Serum levels of fractalkine are associated with markers of insulin resistance in gestational diabetes

Ebert, Thomas; Hindricks, Janka; Kralisch, Susan; Lössner, Ulrike; Jeßnitzer, Beate; Richter, J; Blüher, Matthias; Stümvoll, Michael; Faßhauer, Mathias

doi:10.1111/dme.12451

Cited by 16 publications

(10 citation statements)

References 22 publications

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“…(34, 39) Previous studies found that fractalkine, osteopontin and vaspin are associated with insulin resistance and obesity. (2,10,36) However, no baseline differences in circulating levels of cytokines were found between women with MetS and controls in our study. Furthermore, we found no correlation between insulin sensitivity and levels of these cytokines.…”

Section: Baselinementioning

confidence: 53%

“…In humans, fractalkine has been proven to modulate monocyte adhesion in adipose tissue, thereby influencing chronic inflammation processes,(36) and is independently associated with markers of insulin resistance (HOMA-IR). (10) Omentin is a cytokine mainly secreted by visceral adipose tissue. Circulating omentin levels are negatively correlated with insulin resistance and are decreased in obesity and type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Exercise Improves Insulin Sensitivity in the Absence of Changes in Cytokines

Verheggen¹,

Poelkens

Roerink

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose. The benefits of aerobic exercise training on insulin sensitivity in subjects with the metabolic syndrome (MetS) are, at least in part, associated with changes in cytokines. Recent studies identified novel cytokines (e.g. fractalkine, omentin and osteopontin) that are strongly involved in glucose homeostasis and therefore potentially contribute in the exercise-induced changes in insulin sensitivity. Therefore, we aim to examine changes in skeletal muscle RNA expression and plasma levels of novel cytokines after exercise training, and correlate these changes to the exercise-induced changes in insulin sensitivity. Methods. Women with the metabolic syndrome (MetS, n=11) and healthy women (n=10) participated in a 6-month aerobic exercise training intervention (3/week, 45min per session at 65%-85% of individual heart rate reserve). Before and after training, we examined insulin sensitivity (M-value during hyperinsulinemic euglycaemic clamp), circulating blood levels of cytokines (venous blood sample; leptin, adiponectin, omentin, fraktalkin, osteopontin). Skeletal muscle RNA-expression of these cytokines (muscle biopsy) was examined in two subgroups (MetS n=6; healthy women n=6). Results. At baseline, plasma levels of omentin (85.8±26.2ng/ml) and adiponectin (5.0±1.7μg/ml) levels were significantly higher in controls compared to MetS (51.1±27.1; 3.6±1.1 respectively), and leptin levels were lower in controls (18.7±11.5ng/ml vs 53.0±23.5).M-value was significantly higher in controls (8.1±1.9mg/kg/min) than in MetS (4.0±1.7).Exercise training significantly improved M-values in both groups (P<0.01). Exercise training did not alter plasma and skeletal muscle RNA-expression levels of cytokines, whilst no correlation was observed between changes in cytokine level/RNA-expression and M-values (P>0.05). Conclusion. Whilst exercise training successfully improves insulin sensitivity in MetS andhealthy women, we found no change in plasma and mRNA expression levels of novel cytokines.

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Section: Baselinementioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Exercise Improves Insulin Sensitivity in the Absence of Changes in Cytokines

Verheggen¹,

Poelkens

Roerink

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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“…To quantitate systemic insulin sensitivity and assess tissue-specific effects, we performed hyperinsulinemic-euglycemic clamp studies in these mice. As seen in Figure 3, B-D, the glucose infusion rate was increased 56% by chronic FKN-Fc administration, and this systemic effect was due to increased hepatic insulin sensitivity ( Figure 3C) with no change CX3CL1 extracellular domain and is readily detected in mouse and human blood (24,25). Cellular FKN effects are largely mediated through its cognate receptor CX3CR1 (26).…”

Section: Introductionmentioning

confidence: 92%

Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function

Riopel

Seo

Bandyopadhyay

et al. 2018

Journal of Clinical Investigation

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“…The study design has recently been described (10,11). In brief, a 75 g, 2 h oral glucose tolerance test (OGTT) was performed in all participants according to the criteria of the American Diabetes Association (12).…”

Section: Study Participantsmentioning

confidence: 99%

Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls

Ebert¹,

Kralisch²,

Wurst³

et al. 2015

European Journal of Endocrinology

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Objective: Betatrophin has recently been introduced as a novel adipokine/hepatokine, which promotes pancreatic b cell proliferation and improves glucose tolerance in several mouse models of insulin resistance. However, regulation of betatrophin in gestational diabetes mellitus (GDM), as well as its association with markers of obesity, such as glucose and lipid metabolism, inflammation, and renal function, have not been elucidated. Design and methods: Circulating betatrophin was quantified in 74 women with GDM and 74 healthy and gestational age-matched controls by ELISA. In a subset of the study population comprising of 85 patients (41 previous controls, 44 previous women with GDM), postpartum betatrophin levels were measured in a follow-up study. Results: Median (interquartile range) serum betatrophin levels were higher in women with GDM (1.79 (0.53) mg/l) as compared to non-diabetic pregnant controls (1.58 (0.44) mg/l) (PZ0.002). In multivariate analysis, GDM status was an independent and positive predictor of circulating betatrophin (PZ0.001). Furthermore, betatrophin levels were significantly higher during gestation (1.70 (0.53) mg/l) as compared to postpartum levels (1.55 (0.66) mg/l) (PZ0.028). Moreover, postpartum irisin remained a positive and independent predictor of postpartum betatrophin concentrations. Conclusions: Women with GDM have significantly higher betatrophin levels as compared to healthy pregnant controls and GDM status positively predicts circulating betatrophin. Furthermore, postpartum levels are significantly lower as compared to betatrophin concentrations during pregnancy. Moreover, irisin is a significant predictor of postpartum betatrophin levels.

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Serum levels of fractalkine are associated with markers of insulin resistance in gestational diabetes

Abstract: Circulating fractalkine is not different between women with gestational diabetes and control subjects, but the adipokine is independently associated with markers of insulin resistance and proinflammatory progranulin in pregnancy.

Cited by 16 publications

References 22 publications

Exercise Improves Insulin Sensitivity in the Absence of Changes in Cytokines

Exercise Improves Insulin Sensitivity in the Absence of Changes in Cytokines

Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function

Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls

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