Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

Guimarães, Lísia Rejane; Jacka, Felice N.; Gama, Clarissa Severino; Berk, Michael; Leitão-Azevedo, Carmen Lúcia; Abreu, Martha Guerra Belmonte de; Lobato, Maria Inês Rodrigues; Andreazza, Ana Cristina; Ceresér, Keila Maria Mendes; Kapczinski, Flávio; Belmonte-de-Abreu, Paulo Silva

doi:10.1016/j.pnpbp.2008.06.004

Cited by 38 publications

(23 citation statements)

References 26 publications

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“…Factors such as diet and level of physical activity can substantially contribute to alterations in inflammatory markers. 11,38,39 The excessive incidence of medical conditions in both BD and SZ is increasingly recognized. 9 The majority of these conditions are related to inflammation, especially cardiovascular illness, obesity and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…9 The excessive cardiovascular mortality associated with SZ and BD is attributed in part to an increased risk of the modifiable atherosclerotic risk factors: obesity, smoking, diabetes, hypertension and dyslipidaemia. [10][11][12] Inflammation is a mechanism that plays a part not only in atherosclerosis but also in different neuropsychiatric disorders, where it is involved in complex and reciprocal interactions with neurotrophins and oxidative stress. Considering these interactions, a Systemic Toxicity Index for mood episodes has recently been proposed to study neurotrophins, oxidative stress markers and inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

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Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Kunz¹,

Ceresér²,

Goi³

et al. 2011

Rev. Bras. Psiquiatr.

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Objective: Previous reports suggest that cytokines act as potential mediators of the interaction between the immune and neuroendocrine systems, and that a proinflammatory state may be associated with bipolar disorder and schizophrenia. The aim is to compare cytokine levels in both disorders. Method: Twenty euthymic bipolar disorder patients, 53 chronic stabilized schizophrenia patients and 80 healthy controls were recruited. Subjects were all non-smokers and non-obese. Cytokines TNF-α, IL-6, and IL-10 were examined by sandwich ELISA. Results: IL-6 levels were increased in schizophrenia patients when compared to controls (p < 0.0001) and euthymic bipolar disorder patients (p < 0.0001). IL-6 levels were no different in controls compared to euthymic bipolar disorder patients (p = 0.357). IL-10 was lower in controls compared to schizophrenia patients (p = 0.001) or to bipolar disorder patients (p = 0.004). There was no significant difference in TNF-α serum levels among the groups (p = 0.284). Gender-based classification did not significantly alter these findings, and no correlation was found between the antipsychotic dose administered and cytokine levels in patients with schizophrenia. Discussion: These findings evidence a chronic immune activation in schizophrenia. Bipolar disorder seems to present an episode-related inflammatory syndrome. Increased anti-inflammatory factor IL-10 in bipolar disorder and schizophrenia suggests different patterns of inflammatory balance between these two disorders. Results further support the need to investigate cytokines as possible biomarkers of disease activity or treatment response.Descriptors: Bipolar disorder; Schizophrenia; Interleukin-6; Interleukin-10; Tumor necrosis factor-alpha (p = 0,284 Resumo Objetivo: Pesquisas sugerem as citocinas como potenciais mediadores da interação entre os sistemas imune e neuroendócrino, e que existe um estado pró-inflamatório associado com transtorno bipolar e esquizofrenia. O objetivo deste estudo é comparar os níveis de citocinas entre os dois distúrbios. Método: Vinte pacientes com transtorno bipolar eutímicos, 53 pacientes com esquizofrenia crônica estabilizados e 80 controles saudáveis foram recrutados. Todos os indivíduos eram não-fumantes e não-obesos. As citocinas TNF-α, IL-6 e IL-10 foram examinadas por ELISA sanduíche. Resultados: A IL-6 estava aumentada nos pacientes com esquizofrenia quando comparados aos controles (p < 0,0001) e aos pacientes bipolares eutímicos (p < 0,0001). Os níveis de IL-6 não foram diferentes nos controles em comparação com pacientes com transtorno bipolar eutímicos (p = 0,357). Os níveis de IL-10 foram menores nos controles quando comparados aos pacientes com esquizofrenia (p = 0,001) ou aos bipolares (p = 0,004). Não houve diferença significativa nos níveis séricos de TNF-α entre os grupos

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Kunz¹,

Ceresér²,

Goi³

et al. 2011

Rev. Bras. Psiquiatr.

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“…While fasting is known to increase BDNF levels in brain [51,52], this effect for serum in healthy individuals has not been clearly shown. In addition, studies of long term fasting on serum BDNF levels have yielded conflicting results [53,54].…”

Section: Discussionmentioning

confidence: 99%

Stimulatory Effect of Whole Coffee Fruit Concentrate Powder on Plasma Levels of Total and Exosomal Brain-Derived Neurotrophic Factor in Healthy Subjects: An Acute Within-Subject Clinical Study

Reyes-Izquierdo¹,

Argumedo²,

Shu³

et al. 2013

FNS

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A pilot study by Reyes [1] previously showed that ingestion of single dose of whole coffee fruit concentrate (WCFC) powder increased blood levels of brain derived neurotrophic factor (BDNF) during the first 60 minutes after ingestion. In the present report, we performed a single dose, placebo-controlled, within-subject study to confirm and further investigate this effect. Twenty healthy subjects with ages ranging from 25 to 35 participated in this study. All fasted and resting subjects received placebo on Day 1, WCFC on Day 2, and a cup of freshly brewed coffee on Day 3. Treatment with WCFC resulted in a statistically significant increase in plasma BDNF compared to placebo (p = 0.0073) or coffee (p = 0.0219) during first 60 minutes. In addition, e isolated exosomes from serum and found that they contained BDNF. Furthermore, oral WCFC consumption acutely increased BDNF levels in serum exosomes. In summary, all presented results justify further clinical investigation of WCFC as a tool to manage BDNF-dependent health conditions.

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“…may predict weight gain associated with antipsychotic treatment (Lane et al, 2006;Tsai et al, 2011;Zai et al, 2012;Zhang et al, 2007Zhang et al, , 2008. In addition, it has been found that life style modification to reduce body weight increases BDNF level in non-diabetic schizophrenia subjects (Guimaraes et al, 2008;Kuo et al, 2013). BDNF level and its polymorphisms are also known to influence treatment response and adverse effects associated with antipsychotics.…”

Section: Neurotrophinsmentioning

confidence: 99%

Refining and integrating schizophrenia pathophysiology – Relevance of the allostatic load concept

Misiak

Frydecka

Zawadzki

et al. 2014

Neuroscience & Biobehavioral Reviews

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Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

Cited by 38 publications

References 26 publications

Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Stimulatory Effect of Whole Coffee Fruit Concentrate Powder on Plasma Levels of Total and Exosomal Brain-Derived Neurotrophic Factor in Healthy Subjects: An Acute Within-Subject Clinical Study

Refining and integrating schizophrenia pathophysiology – Relevance of the allostatic load concept

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Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

Cited by 38 publications

References 26 publications

Serum levels of IL-6, IL-10 and TNF-&#945; in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Serum levels of IL-6, IL-10 and TNF-&#945; in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Stimulatory Effect of Whole Coffee Fruit Concentrate Powder on Plasma Levels of Total and Exosomal Brain-Derived Neurotrophic Factor in Healthy Subjects: An Acute Within-Subject Clinical Study

Refining and integrating schizophrenia pathophysiology – Relevance of the allostatic load concept

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Product

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Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance