Serum Level of Soluble Intercellular Adhesion Molecule-1 Correlates with Pulmonary Arterial Pressure in Children with Congenital Heart Disease

Sungprem, Kanrawee; Khongphatthanayothin, Apichai; Kiettisanpipop, Patchara; Chotivitayatarakorn, Pairoj; Poovorawan, Yong; Lertsapcharoen, Pornthep

doi:10.1007/s00246-008-9374-1

Cited by 19 publications

(18 citation statements)

References 19 publications

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“…Recently, Bakouboula et al (2) found that there was a positive correlation between endothelial stimulation, mean PAP, and sVCAM-1 in adult patients. Another study of children with congenital heart diseases showed that sICAM-1 levels were significantly higher in PAH group (8). Like these studies, we also found a strong association between mean PAP and preoperative sICAM-1 level.…”

Section: Discussionsupporting

confidence: 86%

“…Cardiac surgery is also associated with increased plasma adhesion molecule levels (7). Recently; increased sICAM-1 levels have been reported in patients with L-R shunt with PAH (8). Cardiac surgery of the patients with PAH carries increased risk of mortality and morbidity which can be reduced by using prognostic markers of endothelial activation and there is no study to investigate prognostic value of ICAM and VCAM in this group of patients.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of sICAM-1 and sVCAM-1 Molecules for cardiac surgery in pediatric patients with pulmonary hypertension

Yıldırım¹,

Güzelmeriç²,

Oner³

et al. 2014

Anadolu Kardiyol Derg

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Objective: To investigate preoperative and postoperative blood levels of soluble intercellular and vascular cell adhesion molecules (sICAM-1, sVCAM-1) in patients with and without pulmonary hypertension (PAH) due to congenital heart disease and left to right (L-R) shunt and to determine whether these molecules can be used as reliable prognostic markers of endothelial activity to predict surgical outcomes. Methods: In this observational prospective cohort study; 42 patients, operated for L-R shunt were divided into three groups. Group 1: L-R shunt without PAH, Group 2: L-R shunt with PAH, Group 3: L-R shunt with PAH and postoperative low cardiac output syndrome (LCOS). Their sICAM-1 and sVCAM-1 levels were measured preoperatively (sICAM-0, sVCAM-0) and on the first (sICAM-1, sVCAM-1) and fifth postoperative days (sICAM-2, sVCAM-2).ROC curve for various cut-off levels of sICAM-0, sVCAM-0 in differentiating PAH patients with and without LCOS. Results: In Group 3, sICAM-0 and sVCAM-2 levels were higher than Group 1 and 2. The ROC curve demonstrated a significant association between sICAM-0 in patients with L-R shunt and PAH (Group 2 and 3) and the development of LCOS (area under the curve: 0.98, p<0.01 and 0.97, p<0.01, respectively). At a sICAM-0 concentration >359 ng/mL, there was a sensitivity of 90% and specificity of 95% for identification of LCOS in patients with L-R shunt and PAH (AUC: 0.98, 95% CI: 0.95-1.02, p<0.01). Conclusion: High preoperative sICAM-1 molecule may be used to predict postoperative dichotomous outcome in patients with PAH associated with L-R shunt. (Anadolu Kardiyol Derg 2014; 14: 274-9)

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Prognostic significance of sICAM-1 and sVCAM-1 Molecules for cardiac surgery in pediatric patients with pulmonary hypertension

