Serum Level of IP-10 Increases Predictive Value of IL28B Polymorphisms for Spontaneous Clearance of Acute HCV Infection

Beinhardt, Sandra; Aberle, Judith H.; Straßer, Michael; Dulic-Lakovic, E; Maieron, A; Kreil, Anna; Rutter, Karoline; Staettermayer, A.F.; Datz, Christian; Scherzer, Thomas–Matthias; Straßl, Robert; Bischof, Martin; Stauber, Rudolf; Bodlaj, Gerd; Laferl, Hermann; Holzmann, Heidemarie; Steindl–Munda, Petra; Ferenci, Péter; Hofer, Harald

doi:10.1053/j.gastro.2011.09.039

Cited by 86 publications

(75 citation statements)

References 27 publications

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“…rs12979860 and rs8099917 are both associated with SVR and are in strong linkage disequilibrium (37,38). We selected the rs12979860 polymorphism because this polymorphism was reported to be more informative than rs8099917 in a cohort of patients with Caucasian ancestry (39). rs8099917 was analyzed by direct sequencing in 28 patients of the cohort as described in reference 40.…”

Section: Resultsmentioning

confidence: 99%

Reduction of MicroRNA 122 Expression in IFNL3 CT/TT Carriers and during Progression of Fibrosis in Patients with Chronic Hepatitis C

Estrabaud

Lapalus

Broët

et al. 2014

J Virol

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The microRNA miR-122 is highly expressed in the liver and stimulates hepatitis C virus (HCV) replication in vitro. IFNL3 (lambda-3 interferon gene) polymorphisms and the expression of miR-122 have been associated with sustained virological response (SVR) to treatment with pegylated interferon plus ribavirin in patients with chronic hepatitis C (CHC). We investigated, in vivo, the relationship between miR-122 expression, IFNL3 polymorphism, fibrosis, and response to PEG-IFN plus ribavirin. IMPORTANCEmiR-122 plays a crucial role during HCV infection. Moreover, it was reported that miR-122 binding within the HCV genome stimulates its replication. Moreover, miR-122 is highly expressed within hepatocytes, where it regulates many cellular pathways. A reduction of miR-122 expression has been suggested to be associated with responsiveness to IFN-based therapy in patients with chronic hepatitis C. Several independent genome-wide association studies reported a strong association between IFNL3 polymorphism and responsiveness to IFN-based therapy. We report here a strong association between the expression of miR-122 and IFNL3 polymorphism that is independent of the response to the treatment. Our data suggest that modification of miR-122 expression may play an important role in the molecular mechanism associated with IFNL3 polymorphism. Moreover, we report a reduction of miR-122 at more advanced stages of fibrosis in patients with chronic hepatitis C.

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Section: Resultsmentioning

confidence: 99%

Reduction of MicroRNA 122 Expression in IFNL3 CT/TT Carriers and during Progression of Fibrosis in Patients with Chronic Hepatitis C

Estrabaud

Lapalus

Broët

et al. 2014

J Virol

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“…Previous studies in CHC showed that patients with rs12979860 CC genotype had lower IP-10 levels [14,43]. Our data showed that there was no correlation between IL28B SNPs and IP-10 levels, but in patients with low viral load (HBV DNA ,5610…”

Section: Discussionmentioning

confidence: 45%

“…Furthermore, a recent study showed that patients with lower serum levels of interferon gamma-inducible protein 10 (IP-10) in combination with favorable IL28B genotypes had higher chance of spontaneous HCV clearance [14]. Whether IL28B polymorphisms have influence on host immune response to HBV infection is unknown.…”

Section: Introductionmentioning

confidence: 99%

417 IL28B POLYMORPHISM CORRELATES WITH ACTIVE HEPATITIS IN PATIENTS WITH HBeAg-NEGATIVE CHRONIC HEPATITIS B

Lee¹,

Lin²,

Huang³

et al. 2013

Journal of Hepatology

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“…The combination of serum IP-10 and rs12979860 significantly improved the prediction of SVR [111][112][113]. Serum IP-10 was particularly informative in rs12979860 CT carriers, in whom high serum IP-10 levels resulted in a 64% SVR compared to 24% in patients with low IP-10 [112].…”

Section: Host Factorsmentioning

confidence: 93%

Genomics and HCV infection: Progression of fibrosis and treatment response

Estrabaud

Vidaud

Marcellin

et al. 2012

Journal of Hepatology

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HCV infection is a global health problem that affects 170 million people worldwide. The severity of the disease varies from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma (HCC). Recently, the standard of care for genotype 1 patients has greatly improved with the addition of protease inhibitors (telaprevir or boceprevir) to pegylated interferon (PegIFN) and ribavirin (RBV). The prediction of fibrosis progression and the response to antiviral treatment are two major issues in the management of patients with chronic hepatitis C. Differential expression of mRNAs was first analyzed for both progression of fibrosis and treatment response. Specific polymorphisms, associated with either fibrosis or viral response, were identified thanks to major improvements in genome scanning technologies. Since 2009, several independent genome wide association studies (GWAS) have reported an association between genetic polymorphisms within the IL-28B promoter and both natural and treatment-induced clearance in genotype 1 infected patients. These different studies showed the strong association and the importance of IL-28B polymorphisms in the treatment response. Combining the different genetic factors could improve their predictive value and help identify patients at a high risk of progression of fibrosis as well as those with a lower chance of responding to treatment. The aim of this review was to discuss the genomic factors (mRNAs, miRNAs, and SNPs) and HCV infection with clinical implications for either progression of fibrosis or treatment response. Recent findings on the IL-28B polymorphism and its application in clinical practice will also be discussed.

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Serum Level of IP-10 Increases Predictive Value of IL28B Polymorphisms for Spontaneous Clearance of Acute HCV Infection

Cited by 86 publications

References 27 publications

Reduction of MicroRNA 122 Expression in IFNL3 CT/TT Carriers and during Progression of Fibrosis in Patients with Chronic Hepatitis C

Reduction of MicroRNA 122 Expression in IFNL3 CT/TT Carriers and during Progression of Fibrosis in Patients with Chronic Hepatitis C

417 IL28B POLYMORPHISM CORRELATES WITH ACTIVE HEPATITIS IN PATIENTS WITH HBeAg-NEGATIVE CHRONIC HEPATITIS B

Genomics and HCV infection: Progression of fibrosis and treatment response

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