Serum levels of cytokines in chronic liver diseases

Tilg, Herbert; Wilmer, A.; Vogel, Wolfgang; Herold, Manfred; Nölchen, B; Judmaier, G; Huber, Christoph

doi:10.1016/0016-5085(92)91122-k

Cited by 697 publications

(464 citation statements)

References 46 publications

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“…Furthermore, elevated serum adiponectin level might be the consequence of hepatocyte injury. Actually, patients with cirrhosis are characterized by a chronic inflammatory state with elevated plasma levels of several cytokines [34]. In this case, high serum adiponectin might play a protective role in hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

et al. 2008

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Purpose Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis B-related liver disease.Methods Serum adiponectin and hepatitis B viral factors were cross-sectionally assayed in 280 patients with chronic hepatitis B virus (HBV) infection including 120 patients with chronic HBV infection, 40 patients with cirrhosis, and 120 patients with hepatocellular carcinoma (HCC); 116 healthy adults were used as controls. The dynamics of serum adiponectin level was also studied longitudinally in 25 patients with hepatitis B e antigen (HBeAg) seroconversion (SC). Results We found that serum adiponectin level in patients with chronic HBV infection was similar to that in healthy controls and was significantly lower than patients with cirrhosis and HCC. In univariate analysis, high serum adiponectin level significantly correlated with the presence of HBV-related cirrhosis or HCC, abnormal serum ALT level, and HBV genotype C. Multivariate analysis revealed that high serum adiponectin level significantly correlated with the development of HCC. Serum adiponectin levels remained stationary in patients experiencing HBeAg SC. Conclusions Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC.

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Section: Discussionmentioning

confidence: 99%

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

et al. 2008

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“…11,[16][17][18][19]32 It has been recently shown FIG 7. Levels of TNF-a mRNA (as a ratio to b-actin) in PBMC that production of TNF-a in the liver takes place not and in the liver in patients with chronic hepatitis C at the end of only in nonparenchymal cells but also in hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor ? gene expression and the response to interferon in chronic hepatitis C

et al. 1996

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Tumor necrosis factor a (TNF-a) is a cytokine with infectious agents and has been shown to exert direct pleiotropic properties that is induced in a variety of antiviral effects. [3][4][5] Although low levels of TNF-a can pathological situations including viral infections. In this contribute to cell protection, excessive amounts may work, we analyzed the expression of TNF-a gene in pa-cause cell damage. 2,6 tients with chronic hepatitis C. Serum TNF-a levels wereThe biosynthesis of TNF-a is tightly regulated by found to be elevated in all chronic hepatitis C patients transcriptional and post-transcriptional mechanisms. 1 including those cases presenting sustained biochemical A variety of viruses have been shown to induce the remission of the disease after interferon therapy. Unexpression of TNF-a in vitro. [6][7][8][9] The accumulation of treated patients with chronic hepatitis C showed in-TNF-a messenger RNA (mRNA) that occur in virus- ever, only about 50% of the treated patients respond to IFN-a therapy with normalization of serum transTumor necrosis factor a (TNF-a) is a cytokine, proaminases, and half of these patients relapse after interduced primarily by activated monocytes and lymphoruption of the treatment. 23 cytes, that possesses pleiotropic properties. 1,2 It particiLittle is known about the mechanisms determining pates in the induction of the immune response to the severity of the liver damage and the response to IFN-a in HCV infection. In this paper, we have studied the presence of HCV RNA in the liver or in PBMC is

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“…Several proinflammatory cytokines, including TNF-a and IL-1b, play important roles in the pathophysiology of chronic inflammatory disease, including chronic hepatitis (Tilg et al, 1992;Gonzalez-Amaro et al, 1994). IkB kinase-dependent NF-kB signaling pathways are reported to link inflammation to tumorigenesis (Greten et al, 2004;Pikarsky et al, 2004;Karin and Greten, 2005).…”

Section: Expression Of Aid In Human Hepatocytes Via Nf-jb Y Endo Et Almentioning

confidence: 99%

Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling

et al. 2007

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Activation-induced cytidine deaminase (AID) is involved in somatic DNA alterations of the immunoglobulin gene for amplification of immune diversity. The fact that constitutive expression of AID in mice causes tumors in various organs, including lymphoid tissues and lungs, suggests the important role of the aberrant editing activity of AID on various tumor-related genes for carcinogenesis. AID expression, however, is restricted to activated B cells under physiological conditions. We demonstrate here that ectopic AID expression is induced in response to tumor necrosis factor-a stimulation in cultured human hepatocytes. The proinflammatory cytokine-mediated expression of AID is achieved by IjB kinase-dependent nuclear factor (NF)-jB signaling pathways. Hepatitis C virus, one of the leading causes of hepatocellular carcinoma (HCC), enhanced AID expression via NF-jB activation through expression of viral core protein. The aberrant expression of AID in hepatoma-derived cells resulted in accumulation of genetic alterations in the c-myc and pim1 genes, suggesting that inappropriate expression of AID acts as a DNA mutator that enhances the genetic susceptibility to mutagenesis in human hepatocytes. Our current findings indicate that the inappropriate expression of AID is induced by proinflammatory cytokine stimulation and may provide the link between hepatic inflammation and the development of HCC.

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Serum levels of cytokines in chronic liver diseases

Cited by 697 publications

References 46 publications

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

Tumor necrosis factor ? gene expression and the response to interferon in chronic hepatitis C

Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling

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