Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability

Silvello, Daiane; Narvaes, Luciane Barreneche; Albuquerque, Luciano Cabral; Forgiarini, Luiz Felipe; Meurer, Luíse; Martinelli, Nidiane Carla; Andrades, Michael Éverton; Clausell, Nadine Oliveira; Santos, Kátia Gonçalves dos; Rohde, Luís Eduardo Paim

doi:10.3109/1354750x.2013.866165

Cited by 53 publications

(43 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Это подтверждает их роль в дестабилизации АСБ сонных артерий и использование в качестве маркера прогнозирования динамики каротидного атеросклероза. Аналогичные данные были получены и другими авторами [4,9,13,17,19,21]. Кроме того, обнаружена значимая положительная корреляция уровней ММП-9 и ТИМП-1 со степенью стеноза сонных артерий, что согласуется мнениями ряда исследователей [4,7,10,15,16].…”

Section: Discussionunclassified

See 1 more Smart Citation

Associations of Biomarkers of Atherosclerotic Plaques Instability (MMP-9, TIMP-1) and Zinc Levels in Carotid Atherosclerosis

Costello

Lipcey²,

Olive³

2015

European Journal of Medicine. Series B

View full text Add to dashboard Cite

The levels of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor (TIMP-1) in serum, and the concentration of Zn in the serum, hair and carotid atherosclerotic plaques were examined. The relationships zinc-dependent endopeptidases as biomarkers instability of atherosclerotic plaques and zinc in patients with carotid atherosclerosis were studied. The results contribute to the selection of patients at high risk for cardiovascular events.Keywords: matrix metalloproteinase -9; tissue inhibitor of metalloproteinase-1; zinc; unstable atherosclerotic plaque. ВведениеНестабильность атеросклеротической бляшки (АСБ) является главной причиной инфаркта миокарда (ИМ) и инсульта [14]. Вместе с тем, склонные к разрыву АСБ сонной артерии являются независимыми факторами риска, наличия коронарного атеросклероза и развитие ИМ [1]. Уязвимость АСБ зависит от многих факторов таких, как дисфункция эндотелия, воспалительные клетки, продукция цитокинов, содержание гладкомышечной клетки и гибель клеток (апоптоз) [11].Ранимые АСБ имеет тонкую, воспаленную и бедным коллагеновым волокнам фиброзную покрышку, которые содержат повышенные уровни матриксных металлопротеиназ (ММП) [14]. Существует дисбаланс между ММП и тканевыми ингибиторами (ТИМП) в нестабильных АСБ сонных артерий, что определяет уровни этих маркеров в плазме крови [16].Известно, что ММП относятся к семейству цинк-зависимых эндопептидаз, ответственного за расщепление и восстановление внеклеточного матрикса соединительной ткани. Установлена связь уровня ММП-9 в сыворотке с нестабильностью каротидного атеросклероза [9,13,17,21]. ММП в своѐм каталитическом домене содержит ионы цинка (Zn2+) [22].

show abstract

Section: Discussionunclassified

“…Установлена связь уровня ММП-9 в сыворотке с нестабильностью каротидного атеросклероза [9,13,17,21]. ММП в своѐм каталитическом домене содержит ионы цинка (Zn2+) [22].…”

Section: Introductionunclassified

Associations of Biomarkers of Atherosclerotic Plaques Instability (MMP-9, TIMP-1) and Zinc Levels in Carotid Atherosclerosis

Costello

Lipcey²,

Olive³

2015

European Journal of Medicine. Series B

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of atherosclerosis is very complex, and several genes and their products have so far been implicated in the pathogenesis of atherosclerosis [5][6][7][8]. A very interesting candidate gene system is the matrix metalloproteinase (MMP) family.…”

Section: Introductionmentioning

confidence: 99%

“…A very interesting candidate gene system is the matrix metalloproteinase (MMP) family. The MMPs are proteolytic enzymes that degrade the extracellular matrix, leading to connective tissue remodelling during normal and pathological vascular remodelling [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus

