Serum levels of different forms of soluble CD38 antigen in burned patients

Lebedev, M.Ju; Егорова, Н. Ю.; Шолкина, М. Н.; Vilkov, S.A; Baryshnikov, AY; Novikov, V. V.

doi:10.1016/j.burns.2004.01.029

Cited by 13 publications

(10 citation statements)

References 22 publications

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“…In addition to the existence of a membrane form, a soluble form of CD38 (sCD38) was identified in cell culture supernatant of activated T lymphocytes, in several tumor cell lines, and in vivo in normal (fetal serum and amniotic fluid) and pathological [serum and ascites from patients with multiple myeloma, and serum from patients with acquired immune deficiency syndrome (AIDS)] biological fluids (103,208).…”

Section: A Cd38mentioning

confidence: 99%

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

Malavasi¹,

Deaglio²,

Funaro³

et al. 2008

Physiological Reviews

741

794

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The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. These reaction products are essential for the regulation of intracellular Ca(2+), the most ancient and universal cell signaling system. The entire family of enzymes controls complex processes, including egg fertilization, cell activation and proliferation, muscle contraction, hormone secretion, and immune responses. Over the course of evolution, the molecules have developed the ability to interact laterally and frontally with other surface proteins and have acquired receptor-like features. As detailed in this review, the loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications in mice. CD38 is a powerful disease marker for human leukemias and myelomas, is directly involved in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and the development of diabetes. Here, the data concerning diseases are examined in view of potential clinical applications in diagnosis, prognosis, and therapy. The concluding remarks try to frame all of the currently available information within a unified working model that takes into account both the enzymatic and receptorial functions of the molecules.

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Section: A Cd38mentioning

confidence: 99%

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

Malavasi¹,

Deaglio²,

Funaro³

et al. 2008

Physiological Reviews

741

794

View full text Add to dashboard Cite

show abstract

“…Indeed, it may act as a receptor when surface expressed and as an enzyme when internalized upon request or during its cytoplasmic transit [103]. There is no current evidence that this model may also hold true for CD157, mainly because of its GPI anchor, nor has the role of soluble CD38 [104,105] and CD157 [106] been analyzed in any great detail.…”

Section: Discussionmentioning

confidence: 99%

The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes

Deaglio

Malavasi

2006

Purinergic Signalling

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Human CD38 is the mammalian prototype of a family of phylogenetically conserved proteins which share structural similarities and enzymatic activities involved in the production of an intracellular second messenger with calcium mobilizing effects. Engagement of CD38 by agonistic monoclonal antibodies and the CD31 ligand initiates a cytoplasmic signaling cascade involving tyrosine phosphorylation of the proto-oncogene c-cbl and of the extracellular regulated kinase 1 of 2 complex. Further requirements for signal transduction include a privileged localization within the cholesterol-rich areas of the plasma membrane and physical association with specialized surface receptors. CD38-mediated signals are crucial in heterotypic cell adhesion and migration as well as in the activation of proliferation/survival programs by normal and neoplastic cells. Here we review the most recent literature on this complex topic and attempt to formulate a single model reconciling the enzymatic and receptorial activities of CD38.

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“…For example, shedding of membrane differentiation molecules from immune cell membranes is a common posttranslational protein modification in normal conditions and inflammation. As a result, the level of soluble differentiation molecules and histocompatibility molecules is elevated in biological fluids [22][23][24]. With regard to allergies, the most known soluble protein biomarkers are IgE and IgG antibodies specific for the disease-causing allergens, cytokines, enzymes, and other proteins, such as soluble differentiation molecules of the immune cells, i.e., membrane protein markers.…”

Section: Protein Biomarkers and Their Role In Asthmamentioning

confidence: 99%

Protein Biomarkers in Asthma

Karaulov

Garib

et al. 2018

Int Arch Allergy Immunol

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Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.

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Serum levels of different forms of soluble CD38 antigen in burned patients

Cited by 13 publications

References 22 publications

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes

Protein Biomarkers in Asthma

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