Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis

Abstract

Serum LRG concentrations correlate well with disease activity in UC. LRG induction is robust in inflamed colons and is likely to involve an IL-6-independent pathway. Serum LRG is thus a novel serum biomarker for monitoring disease activity in UC and is a promising surrogate for CRP.

LRG1 suppresses the migration and invasion of hepatocellular carcinoma cells

“…Levels of LRG1 expression were negatively correlated with FIGO (International Federation of Gynecology and Obstetrics) stage and lymphatic metastasis [19]. Besides, LRG1 expressions were different in certain kinds of tumors and many benign diseases from healthy subjects [12][13][14][15][16][17][18]. In this study, we first uncovered that the levels of LRG1 mRNA and protein were significantly downregulated in HCC tissues compared with their corresponding peritumoral tissues (Fig.…”

“…It is also involved in promoting neovascularization through binding to the accessory receptor endoglin and causing a switch in transforming growth factor beta (TGF-b) signaling in endothelial cells via the ALK-1/Smad1/5/8 pathway [11]. Serum LRG1 was upregulated in various kinds of benign diseases, such as suspected acute appendicitis of children [12], and activated ulcerative colitis [13]. It could be served as a diagnostic or prognostic biomarker for certain inflammatory conditions in hepatocytes like CRP [14] and neurodegeneration in mouse cerebral cortex [15].…”

Serum leucine-rich α2-glycoprotein is a useful biomarker for monitoring disease activity in patients with adult-onset Still’s disease

“…LRG is reported to be a marker of granulocytic differentiation and elevated serum LRG levels were observed in patients with some inflammatory conditions, such as ulcerative colitis and rheumatoid arthritis (RA) (4)(5)(6). However, there are no studies on the association between serum LRG levels and disease activity and severity in AOSD patients.…”

Molecular Analysis of Inflammatory Bowel Disease: Clinically Useful Tools for Diagnosis, Response Prediction, and Monitoring of Targeted Therapy

“…MMP-9 positively correlated with disease activity in children Both positively correlated with disease activity in children Low [87,88] ACP antibodies to the CD peptide, anti-PR3 ANCA anti-proteinase 3 anti-neutrophil cytoplasmic antibodies, CaINAc/HP N-acetylgalactosamines per hinge glycopeptide, CD Crohn's disease, CgA chromogranin A, GM-CSF Ab granulocyte-macrophage colony-stimulating factor antibody, GP glycoprotein, IBS irritable bowel syndrome, IBS-D IBS-diarrheal subtype, LRG leucine-rich alpha-2 glycoprotein, MMP matrix metalloproteinase, PAB pancreatic autoantibodies, UC ulcerative colitis a 'Controls' refers to healthy controls [64,66,70,72,74,75], unaffected controls [67], patients with IBS-D or healthy controls [81], and functional dyspepsia and IBS [87,88] b See the text for an explanation of 'deficient rate' 2.2.2.6 Soluble ST2 ST2 is member of the interleukin (IL)-1 receptor family with IL-33 as its ligand. Both IL-33 and ST2 have been shown to be dysregulated in UC and murine experiment colitis [72].…”

“…Leucine-Rich Alpha-2 Glycoprotein Serum LRG has recently been shown to be a disease activity biomarker in UC [75]. LRG is an (almost equal to) 50 kDa glycoprotein and contains repetitive sequences with a leucinerich motif [76].…”