Serum levels and genetic variations of cytokines in two canine breeds (Ibizan hound and boxer) in the Mediterranean region, in terms of Leishmania infantum infection

Álvarez, Luis; Marín-García, Pablo Jesús; Llobat, Lola

doi:10.1016/j.cimid.2022.101908

Cited by 2 publications

(1 citation statement)

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“…The effect of canine breed has been observed in the seroprevalence of different pathogens, such as L. infantum [ 16 ], A. phagocytophilum [ 17 ], or E. canis [ 18 ]. In fact, susceptibility or resistance to different infections seems to be correlated with canine breed, with certain breeds being more susceptible, such as Boxers, Doberman Pinschers, English Cocker Spaniels, or German Shepherds [ 16 , 19 , 20 ], whereas others seem to be more resistant, such as the Ibizan hound or Beagles [ 20 , 21 , 22 ], depending on the pathogen. Other canine breeds, such as the Cirneco dell’Etna, phylogenetically close to the Ibizan hound [ 23 ] or the St. Bernard, phylogenetically close to Retrievers [ 24 ], have never been evaluated for any pathogen.…”

Section: Introductionmentioning

confidence: 99%

Effect of Breed on Hematological and Biochemical Parameters of Apparently Healthy Dogs Infected with Zoonotic Pathogens Endemic to the Mediterranean Basin

Amato,

Cavallo,

Marín-García

et al. 2024

Animals

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Dogs are considered the main reservoir of several zoonoses endemic to the Mediterranean Basin. In this study, a prevalence of infections and coinfections of canine vector-borne diseases was analyzed in apparently healthy dogs of different canine pure breeds in Sicily (Italy), where these diseases are endemic. The seroprevalence of Leishmania infantum, Ricketsia ricketsii, Anaplasma phagocytophilum, and Erlichia canis was assessed, as single and coinfections. Biochemical and hematological parameters were evaluated, and epidemiological factors, including sex, age, and canine breed, were recovered. The most frequent infection was L. infantum (45.61%), following R. ricketsii (36.84%), both as single, double, or triple coinfections. Coinfections change the biochemical and hematological parameters of the host, and canine breeds are related to the infection frequency and the parameters observed during infections. Changes in the complete blood count (CBC) and biochemical values also differ between canine breeds, with the Cirneco dell’Etna dogs infected with L. infantum being the animals presenting the most interesting results in our study. High values of RBC, hemoglobin, hematocrit, mean corpuscular hemoglobin (MCH), the albumin/globulin (A/G) ratio, and albumin and low levels of β-2 globulin and γ-globulin were found only in this canine breed, suggesting some resistance to infection in these dogs. Future studies about the immune response of this canine breed could be interesting to determine their possible resistance to zoonotic pathogens, such as L. infantum.

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