Serum levels of adipocytokines in psoriasis patients receiving tumor necrosis factor‐α inhibitors: results of a retrospective analysis

Abstract

Patients with psoriasis show an imbalance between pro- and anti-inflammatory adipocytokines, which is reduced but not normalized after administration of TNF-α inhibitors for 24 weeks. This partial rebalancing seems to be mainly related to a reduction in proinflammatory adipocytokines, rather than an increase in anti-inflammatory adipocytokines.

Non-alcoholic fatty liver disease and psoriasis: So far, so near

“…About the possible biologics' action on adipocytokines' levels, Shibata et al [115] demonstrated an increased in adiponectin and IL-6 level after infliximab treatment. We have recently demonstrated that Adalimumab and Etanercept could be able to rebalance, but not normalize, adipocytokines' levels, mainly related to a reduction of pro-inflammatory ones rather than an increase of adiponectin [62] .…”

“…A higher risk of developing insulin resistance and of MetS components is detected in patients affected by central obesity than patients with excess of subcutaneous fat [59][60][61] . The energy storage, the endocrine role and the partecipation in the immune system are three important actions of the VAT [62] . Thus, excess adipose tissue results in an unbalance between pro-and anti-inflammatory cytokines and the increased inflammatory stimuli is responsible for the starting of the persistent low-grade inflammation [4,58,59] .…”

“…Furthermore, they play a crucial role in the pathogenesis of metabolic syndrome. Among adipocytokines, TNF-a, IL-6, leptin, visfatin, resistin appear to exert a pro-inflammatory effect, whereas adiponectin has anti-inflammatory properties [58,59,62] . The pathogenesis of both psoriasis and NAFLD is strictly dependent on the above cytokines [63] .…”

Obesity and Psoriasis: Can Bariatric Surgery Trigger Psoriasis?

“…Serum levels of TNF-α, IL-6, leptin, and resistin were found significantly higher (P <0.05) and serum adiponectin levels were significantly lower in patients with psoriasis than in controls (P<0.0001). Further, serum leptin level in men and women with psoriasis correlated positively with obesity (P<0.05) and was the only adipokines significantly decreased after TNF-α inhibitors treatment (P=0.0003) [17].…”

“…It was suggested that these cytokines can inhibit the synthesis of adiponectin (an anti-inflammatory adipokine) by the subcutaneous and visceral adipose tissue and can trigger psoriasis, metabolic syndrome and cardiovascular diseases [8]. In contrast, psoriasis patients found to have higher risks of incident obesity (HR 1.18; 95% CI 1.14- Metabolically, both psoriasis and obesity are associated with hypoadiponectinemia and hyperleptinemia, at statistical significance [17,18]. Adiponectin acts as anti-inflammatory adipokines involves in the regulation of numerous physiological functions and immune response.…”