Serum Leptin, Resistin, and Lipid Levels in Patients with End Stage Renal Failure with Regard to Dialysis Modality

Taşkapan, Mehmet Çağatay; Taşkapan, Hülya; Şahin, İ̇brahim; Keskin, Lezzan; Atmaca, Hasan; Özyalın, Fatma

doi:10.1080/08860220601095827

Cited by 28 publications

(11 citation statements)

References 37 publications

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“…Renal dysfunction has been associated with elevated resistin levels(35–37), though in our study SLE was associated with higher resistin levels independent of GFR. In addition, CRP and Hcy have recently been shown to upregulate resistin production from PBMC and adipocytes, respectively(18, 38).…”

Section: Discussioncontrasting

confidence: 67%

Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification

Baker¹,

Morales²,

Qatanani³

et al. 2011

J Rheumatol

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Objective To evaluate levels of resistin in female subjects with systemic lupus erythematosus (SLE) compared to age and race-matched controls and to determine the relationship between resistin and systemic inflammation, disease measures, and coronary artery calcification(CAC). Methods Resistin levels were measured on stored samples from 159 female SLE subjects and 70 age and race-matched controls as an extension of a previous cross-sectional study. Spearman correlations and multivariable regressions were used to examine whether resistin levels were associated with SLE, disease-specific and inflammatory markers, insulin resistance, and CAC. Results In a multivariable linear regression model, a diagnosis of SLE was significantly associated with higher resistin levels independent of age, race, renal function, body mass index (BMI), high-sensitivity CRP (hsCRP), hypertension, diabetes and steroid use. In SLE, resistin levels positively correlated with SLICC Damage Index, GFR, hsCRP, ESR, homocysteine, and disease duration (all p<0.03). Resistin level did not correlate with markers of insulin resistance or body adiposity, including homeostatic model assessment or BMI. Resistin levels were significantly elevated in SLE cases with CAC compared to cases without CAC (16.58 v. 13.10 ng/ml, p= 0.04). However, in multivariate logistic regression, the association not present after adjustment for age, race, and GFR. Conclusion SLE was independently associated with higher resistin levels. Among SLE, higher resistin correlated positively with renal dysfunction, inflammatory markers, and disease damage but not with insulin resistance or BMI. SLE cases with CAC had higher resistin levels than cases without CAC, however, this relationship was dependent on other established risk factors.

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Section: Discussioncontrasting

confidence: 67%

Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification

Baker¹,

Morales²,

Qatanani³

et al. 2011

J Rheumatol

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“…Besides, omentin is a relatively large protein, 40 kDa [19], which during hemodialysis may not be significantly cleared from plasma. Currently there is no study supporting our estimation related to omentin excretion, but generally most adipokines such as adiponectin, visfatin and resistin are elevated in patients with CKD, likely owing to decreased renal excretion [20,21,22,23,24]. …”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Omentin in End-Stage Renal Disease Patients

Alçelik

Tosun²,

Özlü³

et al. 2012

Kidney Blood Press Res

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Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients. Therefore, evaluation and prevention of cardiovascular diseases in end-stage renal disease (ESRD) patients are very important. The plasma level of omentin was found to be associated with different conditions such as insulin resistance. It is one of the novel adipokines synthesized mainly in the visceral adipose tissue. In this study, we aimed to investigate the level of omentin in patients with ESRD receiving hemodialysis. Methods: The study population consisted of 59 adult chronic hemodialysis patients (30 women and 29 men) and age-matched control subjects were selected from apparently healthy subjects (28 participants; 14 women and 14 men). Blood samples were obtained before the dialysis session. Omentin concentrations were determined by using enzyme-linked immunosorbent assay. Results: Plasma levels of omentin were found to be markedly higher in ESRD patients (606.6 ± 313.0 ng/ml) than in the control group (357.5 ± 147.4 ng/ml; p < 0.0001). Also, serum omentin levels were found to be correlated with creatinine (r = 0.333, p = 0.002). Conclusions: Omentin levels were found to be elevated in patients with ESRD receiving hemodialysis. To the best of our knowledge, this is the first clinical study that demonstrated the association between omentin and ESRD.

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“…Few studies on resistin observed longitudinal clinical outcomes unlike studies on leptin or adiponectin. Some reports have shown no correlation between resistin and inflammatory cytokines (26, 27). It is possible that resistin levels may predict poor hospital-free survival independently of inflammation in our hemodialysis patients.…”

Section: Discussionmentioning

confidence: 99%

Low Resistin Level is Associated with Poor Hospitalization-Free Survival in Hemodialysis Patients

et al. 2012

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Malnutrition and inflammation are related to high rates of morbidity and mortality in hemodialysis patients. Resistin is associated with nutrition and inflammation. We attempted to determine whether resistin levels may predict clinical outcomes in hemodialysis patients. We conducted a prospective evaluation of 100 outpatients on hemodialysis in a single dialysis center (male, 46%; mean age, 53.7 ± 16.4 yr). We stratified the patients into 4 groups according to quartiles of serum resistin levels. During the 18-month observational period, patients with the lowest quartile of serum resistin levels had poor hospitalization-free survival (log rank test, P = 0.016). After adjustment of all co-variables, patients with the lowest quartile of serum resistin levels had poor hospitalization-free survival, compared with reference resistin levels. Higher levels of interleukin-6 were an independent predictor of poor hospitalization-free survival. In contrast, serum resistin levels were not correlated with interleukin-6 levels. The current data showed that low resistin levels may independently predict poor hospitalization free survival in hemodialysis patients.

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Serum Leptin, Resistin, and Lipid Levels in Patients with End Stage Renal Failure with Regard to Dialysis Modality

Cited by 28 publications

References 37 publications

Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification

Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification

Serum Levels of Omentin in End-Stage Renal Disease Patients

Low Resistin Level is Associated with Poor Hospitalization-Free Survival in Hemodialysis Patients

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