Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-<i>α</i>, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

Mercado, Mónica Vázquez-Del; Núñez-Atahualpa, Lourdes; Figueroa-Sánchez, Mauricio; Gómez-Bañuelos, Eduardo; Rocha-Muñoz, Alberto Daniel; Martín-Márquez, Beatriz Teresita; Corona-Sánchez, Esther Guadalupe; Martínez-García, Erika Aurora; Macias-Reyes, Hector; González-López, Laura; Gámez-Nava, Jorge I.; Navarro-Hernández, Rosa Elena; Nuñez-Atahualpa, María Alejandra; J., Andrade-Garduño

doi:10.1155/2015/342649

Cited by 34 publications

(22 citation statements)

References 48 publications

(44 reference statements)

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“…In our population, we found a significant correlation between c-IMT and both ACPA and anti-CarP levels. Published data report an association with ACPA positivity and risk for CV events in RA [26]. Thus, the data reported in our study are in line with previous findings but, for the first time, extend the association of c-IMT to a new subset of autoantibodies (i.e.…”

Section: Discussionsupporting

confidence: 93%

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Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

Pecani

Ciciarello

Colasanti

et al. 2017

BMC Musculoskelet Disord

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BackgroundRheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development of atherosclerosis. Moreover, post-translational modifications such as citrullination and carbamylation have been linked to inflammation and atherosclerosis. Anti-carbamylated proteins antibodies (anti-CarP) are a new subset of autoantibodies identified in RA patients. This study aimed to investigate a possible association between anti-CarP and subclinical atherosclerosis in RA patients.MethodsWe enrolled RA patients and normal healthy controls (NHS) without known cardiovascular risk factors or heart disease. Cardiovascular risk was assessed using the Modified Systemic Coronary Risk Evaluation (mSCORE). Anti-CarP were investigated by a solid phase “home-made” ELISA. Anti-citrullinated protein antibodies (ACPA) and Rheumatoid Factor (RF) were investigated by ELISA assays. Subclinical atherosclerosis was evaluated by brachial artery Flow-Mediated Dilatation (FMD) and Carotid Intima-Media Thickness (c-IMT) while arterial stiffness by Ankle-Brachial Index (ABI) and Cardio-Ankle Vascular Index (CAVI).ResultsWe enrolled 50 RA patients (34 F and 16 M, mean age 58.4 ± 13.1 years, mean disease duration 127 ± 96.7 months) and 30 age and sex matched NHS. According to the mSCORE, 58% of patients had a low risk, 32% a moderate and 8% a high risk for cardiovascular disease. FMD was significantly lower in RA patients than in NHS (5.6 ± 3.2 vs 10.7 ± 8.1%; p < 0.004) and CAVIs significantly higher in a RA patients compared to NHS (left CAVI 8.9 ± 1.7 vs 8.1 ± 1.5; p < 0.04 for and right CAVI 8.8 ± 1.6 vs 8.0 ± 1.4; p < 0.04 for the). ABI and c-IMT did not differ between the two populations. The multivariate regression analysis showed a significant association of anti-CarP antibodies with FMD, left and right CAVI and both c-IMT (r = 1.6 and p = 0.05; r = 1.7 and p = 0.04; r = 2.9 and p = 0.05; r = 1.5 and p = 0.03; r = 1.1 and p = 0.03 respectively).ConclusionsThis study confirms that RA patients, without evidence of cardiovascular disease or traditional risk factors, have an impaired endothelial function. Moreover, we found an association with anti-CarP antibodies suggesting a possible contribution of these autoantibodies to endothelial dysfunction, the earliest stage of atherosclerosis. Besides ultrasound assessment, anti-CarP should be assessed in RA patients and considered an additional cardiovascular risk factor.

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Section: Discussionsupporting

confidence: 93%

“…Moreover, the study confirms an association between ACPA and cIMT in accordance with previous findings [26, 27]. …”

Section: Discussionsupporting

confidence: 92%

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

Pecani

Ciciarello

Colasanti

et al. 2017

BMC Musculoskelet Disord

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“…also reported that CIMT levels were higher in RA patients than in their control group. In yet another study Vázquez‐Del Mercado et al . demonstrated that CIMT levels were higher in RA patients than in their control group and that it showed a correlation with DAS‐28, a score used to assess the disease's activity.…”

Section: Discussionmentioning

confidence: 99%

“…Free oxygen radicals, released by the systemic inflammation process, have an important role in the progression of RA . A systemic inflammation process has direct effects on vascular, peripheral tissue and organs and this leads to endothelial damage, dysfunction and oxidative changes, all of which help the development of atherosclerosis .…”

Section: Discussionmentioning

confidence: 99%

The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritis

et al. 2016

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“…This report is part of a larger project whose main objective is to assess predictors and evolution of CVD in RA patients. [ 9 , 10 ]…”

Section: Methodsmentioning

confidence: 99%

Disease duration of rheumatoid arthritis is a predictor of vascular stiffness

Mercado¹,

Gómez-Bañuelos²,

Chavarria-Ávila³

et al. 2017

Medicine

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The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities.Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Arterial stiffness was measured as cfPWV by noninvasive tonometry. A multivariate regression model was used to analyze the contribution of RA disease duration and age on cfPWV. cfPWV was positively correlated with age (r = 0.450, P < .001), RA disease duration (r = 0.340, P < .001), total cholesterol (r = 0.312, P = .002), and low density lipoprotein (LDL-c) cholesterol (r = 0.268, P = .012). Patients with a RA disease duration ≥10 years exhibited significantly increased cfPWV compared with patients with disease duration <2 years (8.4 ± 1.8 vs 7.0 ± 0.8) and ≥2 to <10 years (8.4 ± 1.8 vs 7.8 ± 1.3), respectively. Age, RA disease duration, and triglycerides were predictors of cfPWV in multivariate analyses. According to the β-coefficients, each year of disease duration (β = 0.072) had a greater impact on cfPWV than age (β = 0.054).Each year of life with RA contributes to a higher rate of vascular aging or stiffening than a year of life without RA. The cumulative damage provided by RA was most pronounced in patients with disease duration ≥10 years.

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Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

Cited by 34 publications

References 48 publications

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritis

Disease duration of rheumatoid arthritis is a predictor of vascular stiffness

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