkers

Blood-Based Biomarkers Are Associated with Different Ischemic Stroke Mechanisms and Enable Rapid Classification between Cardioembolic and Atherosclerosis Etiologies

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