Serum Levels of Carcinoembryonic Antigen in Patients with Type 2 Diabetes

Zayed, Ayman A.; Beano, Abdallah; Amer, Farah; Maslamani, Jumana M.; Zmaili, Mohammad; Al-Khudary, Talha H.; Momani, Munther; Yousef, Al-Motassem

doi:10.4158/ep161221.or

Cited by 15 publications

(15 citation statements)

References 30 publications

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“…There is also scant data about CEA for colorectal cancer patients with DM [ 20–23 ]. One study showed a statistically significant association between increased CEA level and DM and a correlation between CEA serum level and HbA 1c level.…”

Section: Discussionmentioning

confidence: 99%

Survival and Glycemic Control in Patients With Colorectal Cancer and Diabetes Mellitus

et al. 2018

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Aim:The impact of diabetes mellitus (DM) on survival in patients with colorectal cancer and the impact of colorectal cancer on glycemic control were examined.Materials & methods:Patients with colorectal cancer with and without DM were matched 1:1 (2007–2015). Characteristics were compared between the two groups and survival assessed with the Kaplan–Meier method. Mixed models compared hemoglobin A1c and glucose levels over time.Results:In both groups, glucose values decreased during the year following cancer diagnosis (p < 0.001). 5-year overall survival was 56% (95% CI: 42–68%) for DM patients versus 57% (95% CI: 43–69%) for non-DM patients (p = 0.62).Conclusion:DM did not adversely impact survival of patients with colorectal cancer. Colorectal cancer did not affect glycemic control.

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Section: Discussionmentioning

confidence: 99%

Survival and Glycemic Control in Patients With Colorectal Cancer and Diabetes Mellitus

et al. 2018

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“… 14 Moreover, a previous study reported an association between CEA levels and oxidative stress markers. 6 Hyperglycemia can influence free radical formation, which may eventually lead to increased oxidative stress. Severe oxidative stress along with poor glycemic control may induce increased CEA expression.…”

Section: Discussionmentioning

confidence: 99%

The serum levels of tumor marker CA19-9, CEA, CA72-4, and NSE in type 2 diabetes without malignancy and the relations to the metabolic control

Shang

Song

et al. 2017

SMJ

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Objectives:To investigate whether there is a difference in carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), carbohydrate antigen 72-4 (CA72-4), and neuron-specific enolase (NSE) between diabetic and non-diabetic patients.Methods:A retrospective analysis was performed in 268 type 2 diabetic patients and 95 non-diabetic ones, and their serum levels of CA19-9, CEA, CA72-4, and NSE were compared in our endocrine ward at the Tianjin Fourth Central Hospital, Tianjin, China during the period from January to June 2015. The diabetic patients were divided into 4 groups based on glycosylated hemoglobin (HbA1c) levels to investigate the relationship between levels of tumor markers and glucose status.Results:Diabetic patients had higher levels of tumor markers than non-diabetic subjects (CA19-9: 13.0 versus 7.25U/mL, p=0.000; CEA: 2.55 versus 2.25 ng/mL, p=0.012; CA72-4: 1.95 versus 1.50U/mL, p=0.001; NSE: 11.64 versus 10.22ng/mL, p=0.000). CA19-9 levels increased in a stepwise manner with poor diabetes status. CEA levels were increased in patients with HbA1c ≥9% and CA72-4 elevation was predominant in patients with poor glycemic control (HbA1c ≥11%). NSE levels were not associated with metabolic parameters.Conclusion:Serum levels of CA19-9, CEA, CA72-4, and NSE were elevated in type 2 diabetes; however, only CA19-9, CEA, and CA72-4 levels were associated with hyperglycemia.

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“…It is also expressed in nonmalignant conditions, such as aging, smoking, chronic renal failure and some chronic in ammatory disease [5]. Previous studies found serum CEA level could affect cardiometabolic diseases, including acute coronary syndrome [6], carotid atherosclerosis [7], diabetes [8][9][10], and obesity [11,12].…”

Section: Introductionmentioning

confidence: 99%

Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among Chinese male population: two cohort studies

Liu

et al. 2020

Preprint

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Purpose: Previous studies have shown that serum carcinoembryonic antigen (CEA) was independently associated with metabolic syndrome (MetS) risk. However, these studies were mainly cross-sectional analyses and cause has not been clarified. In the current study, we conducted two bidirectional cohort studies to investigate the bidirectional associations between CEA and MetS using a Chinese male sample cohort.Methods: The initial longitudinal cohort included 9,629 Chinese males from January 2010 to December 2015. Two bidirectional cohorts were conducted in the study: subcohort A (from CEA to MetS, n=6,439) included participants without MetS at baseline to estimate the risk of developing incident MetS; subcohort B (form MetS to CEA, n=8,533) included participants without elevated CEA level (Hyper-CEA) at baseline to examine the risk of developing incident Hyper-CEA. Hazard ratios were estimated using Cox proportional hazards models.Results: In subcohort A, the incidence densities of MetS were 85.47 and 99.25 per 1000 person-years with and without Hyper-CEA, respectively. Comparing without Hyper-CEA at baseline, participants with Hyper-CEA had a 0.89 (95% CI, 0.71 to 1.12)-fold hazard ratio of developing incidence MetS (P=0.326). In subcohort B, the incidence densities of Hyper-CEA were 33.42 and 29.13 per 1000 person-years for those with and without MetS, respectively. Participants with MetS had no significantly associated with incident Hyper-CEA (hazard ratio, 1.02; 95% CI, 0.84 to 1.22; P=0.864) in the general Chinese participants. Meanwhile, in the stratified analysis, MetS was might significantly associated with increased incident Hyper-CEA in men with age > 65-year and nonsmoking.Conclusion: CEA has no association with incident MetS. CEA should be interpreted carefully in MetS patients. Meanwhile, we need pay more attention to MetS in nonsmoking elderly men. They might have a higher risk of developing cancer.

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Serum Levels of Carcinoembryonic Antigen in Patients with Type 2 Diabetes

Cited by 15 publications

References 30 publications

Survival and Glycemic Control in Patients With Colorectal Cancer and Diabetes Mellitus

Survival and Glycemic Control in Patients With Colorectal Cancer and Diabetes Mellitus

The serum levels of tumor marker CA19-9, CEA, CA72-4, and NSE in type 2 diabetes without malignancy and the relations to the metabolic control

Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among Chinese male population: two cohort studies

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