2005
DOI: 10.2169/internalmedicine.44.428
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Serum Levels of Free Light Chain before and after Chemotherapy in Primary Systemic AL Amyloidosis

Abstract: Objective Immunoglobulin-related free light chains (FLCs) in serum have recently become quantitatively detectable using the nephelometric assay in plasma cell disorders, including multiple myeloma and AL amyloidosis. To investigate whether FLCs are useful as a diagnostic and therapeutic marker in Japanese patients with primary systemic AL amyloidosis, we determined these values in serum before and after chemotherapy.Patients and Methods The serum FLC analysis was carried out in 25 patients with primary systemi… Show more

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Cited by 22 publications
(14 citation statements)
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“…These assessments are usually obtained from blood and urine tests (such as immunofixation tests and measurements of the BNP, FLC and ALP levels, etc.) (18) and imaging examinations, including echography and CT (6). It is possible to more easily estimate the presence of a hematologic CR if monoclonal protein is detectable before treatment (6), although the im- munofixation tests conducted in our patient were negative in both the serum and urine.…”
Section: Discussionmentioning
confidence: 87%
“…These assessments are usually obtained from blood and urine tests (such as immunofixation tests and measurements of the BNP, FLC and ALP levels, etc.) (18) and imaging examinations, including echography and CT (6). It is possible to more easily estimate the presence of a hematologic CR if monoclonal protein is detectable before treatment (6), although the im- munofixation tests conducted in our patient were negative in both the serum and urine.…”
Section: Discussionmentioning
confidence: 87%
“…The most important change was the development of the Ig free light-chain assay, which allowed a more accurate determination of hematological response. [28][29][30] Reports on the efficacy of melphalan and prednisone may underestimate the true response rates because none of the studies included light-chain measurements. 31,32 Response rates with novel agent-based therapy are extremely high and rival those seen with auto-SCT.…”
Section: Discussionmentioning
confidence: 99%
“…No abnormal findings were found on either the electrocardiogram or echocardiogram, and there was no amyloid deposition in the biopsied gastroduodenal mucosa. Quantitative assay of serum free light chains (FLCs) revealed an increase in λ-chain (48.7 mg/L, normal 5.7-26.3 mg/L) and a slight decrease in the κ/λ ratio (0.24, normal 0.26-1.65) [7]. At age 50 she received two courses of VAD (vincristine, doxorubicin and dexamethasone) and subsequent HDM/SCT [2,8] At age 52 she underwent surgical removal of the involved lymph nodes.…”
Section: Case Reportmentioning
confidence: 99%