Serum leukocyte cell-derived chemotaxin 2 level is associated with atopic dermatitis patients

Zhao, Keyu; Xu, Feng; Jiang, Xinyu; Chen, Jiong; Zhu, Xiaoxia; Zhou, Qiongyan; Xu, Suling

doi:10.21037/apm-21-2690

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…In addition, Zhao et al. revealed that serum LECT2 is positively correlated with atopic dermatitis and its severity ( 35 ), but the mechanisms of how LECT2 mediates the progression of atopic dermatitis remain unknown.…”

Section: The Roles Lect2 In Immune Diseasesmentioning

confidence: 99%

“…Mounting evidence supports that LECT2 has versatile roles in immune diseases. It attenuates tumorigenesis by modulating TIM ( 51 , 52 ); modulates inflammatory responses in several tissues such as liver ( 7 , 8 , 25 , 40 , 56 , 59 ), bone marrow ( 29 ), joints ( 30 – 33 ), and blood vessels ( 13 , 25 – 27 ); alleviates bacteria/virus-induced sepsis ( 22 , 23 , 42 , 67 – 71 ); and accelerates the progression of allergic diseases ( 35 , 77 ). It also mediates the Wnt/β-catenin pathway to regulate osteogenic differentiation of MSCs ( 28 ).…”

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

“…et al found that LECT2 is involved in modulating delayed-type hypersensitivity responses resulting from Leishmania chagasi infection, but its potential mechanism is unclear (77). In addition, Zhao et al revealed that serum LECT2 is positively correlated with atopic dermatitis and its severity (35), but the mechanisms of how LECT2 mediates the progression of atopic dermatitis remain unknown.…”

Section: Allergic Diseasesmentioning

confidence: 99%

“…Furthermore, more recent research has revealed the link between LECT2 and the development of multiple immunological diseases such as sepsis ( 22 – 24 ), atherosclerosis ( 13 , 25 – 27 ), osteoporosis ( 28 , 29 ), arthritis ( 30 – 33 ), diabetes ( 10 – 12 , 34 ), atopic dermatitis ( 35 ), and non-alcoholic steatohepatitis (NASH) ( 7 , 8 ). Nonetheless, it is disease-dependent for the action mechanisms and signaling of LECT2.…”

Section: Introductionmentioning

confidence: 99%

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The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential

Zhu

Liu²,

Li³

et al. 2023

Front. Immunol.

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Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in diverse physiological and pathological processes. The high sequence similarity of LECT2 among different vertebrates makes it possible to explore its functions by using comparative biology. LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types. In addition, the misfolding LECT2 leads to the amyloidosis of several crucial tissues (kidney, liver, and lung, etc.) by inducing the formation of insoluble fibrils. However, the mechanisms of LECT2-mediated diverse immune pathogenic conditions in various tissues remain to be fully elucidated due to the functional and signaling heterogeneity. Here, we provide a comprehensive summary of the structure, the “double-edged sword” function, and the extensive signaling pathways of LECT2 in immune diseases, as well as the potential applications of LECT2 in therapeutic interventions in preclinical or clinical trials. This review provides an integrated perspective on the current understanding of how LECT2 is associated with immune diseases, with the aim of facilitating the development of drugs or probes against LECT2 for the theranostics of immune-related diseases.

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Section: The Roles Lect2 In Immune Diseasesmentioning

confidence: 99%

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

Section: Allergic Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential

Zhu

Liu²,

Li³

et al. 2023

Front. Immunol.

Self Cite

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show abstract

“…A series of research indicated that the LECT2 protein could play a role in the development and advancement of various conditions. Among immune system diseases like osteoarthritis (20) and rheumatoid arthritis (21), septicemia (22), atherosclerosis, osteoporosis (23), diabetes (18), atopic dermatitis (24), epithelial ovarian cancer (25), and obesity (26), LECT2 can activate and recruit immune cells to regulate inflammatory responses and immune responses (9). LECT2 regulates the bone microenvironment and promotes chondrocyte proliferation (20).…”

Section: Introductionmentioning

confidence: 99%

Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review

Liu,

Wang,

Yeerlan

et al. 2024

Front. Immunol.

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Leukocyte cell-derived chemotaxin-2 (LECT2) is an important cytokine synthesized by liver. Significant research interest is stimulated by its crucial involvement in inflammatory response, immune regulation, disease occurrence and development. However, bibliometric study on LECT2 is lacking. In order to comprehend the function and operation of LECT2 in human illnesses, we examined pertinent studies on LECT2 investigation in the Web of Science database, followed by utilizing CiteSpace, VOSview, and Scimago Graphica for assessing the yearly quantity of papers, countries/regions involved, establishments, authors, publications, citations, and key terms. Then we summarized the current research hotspots in this field. Our study found that the literature related to LECT2 has a fluctuating upward trend. “Angiogenesis”, “ALECT2”, “diagnosis”, and “biliary atresia” are the current investigative frontiers. Our findings indicated that liver diseases (e.g. liver fibrosis and hepatic cell carcinoma), systemic inflammatory disease, and amyloidosis are the current research focus of LECT2. The current LECT2 research outcomes are not exceptional. We hope to promote the scientific research of LECT2 and exploit its potential for clinical diagnosis and treatment of related diseases through a comprehensive bibliometric review.

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Updates on the role of leukocyte cell-derived chemotaxin-2 in inflammation regulation and immunomodulation

Lao,

Zhu,

You

et al. 2024

Cytokine

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Serum leukocyte cell-derived chemotaxin 2 level is associated with atopic dermatitis patients

Cited by 5 publications

References 27 publications

The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential

The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential

Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review

Updates on the role of leukocyte cell-derived chemotaxin-2 in inflammation regulation and immunomodulation

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