Serum level of soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1) is a biomarker of synovitis in rheumatoid arthritis

Gorlier, Clémence; Gottenberg, Jacques-Éric; Laurans, Ludivine; Simon, Tabassome; Ait‐Oufella, Hafid; Sellam, Jérémie

doi:10.1111/1756-185x.13656

Cited by 8 publications

(8 citation statements)

References 7 publications

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“…Furthermore, a positive correlation between TREM-1 and PGLYRP1 serum levels and clinical disease activity were observed in RA patients. Earlier studies have also found elevated TREM-1 levels in synovial fluid, plasma and serum of RA patients compared to controls with some of them reporting significant associations to clinical and laboratory parameters of RA disease activity, although the relationship of TREM-1 to radiological damages or the functional capacity has not been discussed [12][13][14]16 .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, treatment-naïve RA patients were shown to bare higher serum levels of TREM-1 compared to RA patients treated by disease-modifying anti-rheumatic drugs (DMARDs) 12 . Positive correlations were also identified between serum TREM-1 levels and RA disease activity (28-joint disease activity score-DAS-28), C-reactive protein (CRP) and levels of anti-citrullinated protein antibodies (ACPA), a hallmark of RA pathogenesis 12,16 . Similarly, plasma TREM-1 levels were also positively correlated with DAS-28, CRP, erythrocyte sedimentation rate (ESR), white blood cell counts, neutrophil counts, and tumor necrosis factor-α (TNF-α) levels 15 .Peptidoglycan recognition protein 1 (PGLYRP1) is an antimicrobial protein present in polymorphonuclear leukocyte granules and secreted upon degranulation to counteract microbial infections.…”

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confidence: 99%

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Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

İnanç

Mumcu

Can

et al. 2021

Sci Rep

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The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

İnanç

Mumcu

Can

et al. 2021

Sci Rep

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“…For the therapeutic drug development, targeted photodynamic therapy (tPDT) using the anti-FAP antibody 28H1 coupled to the photosensitizer IRDye700DX moderately delayed the collagen-induced arthritis development in mice [ 42 ]. Meanwhile, TREM-1 has also been identified as a biomarker of synovitis in RA [ 43 ] and predicting the therapeutic response to methotrexate in RA [ 44 ]. Inhibiting the expression of TREM-1 could suppress the chondrocyte injury induce by IL-1β in vitro [ 45 ], and ameliorate collagen-induced arthritis and protect bone and cartilage damage in vivo [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue

Zheng

2020

IJMS

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Arthritis is the leading cause of disability among adults, while osteoarthritis (OA) is the most common form of arthritis that results in cartilage loss. However, accumulating evidence suggests that the protective hyaline cartilage should not be the sole focus of OA treatment. Particularly, synovium also plays essential roles in OA’s initiation and progression and warrants serious consideration when battling against OA. Thus, biomarkers with similar OA-responsive expressions in cartilage and synovium should be the potential targets for OA treatment. On the other hand, molecules with a distinguished response during OA in cartilage and synovium should be ruled out as OA therapeutic(s) to avoid controversial effects in different tissues. Here, to pave the path for developing a new generation of OA therapeutics, two published transcriptome datasets of knee articular cartilage and synovium were analyzed in-depth. Genes with statistically significantly different expression in OA and healthy cartilage were compared with those in the synovium. Thirty-five genes with similar OA-responsive expression in both tissues were identified while recognizing three genes with opposite OA-responsive alteration trends in cartilage and synovium. These genes were clustered based on the currently available knowledge, and the potential impacts of these clusters in OA were explored.

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“…Elevated levels of serum sTREM-1 were shown to be increased in systemic inflammatory response and sepsis, with a better prognosis as opposed to non survivors [31,32]. Serum sTREM-1 was found to be a new interesting marker for Rheumatoid Arthritis disease activity, not only reflecting systemic inflammation but also clinical joint inflammation, suggesting a specific role of sTREM-1 in Rheumatoid Arthritis pathophysiology [33]. Serum levels of sTREM-1 were also found to have prognostic role in oncology patients.…”

Section: Discussionmentioning

confidence: 99%

sTREM-1 assessment as a diagnostic biomarker for suspected acute appendicitis in children

Klein

Kohn

Klin

et al. 2019

Preprint

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Background The typical history of acute appendicitis is observed in less than 60% of cases. Therefore, searching for a surrogate marker is mandatory. Our goal was to determine whether the soluble triggering receptor expressed on myeloid cells (sTREM-1) is an efficient biomarker for acute appendicitis. Methods sTREM-1 serum levels were measured in addition to carrying out routine diagnostic tests (urine dipstick, complete blood count and C- reactive protein) in children admitted to the Emergency Department with suspected appendicitis. Statistical analysis was performed in order to examine whether sTREM-1 was a significant predictor of appendicitis. Results Fifty three of 134 children enrolled in the study were diagnosed with appendicitis. There was no significant difference in serum sTREM-1 levels (p=0.111) between children with or without appendicitis. Leukocytes, neutrophils and CRP were significantly elevated in the appendicitis group (p<0.001). The appendix diameter was significantly larger and the Alvarado score significantly higher in the appendicitis group (p<0.001). Conclusion serum sTREM-1 is not a good marker for acute appendicitis. Customary tests in addition to a proper patient history and physical examination are still the most effective methods to diagnose acute appendicitis.

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Serum level of soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1) is a biomarker of synovitis in rheumatoid arthritis

Cited by 8 publications

References 7 publications

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue

sTREM-1 assessment as a diagnostic biomarker for suspected acute appendicitis in children

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