Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease

Abstract

Serum adiponectin levels are significantly lower in NAFLD patients with elevated liver enzymes. Non-alcoholic steatohepatitis patients show lower levels of adiponectin with higher grades of inflammation.

Levels of Soluble CD40 Ligand and P-Selectin in Nonalcoholic Fatty Liver Disease

“…The abnormalities in glucose and lipid metabolism and also blood pressure that can potentially affect endothelial function are frequently accompanied by NAFLD [3,27]. Therefore, including only the subjects free from any confounding factor is an important feature of the present investigation.…”

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

“…In particular, the uncleaved (high molecular weight form) of adiponectin was found to suppress cytokine-induced NF-␤ activation in cardiac fibroblasts and endothelial cells, whereas the proteolytic cleavage product activated NF-␤ and thereby promoted expression of pro-inflammatory and adhesion molecule (Hattori et al, 2007;Tomizawa et al, 2008). Clinical studies revealed that plasma adiponectin levels were lower in patients with nonalcoholic fatty liver disease compared with healthy subjects and were inversely correlated with grade of inflammation and extent of liver injury (Musso et al, 2005;Pagano et al, 2005;Aygun et al, 2006;Targher et al, 2006;Wong et al, 2006). Consequently, replenishing adiponectin levels by its recombinant substitute attenuated steatosis in overnutrition, obesity, and insulin resistance but also ameliorated chronic liver injury induced by ethanol and carbon tetrachloride, suggesting that adiponectin may play a central role in the development of hepatic steatosis and fibrosis (Kamada et al, 2003;Xu et al, 2003).…”

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

“…In human patients with NAFLD, serum adiponectin levels were found to be decreased [24]. The transcriptional factor Forkhead/ winged helix (FOXO1) had been recently associated with NAFLD [25][26][27].…”