Serum levels of Glial fibrillary acidic protein in Chinese children with autism spectrum disorders

Wang, Jingwei; Zou, Qiuyan; Han, Renfeng; Li, Yupeng; Wang, Yulin

doi:10.1016/j.ijdevneu.2017.01.004

Cited by 16 publications

(12 citation statements)

References 30 publications

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“…However, the small study groups with only four children diagnosed with autism do not allow any conclusion to be drawn. These results differ from previous studies, in which elevated levels of GFAP were found in CSF [11] and serum [12] in children with autism compared to controls. However, none of the children with autism and PANS in our study had intellectual disability, while this was present in 70% of the children with autism reported in the 1990s [11].…”

Section: Discussioncontrasting

confidence: 99%

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No Neurochemical Evidence of Neuronal Injury or Glial Activation in Children with Paediatric Acute-onset Neuropsychiatric Syndrome

Johnson

Fernell

Gillberg

et al. 2020

Preprint

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Background Paediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by an acute onset of obsessive compulsive disorder, combined with at least two other neuropsychiatric symptoms with similarly acute onset. Diagnostic criteria also require that no specific medical aetiology is identified. Although there are no verified aetiological biomarkers, PANS is assumed to be a neuroinflammatory disorder with a possible autoimmune aetiology. Neurochemical markers such as neurofilament light (NfL, a neuronal injury marker) and glial fibrillary acidic protein (GFAP, an astrocytic activation marker) have not been published for this patient group.Methods Blood samples from 17 children meeting diagnostic criteria for PANS, after assessment at the Child Neuropsychiatry Centre, Sahlgrenska University Hospital, Gothenburg, Sweden, were analysed for serum concentrations of NfL and GFAP. Ten age-matched children without any neurological or psychiatric disorder served as a comparison group. Results No difference was found in mean NfL and mean GFAP serum concentrations between children with PANS and controls. NfL and GFAP concentrations did not correlate with disease duration between PANS onset and time of blood tests. Conclusion Neuronal injury and astrocyte activation do not seem to be a major event in PANS. The study group was small, and even if findings may be reassuring for parents and patients, they should be interpreted with caution and verified in larger cohort and possibly with other markers in both serum and CSF.

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Section: Discussioncontrasting

confidence: 99%

“…In one aetiological subgroup of children with autism, consisting of three children with a basal ganglia disorder, the highest GFAP levels were found [11]. Also a more recent study, using serum levels of GFAP, demonstrated elevated levels in children with autism compared to controls [12].…”

Section: Introductionmentioning

confidence: 86%

No Neurochemical Evidence of Neuronal Injury or Glial Activation in Children with Paediatric Acute-onset Neuropsychiatric Syndrome

Johnson

Fernell

Gillberg

et al. 2020

Preprint

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“…In our study serum GFAP levels were significantly increased in ASD patients, with a positive correlation found with CARS score showing severity of autism in all subjects. Wang et al also found increased levels of GFAP in the serum of autistic children (Wang et al, 2017). The GFAP findings in this study are in accordance with a previous postmortem study which found increased GFAP levels in the brain (Laurence and Fatemi, 2005).…”

Section: Discussionmentioning

confidence: 92%

Evaluation of serum Neuron‐specific enolase, S100B, myelin basic protein and glial fibrilliary acidic protein as brain specific proteins in children with autism spectrum disorder

Esnafoğlu¹,

Ayyıldız

Cırrık

et al. 2017

Intl J of Devlp Neuroscience

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“…The clinical heterogeneity in ASD children has encouraged increasing interest in biomarkers as potentially useful indicators for diagnosis and treatment. Recently, a number of studies have attempted to identify potential blood-based biomarkers based on neurophysiological and biochemical alterations, for example, brain-derived neurotrophic factor (BDNF) [ 39 – 41 ], neurotrophin-4 (NT-4) [ 41 ], serotonin (5-HT) [ 42 , 43 ], neopterin [ 44 ], and the glial fibrillary acidic protein [ 45 ]. However, no biomarkers to date have shown high sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 99%

Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder

Sriwimol

Limprasert

2018

BioMed Research International

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Alpha-synuclein (α-synuclein) and beta-synuclein (β-synuclein) are presynaptic proteins playing important roles in neuronal plasticity and synaptic vesicle regulation. To evaluate the association of these two proteins and autism spectrum disorder (ASD), we investigated the plasma α-synuclein and β-synuclein levels in 39 male children with ASD (2 subgroups: 25 autism and 14 pervasive developmental disorder-not otherwise specified (PDD-NOS)) comparing with 29 sex- and age-matched controls by using enzyme-linked immunosorbent assay (ELISA). We first determined the levels of these two proteins in the ASD subgroups and found that there were no significant differences in both plasma α-synuclein and β-synuclein levels in the autism and PDD-NOS groups. Thus, we could combine the 2 subgroups into one ASD group. Interestingly, the mean plasma α-synuclein level was significantly lower (P < 0.001) in the ASD children (10.82 ± 6.46 ng/mL) than in the controls (29.47 ± 18.62 ng/mL), while the mean plasma β-synuclein level in the ASD children (1344.19 ± 160.26 ng/mL) was significantly higher (P < 0.05) than in the controls (1219.16 ± 177.10 ng/mL). This is the first study examining the associations between α-synuclein and β-synuclein and male ASD patients. We found that alterations in the plasma α-synuclein and β-synuclein levels might be implicated in the association between synaptic abnormalities and ASD pathogenesis.

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Serum levels of Glial fibrillary acidic protein in Chinese children with autism spectrum disorders

Abstract: The data indicates that serum GFAP levels may be associated with severity of ASD among Chinese children, suggesting the hypothesis that increased serum levels of GFAP could be implicated in the pathophysiology of autism in Chinese children.

Cited by 16 publications

References 30 publications

No Neurochemical Evidence of Neuronal Injury or Glial Activation in Children with Paediatric Acute-onset Neuropsychiatric Syndrome

No Neurochemical Evidence of Neuronal Injury or Glial Activation in Children with Paediatric Acute-onset Neuropsychiatric Syndrome

Evaluation of serum Neuron‐specific enolase, S100B, myelin basic protein and glial fibrilliary acidic protein as brain specific proteins in children with autism spectrum disorder

Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder

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