Serum levels of adiponectin differentiate generalized lipodystrophies from anorexia nervosa

Ceccarini, G.; Pelosini, C.; Paoli, M.; Tyutyusheva, N.; Magno, S.; Gilio, D.; Palladino, L.; Sessa, M. R.; Bertelloni, S.; Santini, F.

doi:10.1007/s40618-024-02308-3

Cited by 2 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In LDs, the inadequate subcutaneous fat storage is also associated with impaired adipokine secretion. The decrease in leptin and adiponectin has been extensively described in these disorders [7,27], and depending on fat loss, lower levels of adipokines were found in patients with generalized LDs (CGL and AGL) compared to partial FPLD and APL [6]. Contrastingly, in this study, we found that SIRT1 levels were substantially homogeneous regardless of the heterogeneity of fat levels in different LD subtypes, and thus no correlation with the amount of fat mass was evident.…”

Section: Discussioncontrasting

confidence: 75%

See 1 more Smart Citation

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Salvatori,

Magno,

Ceccarini

et al. 2024

IJMS

View full text Add to dashboard Cite

Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokine profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone deacetylases linked to fat metabolism. SIRT1 plays a critical role in metabolic health by deacetylating target proteins in tissue types including liver, muscle, and adipose. Circulating SIRT1 levels have been found to be reduced in obesity and increased in anorexia nervosa and patients experiencing weight loss. We evaluated circulating SIRT1 levels in relation to fat levels in 32 lipodystrophic patients affected by congenital or acquired LDs compared to non-LD subjects (24 with anorexia nervosa, 22 normal weight, and 24 with obesity). SIRT1 serum levels were higher in LDs than normal weight subjects (mean ± SEM 4.18 ± 0.48 vs. 2.59 ± 0.20 ng/mL) and subjects with obesity (1.7 ± 0.39 ng/mL), whereas they were close to those measured in anorexia nervosa (3.44 ± 0.46 ng/mL). Our findings show that within the LD group, there was no relationship between SIRT1 levels and the amount of body fat. The mechanisms responsible for secretion and regulation of SIRT1 in LD deserve further investigation.

show abstract

Section: Discussioncontrasting

confidence: 75%

“…Indeed, leptin is extremely low in subjects with reduced amounts of SAT, such as patients with CGL and AGL [5,6], and severe hyperphagia occurs because of leptin deficiency. Serum concentrations of adiponectin are also reduced in LDs and correlate with the extent of fat loss [6,7].…”

Section: Introductionmentioning

confidence: 99%

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Salvatori,

Magno,

Ceccarini

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Salvatori,

Ceccarini,

Magno

et al. 2024

Preprint

View full text Add to dashboard Cite

Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokines profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone-deacetylases linked to fat metabolism. SIRT1 plays a critical role in metabolic health by deacetylating target proteins in tissues including liver, muscle and adipose tissue. Circulating SIRT1 levels have been found to be reduced in obesity while increased in anorexia nervosa and in patients experiencing weight loss. We evaluated circulating SIRT1 levels in relation to fat amount in 32 lipodystrophic patients affected by congenital or acquired LDs compared to non-LD subjects (24 with anorexia nervosa, 22 normal weight and 24 with obe-sity). SIRT1 serum levels were higher in LDs as compared with normal weight subjects (mean ± SEM: 4.17 ± 0.48 vs. 2.59 ± 0.20 ng/mL) or subjects with obesity (1.7 ± 0.39 ng/mL), whereas they were close to those measured in anorexia nervosa (3.44 ± 0.46 ng/mL). Our findings show that within the LD group there was no relationship between SIRT1 levels and the amount of body fat. The mechanisms responsible for secretion and regulation of SIRT1 in LD deserve further investi-gation.

show abstract

Serum levels of adiponectin differentiate generalized lipodystrophies from anorexia nervosa

Cited by 2 publications

References 34 publications

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Contact Info

Product

Resources

About