Yıldırım¹,

Güzelmeriç²,

Oner³

et al. 2014

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

show abstract

“…The ICAM-1 levels were higher in patients with a mean PAP of >25 mmHg, and mean PAP was the strongest independent marker of ICAM-1 levels, according to the multiple regression model. 10 We too found that ICAM-1 level correlated rather strongly with systolic and mean PAP ( Fig. 3 and Table III).…”

mentioning

confidence: 55%

“…5,6 In the medical literature, 7-9 elevated serum concentrations of adhesion molecules have been detected in several diseases, such as diabetes mellitus, coronary heart disease, atherosclerosis, and rheumatoid arthritis. Sungprem and colleagues 10 showed that serum ICAM-1 level was increased in patients with PAH. …”

mentioning

confidence: 98%

Serum Levels of Soluble ICAM-1 in Children with Pulmonary Artery Hypertension

Oğuz¹,

Aydın²,

Sanli³

et al. 2014

Texas Heart Institute Journal

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This prospective cross-sectional study attempted to determine both the usefulness of the serum intercellular adhesion molecule-1 (ICAM-1) as a biomarker for pulmonary artery hypertension secondary to congenital heart disease and the nature of this marker's association with catheter angiographic findings.Our C ongenital heart disease (CHD) is the most common congenital malformation: the prevalence of moderate and severe forms of CHD is about 6 in 1,000 live births, or 19 in 1,000 live births if potentially serious cases of bicuspid aortic valve are included.1 Pulmonary artery hypertension (PAH) is a frequent complication of CHD, particularly in patients who have left-to-right shunts.2 Pulmonary artery hypertension has been defined as an increase in mean pulmonary artery pressure (PAP) of ≥25 mmHg at rest, as evaluated by right-sided heart catheterization. 3Pulmonary artery hypertension has a multifactorial pathogenesis that involves various biochemical pathways and cell types. The increase in pulmonary vascular resistance is related to different mechanisms, including vasoconstriction, proliferative and obstructive remodeling of the pulmonary vessel wall, inflammation, and thrombosis. Persistent exposure of the pulmonary vasculature to increased blood flow and pressure can result in endothelial dysfunction and endothelial damage.2 After such damage, endothelial cells produce an array of cytokines and growth factors and promote immune cells to adhere to and migrate through the vessel wall into the extravascular space. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are expressed on endothelial cells. When overexpressed on the activated endothelial layer, VCAM-1 and ICAM-1 undergo shedding, and their soluble forms (detectable in serum) are considered to be markers of endothelial cell activity or injury. 5,6 In the medical literature, 7-9 elevated serum concentrations of adhesion molecules have been detected in several diseases, such as diabetes mellitus, coronary heart disease, atherosclerosis, and rheumatoid arthritis. Sungprem and colleagues 10 showed that serum ICAM-1 level was increased in patients with PAH.

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“…Burke et al demonstrated increased expression levels of the adhesion molecules ICAM-1 and VCAM-1 in the pulmonary arteries of chronically hypoxic rats (11). Furthermore, elevated levels of these adhesion molecules have been demonstrated in children with congenital heart disease and PH (40), whereas amelioration of chronic hypoxiainduced PH was associated with decreased ICAM-1 expression (41). Although few published reports have demonstrated that CXCR7 directly modulates the expression of these adhesion proteins (20), the involvement of CXCR7 in cell adhesion was shown in several recent studies.…”

Section: Discussionmentioning

confidence: 99%

Antagonism of CXCR7 attenuates chronic hypoxia–induced pulmonary hypertension

et al. 2012

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Serum Level of Soluble Intercellular Adhesion Molecule-1 Correlates with Pulmonary Arterial Pressure in Children with Congenital Heart Disease

Abstract: Children with CHD and pulmonary hypertension had a trend toward elevated sICAM-1 compared with CHD children who had no pulmonary hypertension. A linear correlation was found between mean pulmonary arterial pressure and sICAM-1 level.

Cited by 19 publications

References 19 publications

Prognostic significance of sICAM-1 and sVCAM-1 Molecules for cardiac surgery in pediatric patients with pulmonary hypertension

Prognostic significance of sICAM-1 and sVCAM-1 Molecules for cardiac surgery in pediatric patients with pulmonary hypertension

Serum Levels of Soluble ICAM-1 in Children with Pulmonary Artery Hypertension

Antagonism of CXCR7 attenuates chronic hypoxia–induced pulmonary hypertension

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