Serum level of sCD163, a soluble receptor for hemoglobin, is influenced by cardiac surgery

Abstract

Serum level of sCD163 scavenger molecule for hemoglobin is elevated at the end of surgery and at the 1(st) postoperative day, being little influenced by cardiopulmonary bypass.

Impact of cardiac surgery on the expression of CD40, CD80, CD86 and HLA-DR on B cells and monocytes

“…Further details of the surgical techniques have been described in the previous articles. 21,22 No statistically significant differences were found among the groups of patients. BMI: body mass index; COPD: chronic obstructive pulmonary disease.…”

Expression of urokinase plasminogen activator receptor on monocytes and granulocytes is modulated by cardiac surgery

“…uPAR endocytosis may represent one form of the many anti-inflammatory mechanisms induced in cardiac surgery patients. Activation of anti-inflammatory mechanisms (such as IL-10 production and hemoglobin scavenger receptor upregulation 13,14 ) counterbalances the effect of the pro-inflammatory response induced by surgery. Sequestration of active plasmin protease from the cell surface down-modulates its overall pro-inflammatory activities.…”

Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation

“…While they are contributing to the development of the inflammatory response by sensing the danger patterns and secreting pro-inflammatory cytokines early during this process, macrophages/monocytes also exert anti-inflammatory functions late in inflammation 5 . This functional shift of monocytes/macrophages is accompanied by profound changes in the expression of immunoregulatory molecules such as scavenger receptor for hemoglobin CD163 on their membrane, with an apparent anti-inflammatory activity 6,7 Cell-to-cell interactions of myeloid cells (i.e. macrophages, neutrophils, and dendritic cells) recently have been identified.…”