Serum level of IL-6 in liver cirrhosis patients

Rey, Imelda; Effendi-Ys, Rustam; Dairi, L B; Siregar, Gontar Alamsyah; Zain, Lukman Hakim

doi:10.1088/1755-1315/125/1/012225

Cited by 1 publication

(1 citation statement)

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“…Cytokines are polypeptides with a broad range of regulatory, inflammatory, metabolic, hematopoietic, and immunological properties. The liver represents a major site for the synthesis and clearance of several cytokines ( Rey et al, 2018 ). IL-1 is a proinflammatory cytokine that plays a crucial role in chronic and acute inflammation.…”

Section: Discussionmentioning

confidence: 99%

Induction of liver fibrosis by CCl4 mediates pathological alterations in the spleen and lymph nodes: The potential therapeutic role of propolis

Sayed

Badr

Hassan

et al. 2021

Saudi Journal of Biological Sciences

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In an animal models, carbon tetrachloride (CCl 4 ) is a carcinogenic agent that causes liver fibrosis. The current study aims to investigate whether induction in liver-fibrosis by CCl 4 in the mouse model could promote the initiation of fibrosis in lymph node and spleen due to sustained increase of inflammatory signals and also aimed to clarify the protective therapeutic effects of propolis. The male mice (BALB/c) were categorized into three experimental sets and each group involved 15 mice. Control group falls into first group; group-II and group-III were injected with CCl 4 to induce liver-fibrosis and oral supplementation with propolis was provided in group-III for 4-weeks. A major improvement with hepatic collagen and α-smooth muscle actin (α-SMA) production was aligned with the activation of liver fibrosis from CCl 4 . Mice treated with CCl 4 exhibited collagen deposition towards liver sections, pathological alterations in spleen and lymph node architectures, and a significantly increase the circulation of both T&B cells in secondary lymphoid organs. Mechanically, the secondary lymphoid organs treated with CCl 4 in mice exposed a positive growth in α-SMA and collagen expression, increased in proinflammatory cytokine levels and a significant increase in TGF-β, NO and ROS levels. A manifest intensification in the expression of Nrf2, COX-2, and eNOS and upregulation of ASK1 and P38 phosphorylation. Interestingly, addition of propolis-treated CCl 4 mice, substantially suppressed deposition of liver collagen, repealed inflammatory signals and resorted CCl 4 -mediated alterations in signaling cascades, thereby repairing the architectures of the secondary lymphoid organs. Our findings revealed benefits of propolis against fibrotic complications and enhancing secondary lymphoid organ architecture.

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Section: Discussionmentioning

confidence: 99%