Serum Levels of Clara Cell 10-kDa Protein Are Decreased in Patients with Asthma

Shijubo, Noriharu; Itoh, Yoshio; Yamaguchi, Tetsuji; Sugaya, Fumiko; Hirasawa, Michio; Yamada, Toshiyuki; Kawai, Tadashi; Abe, Shosaku

doi:10.1007/pl00007626

Cited by 107 publications

(103 citation statements)

References 32 publications

(48 reference statements)

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“…However, that study only looked at short-term effects. Work in humans is consistent with our observations that CCSP is downregulated in asthma and in areas of mucus metaplasia (2,24,32,46,47). It is interesting that, although IL-13 downregulates CCSP, interferon gamma is known to upregulate CCSP (39).…”

Section: Discussionsupporting

confidence: 89%

Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation

Homer¹,

Zhu²,

Cohn³

et al. 2006

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionsupporting

confidence: 89%

Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation

Homer¹,

Zhu²,

Cohn³

et al. 2006

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Reduced CC16 concentrations may be indicative of asthmatic changes. Asthmatic patients have been shown to be characterized by lower levels of phospholipase A2, towards which the CC16 protein acts as an inhibitor [40], and reduced levels of CC16 protein [41,42]. A significant increase of the leucocyte count in BALF and numerous focal aggregates of alveolar macrophages observed in the microscopic images of the lungs also point to the immunoinflammatory processes occurring in the lungs of the exposed animals.…”

Section: Discussionmentioning

confidence: 97%

Toxic effect in the lungs of rats after inhalation exposure to benzalkonium chloride

Świercz¹,

Hałatek²,

Stetkiewicz³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Background: Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) toxic to microorganisms. Inhalation is one of the major possible routes of human exposure to BAC. Materials and Methods: Experiments were performed on female Wistar rats. The rats were exposed to aerosol of BAC water solution at the target concentration of 0 (control group) and 35 mg/m 3 for 5 days (6 h/day) and, after a 2-week interval, the animals were challenged (day 21 ) with BAC aerosol at the target concentration of 0 (control group) and 35 mg/m 3 for 6 h. Results: Compared to the controls, the animals exposed to BAC aerosol were characterized by lower food intake and their body weight was significantly smaller. As regards BAC-exposed group, a significant increase was noted in relative lung mass, total protein concentration, and MIP-2 in BALF both directly after the termination of the exposure and 18 h afterwards. Significantly higher IL-6 and IgE concentrations in BALF and a decrease in the CC16 concentration in BALF were found in the exposed group immediately after the exposure. The leukocyte count in BALF was significantly higher in the animals exposed to BAC aerosol compared to the controls. In the lungs of rats exposed to BAC the following effects were observed: minimal perivascular, interstitial edema, focal aggregates of alveolar macrophages, interstitial mononuclear cell infiltrations, thickened alveolar septa and marginal lipoproteinosis. Conclusion: Inhalation of BAC induced a strong inflammatory response and a damage to the blood-air barrier. Reduced concentrations of CC16, which is an immunosuppressive and anti-inflammatory protein, in combination with increased IgE concentrations in BALF may be indicative of the immuno-inflammatory response in the animals exposed to BAC aerosol by inhalation. Histopathological examinations of tissue samples from the BAC-exposed rats revealed a number of pathological changes found only in the lungs.

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“…Most [19][20][21][22][23][24] but not all 51 studies in children or adults have found an inverse association between serum levels of CC16 and prevalent asthma or its related phenotypes. In a recent cross-sectional study of 203 adult elite athletes, low serum levels of CC16 were also associated with a history of frequent upper respiratory tract infections.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 For instance, respiratory disorders that increase the epithelial permeability (e.g., acute respiratory distress syndrome, 16 exposure to proinflammatory agents, 17 or severe chest trauma 18 ) have been associated with higher serum levels of CC16. On the other hand, respiratory illnesses leading to small airway inflammation (e.g., asthma, [19][20][21][22][23][24] exposure to tobacco smoke, [25][26][27] or chronic obstructive pulmonary disease 25,[27][28][29] ) have been associated with lower serum levels of CC16.…”

mentioning

confidence: 99%

Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower Respiratory Tract Infections in Infancy

Rosas‐Salazar

Gebretsadik

Carroll

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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Background: Infants with lower respiratory tract infections (LRTIs) are at an increased risk of developing childhood wheezing illnesses (including asthma), but it is not currently possible to predict those at risk for these long-term outcomes. The current objective was to examine whether urine levels of club cell 16-kDa secretory protein (CC16) at the time of an infant LRTI are associated with the development of childhood wheezing illnesses. Methods: Prospective study of 133 previously healthy infants enrolled during a healthcare visit for a LRTI and followed longitudinally for childhood wheezing illnesses. Urine levels of CC16 at the time of enrollment were measured after validating a commercially available enzyme-linked immunosorbent assay kit for serum. The outcome of interest was parental report of subsequent childhood wheeze (defined as ‡1 episode of wheezing following the initial LRTI) at the 1-year follow-up visit. Logistic regression was used for the main analysis. Results: The median (interquartile range) urine levels of CC16 (ng/mg of creatinine) at the time of an infant LRTI were 11.1 (7.7-20.1) for infants with subsequent childhood wheeze and 13.4 (8.3-61.1) for those without ( p = 0.11). In the main multivariate analysis using a logarithmic transformation of the urine levels of CC16, a twofold increase in urine levels of CC16 was associated with *30% decreased odds (OR = 0.74 [95% confidence interval (CI) 0.56-0.98], p = 0.04) of subsequent childhood wheeze after adjustment for potential confounders. Conclusions: An inverse association was found between urine levels of CC16 at the time of an infant LRTI and the odds of subsequent childhood wheeze. Urine CC16 may be a useful biomarker of the development of childhood wheezing illnesses after LRTIs in infancy.

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Serum Levels of Clara Cell 10-kDa Protein Are Decreased in Patients with Asthma

Cited by 107 publications

References 32 publications

Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation

Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation

Toxic effect in the lungs of rats after inhalation exposure to benzalkonium chloride

Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower Respiratory Tract Infections in Infancy

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