Pleskovič

Letonja

Vujkovac

et al. 2017

Vasa

View full text Add to dashboard Cite

Summary: Background:The study was designed to test the possible association between either polymorphisms of the matrix metalloproteinase-9 (MMP-9) gene (rs17576, rs3918242) or the MMP-3 5A/6A gene polymorphism (rs3025058) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The second aim of the study was to demonstrate an association between either the rs17576, rs3918242 or rs3025058 and subclinical markers of coronary artery disease in the same subset of patients with T2DM. Patients and methods: A total of 595 subjects with T2DM and 200 subjects without T2DM (control group) were enrolled in the prospective study. Subclinical markers of carotid atherosclerosis were assessed ultrasonographically. Additionally, in a subset of subjects with T2DM a coronary computed tomography angiography (CCTA) was performed for diagnostic purposes. Genotyping of all three polymorphisms (rs17576, rs3918242, rs3025058) was performed with real-time PCR systems. Results: The comparison of atherosclerosis parameters was performed with regard to different genotypes of MMP-9 rs17576, rs3918242, and MMP-3 rs3025058 polymorphisms upon enrolment and during follow-up. In our study, we found an association between the MMP-3 rs3025058 and CIMT at the time of recruitment. Multiple linear regression analysis revealed the association of either the A-allele or the A-genotypes of the rs3025058 (MMP-3) with carotid intima media thickness (CIMT) progression in a 3.8-year follow-up. We demonstrated the effect of the rs3025058 on subclinical markers of coronary atherosclerosis (coronary calcium score, number of coronary arteries with more than 50 % stenosis, and presence of at least one vessel with more than 50 % stenosis). Conclusions: We found an association between the MMP-3 rs3025058 and subclinical markers of carotid (CIMT) and coronary atherosclerosis at the time of recruitment. Moreover, we demonstrated the effect of the MMP-3 rs3025058 on CIMT progression in the 3.8-year follow-up in patients with T2DM.

show abstract

“…Matrix metalloproteinases (MMPs) contribute to atherosclerotic lesion progression by involving in extracellular matrix degradation [1,2]. With the progress of disease, the over-expression of these enzymes lead to thinning of the plaque fibrous cap, resulting in plaque instability, rupture and thrombosis and thus development to acute ischemic in the clinical [3].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between MMP-9 and Infarct Related Artery Reflow in Acute STEMI Patients

Guo¹,

Chai²,

Liu³

et al. 2017

J Diabetes Metab

View full text Add to dashboard Cite

Objective: Atherosclerotic plaque rupture leading to coronary artery occlusion is the culprit event which underpins a majority of acute myocardial infarction, and Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix degradation and artificial balloon extrusion. Patients with ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture are at high risk for slow reflow, but the relationship between reflow and MMP-9 remains unclear, especially in the real world of local plaque rupture. We investigated the association between the levels of matrix metalloproteinase-9 (MMP-9) in infarct-related arterial infusion and the risk of slow reflow in STEMI patients following percutaneous coronary intervention (PCI). Methods: 65 eligible acute STEMI patients undergoing successful PCI were included in the current study. Blood samples were obtained from the extraction catheter placed distal to the lesion during PCI. Plasma MMP-9 levels were determined by immunoassay method. Results: Using multiple logistic regression analysis, MMP-9 levels (OR 0.881, CI 0.791-0.981; P=0.021) was found to be a significant risk factor of slow flow together with HSCORE (OR=0.085, CI 0.014-0.506; P=0.007). ROC curve with area under the curve (0.740) and 95% confidence interval (0.607-0.872) revealed that lesion MMP-9 changes had an predictive value for no reflow(P=0.002). Conclusions:The present study indicated that plasma MMP-9 levels in the culprit coronary artery was associated with slow flow in patients with ST-elevation MI following successful primary PCI.

show abstract

Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability

Abstract: MMP-9 serum levels were consistently associated with markers of carotid atherosclerosis and lesion vulnerability, whereas specific MMP genotypes were not.

Cited by 53 publications

References 32 publications

Associations of Biomarkers of Atherosclerotic Plaques Instability (MMP-9, TIMP-1) and Zinc Levels in Carotid Atherosclerosis

Associations of Biomarkers of Atherosclerotic Plaques Instability (MMP-9, TIMP-1) and Zinc Levels in Carotid Atherosclerosis

Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus

The Relationship between MMP-9 and Infarct Related Artery Reflow in Acute STEMI Patients

Contact Info

Product

Resources

About