Serum levels of anti‐streptolysin O antibodies: their role in evaluating rheumatic diseases

Ben‐Chetrit, Eli; Moses, Allon E.; Agmon‐Levin, Nancy; Block, Colin; Ben-Chétrit, Eldad

doi:10.1111/j.1756-185x.2011.01668.x

Cited by 16 publications

(16 citation statements)

References 15 publications

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“…The results were similar to the study by Ben-Chetritand alon a population of 28 subjects 13.8% of those under 18 had a history of angina, pharyngitis or even tonsillectomy and had a significant positive ASLO in hospitalized patients (33%) with highertiter rate compared to healthy controls (8%) [12]. According to the literature, 20% of group A streptococci do not produce streptolysin O.…”

Section: Discussionsupporting

confidence: 88%

Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar

Randriamahazo¹,

Ramihajamanana²,

Raherinaivo³

et al. 2019

IJI

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Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It's important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.

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Section: Discussionsupporting

confidence: 88%

Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar

Randriamahazo¹,

Ramihajamanana²,

Raherinaivo³

et al. 2019

IJI

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“…It should also be considered that etanercept is also affecting other body organs: For example, clinical studies in rheumatoid arthritis have indicated that etanercept -prescribed because of its anti-inflammatory activity-, can increase the risk of developing inflammatory bowel disease, lung infections, and pancytopenia ( Thavaranjah et al, 2009 ; Santana et al, 2012 ; O’Toole et al, 2016 ), but these side effects of etanercept are not frequently reported and the medication is generally well tolerated.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

et al. 2018

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Depression is a serious psychiatric disorder frequently comorbid with autoimmune disorders. Previous work in our lab has demonstrated that repeated corticosterone (CORT) injections in rats reliably increase depressive-like behavior, impair hippocampal-dependent memory, reduce the number and complexity of adult-generated neurons in the dentate gyrus, decrease hippocampal reelin expression, and alter markers of GABAergic function. We hypothesized that peripheral injections of the TNF-α inhibitor etanercept could exert antidepressant effects through a restoration of many of these neurobiological changes. To test this hypothesis, we examined the effect of repeated CORT injections and concurrent injections of etanercept on measures of object-location and object-in-place memory, forced-swim test behavior, hippocampal neurogenesis, and reelin and GABA β2/3 immunohistochemistry. CORT increased immobility behavior in the forced swim test and impaired both object-location and object-in-place memory, and these effects were reversed by etanercept. CORT also decreased both the number and complexity of adult-generated neurons, but etanercept restored these measures back to control levels. Finally, CORT decreased the number of reelin and GABA β2/3-ir cells within the subgranular zone of the dentate gyrus, and etanercept restored these to control levels. These novel results demonstrate that peripheral etanercept has antidepressant effects that are accompanied by a restoration of cognitive function, hippocampal neurogenesis, and GABAergic plasticity, and suggest that a normalization of reelin expression in the dentate gyrus could be a key component underlying these novel antidepressant effects.

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“…In a significant number of cases, the initial infection is subclinical 5. Throat cultures taken at the time of presentation with rheumatic fever or nephritis may be negative because of clearance of GAS by the host immune system during the latent period5 or due to previous antibiotic treatment 6. Interpretation of throat cultures at the time of presentation with a possible poststreptococcal complication is further confounded because a swab positive for GAS may represent asymptomatic carriage and not infection.…”

Section: Introductionmentioning

confidence: 99%

How to use antistreptolysin O titre

Sen

Ramanan

2014

Arch Dis Child Educ Pract Ed

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Group A streptococcus (GAS) is the cause of a wide range of acute suppurative and, following a latent period, non-suppurative diseases such as rheumatic fever and poststreptococcal glomerulonephritis. Diagnosis of the latter group requires evidence of preceding GAS infection. The bacteria produce a range of extracellular antigens, including streptolysin O, which induce an antibody response in the host. A rise in antistreptolysin O titre (ASOT) is indicative of preceding GAS infection. In clinical practice, often only a single ASOT measurement is available and its timing in relation to a possible GAS infection is unknown. Interpretation of the result in this context is liable to misdiagnosis. In order to optimise diagnosis of preceding GAS infection, at least two sequential ASOT measurements, together with simultaneous assay for anti-DNase B, a second antistreptococcal antibody, is recommended.

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Serum levels of anti‐streptolysin O antibodies: their role in evaluating rheumatic diseases

Abstract: Elevated ASO titers can be found in various clinical conditions other than the typical post-streptococcal associated diseases. In these cases it is not necessarily accompanied by positive culture and does not correlate with inflammatory parameters.

Cited by 16 publications

References 15 publications

Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar

Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

How to use antistreptolysin O titre

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