Serum level of AGE/RAGE as a potential biomarker for acute stroke

千晶, 横田

doi:10.16977/cbfm.26.2_51

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Selective AGEs have been investigated as biomarkers, and high levels of serum pentosidine have been associated with the prediction of poor outcome after acute ischemic stroke [ 141 ]. Similar findings were also reported by Yokota [ 142 ].…”

Section: Oxidative Protein Modificationssupporting

confidence: 92%

The Role of Potential Oxidative Biomarkers in the Prognosis of Acute Ischemic Stroke and the Exploration of Antioxidants as Possible Preventive and Treatment Options

Zahra

Lefter

Jaber

et al. 2023

IJMS

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Ischemic strokes occur when the blood supply to a part of the brain is interrupted or reduced due to arterial blockage, and it often leads to damage to brain cells or death. According to a myriad of experimental studies, oxidative stress is an important pathophysiological mechanism of ischemic stroke. In this narrative review, we aimed to identify how the alterations of oxidative stress biomarkers could suggest a severity-reflecting diagnosis of ischemic stroke and how these interactions may provide new molecular targets for neuroprotective therapies. We performed an eligibility criteria-based search on three main scientific databases. We found that patients with acute ischemic stroke are characterized by increased oxidative stress markers levels, such as the total antioxidant capacity, F2-isoprostanes, hydroxynonenal, total and perchloric acid oxygen radical absorbance capacity (ORACTOT and ORACPCA), malondialdehyde (MDA), myeloperoxidase, and urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine. Thus, acute ischemic stroke is causing significant oxidative stress and associated molecular and cellular damage. The assessment of these molecular markers could be useful in diagnosing ischemic stroke, finding its causes, predicting its severity and outcomes, reducing its impact on the cellular structures of the brain, and guiding preventive treatment towards antioxidant-based therapy as novel therapeutic alternatives.

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Section: Oxidative Protein Modificationssupporting

confidence: 92%