Serum level of sex steroid hormone is associated with diversity and profiles of human gut microbiome

Shin, Ji-Hee; Park, Younghee; Sim, Min Sub; Kim, Seong-Ah; Joung, Hyojee; Shin, Dong‐Mi

doi:10.1016/j.resmic.2019.03.003

Cited by 200 publications

(189 citation statements)

References 50 publications

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“…A mouse model study showed that after inoculating germ-free C57BL/6 J mice with fecal bacteria from a man with short-term vegetarian and inulin-supplemented diet, the abundance of Dorea and Clostridium were over-represented in females [ 22 ]. Furthermore, Shin JH [ 23 ] reported that the abundance of Dorea correlated significantly with the level of testosterone in males, a finding consistent with the results of our study. As known that the two bacteria Parabacteroides and Adlercreutzia could metabolize phytoestrogens with generation of secondary molecules such as secoisolariciresinol, enterolactone, and equol [ 24 ], we speculate that the two bacteria might be affected by sex hormones.…”

Section: Discussionsupporting

confidence: 92%

Gut microbiota: effect of pubertal status

et al. 2020

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Background The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Result The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone. Conclusions This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.

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Section: Discussionsupporting

confidence: 92%

Gut microbiota: effect of pubertal status

et al. 2020

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“…A mouse model study showed that after inoculating germ-free C57BL/6J mice with fecal bacteria from a man with short-term vegetarian and inulin-supplemented diet, the abundance of Dorea and Clostridium were over-represented in females (25). Furthermore, Shin JH (26) reported that the abundance of Dorea correlated signi cantly with the level of testosterone in males, a nding consistent with the results of our study. As known that the two bacteria Parabacteroides and Adlercreutzia could metabolize phytoestrogens with generation of secondary molecules such as secoisolariciresinol, enterolactone, and equol (27), we speculate that the two bacteria might be affected by sex hormones.…”

Section: Discussionsupporting

confidence: 90%

Gut Microbiota: Effect of Pubertal Status

Yuan

Chen

Zhang

et al. 2020

Preprint

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Background: The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Methods: The fecal microbiome was determined in 89 Chinese subjects aged 5-15 years. Subjects were grouped as non-pubertal (n=42) or pubertal (n=47) according to Tanner stages. Gut colonization patterns were determined by 16S rDNA microbiome profiling.Results: The subjects were divided into non-pubertal (n=42, male%: 66.7%) or pubertal groups (n=47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had significantly higher members of the genus Turicibacter and lower members of genus Sutterella than pubertal subjects. Of note, the proportion of genus Sutterella increased gradually with the pubertal status and independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone.Conclusion: This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.

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“…A mouse model study showed that after inoculating germ-free C57BL/6J mice with fecal bacteria from a man with short-term vegetarian and inulin-supplemented diet, the abundance of Dorea and Clostridium were over-represented in females (26). Furthermore, Shin JH (27) reported that the abundance of Dorea correlated signi cantly with the level of testosterone in males, a nding consistent with the results of our study. As known that the two bacteria Parabacteroides and Adlercreutzia could metabolize phytoestrogens with generation of secondary molecules such as secoisolariciresinol, enterolactone, and equol (28), we speculate that the two bacteria might be affected by sex hormones.…”

Section: Discussionsupporting

confidence: 90%

Gut Microbiota: Effect of Pubertal Status

Yuan

Chen

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Methods: The fecal microbiome was determined in 89 Chinese subjects aged 5-15 years. Subjects were grouped as non-pubertal (n=42) or pubertal (n=47) according to Tanner stages. Gut colonization patterns were determined by 16S rRNA microbiome profiling.Results: The subjects were divided into non-pubertal (n=42, male%: 66.7%) or pubertal groups (n=47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance were independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone.Conclusion: This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.

show abstract

Serum level of sex steroid hormone is associated with diversity and profiles of human gut microbiome

Cited by 200 publications

References 50 publications

Gut microbiota: effect of pubertal status

Gut microbiota: effect of pubertal status

Gut Microbiota: Effect of Pubertal Status

Gut Microbiota: Effect of Pubertal Status

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