Serum Leptin Levens and Hepatocellular Carcinoma: Review Article

Andrighetto, Luiza Vitelo; Poziomyck, Aline Kirjner

doi:10.1590/0102-6720201600040015

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Additionally, all three dietary patterns have been associated with higher circulating sex‐hormone binding globulin (SHBG) levels, but lower leptin levels . A high circulating level of SHBG has been associated with increased risk of HCC, and leptin may play a role in HCG through modulation of human telomerase reverse transcriptase (a critical player of carcinogenesis) . Therefore, healthy dietary patterns might influence HCC risk through their potential impact on insulin resistance and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…(40) A high circulating level of SHBG has been associated with increased risk of HCC, (41) and leptin may play a role in HCG through modulation of human telomerase reverse transcriptase (a critical player of carcinogenesis). (42) Therefore, healthy dietary patterns might influence HCC risk through their potential impact on insulin resistance and inflammation. We found stronger inverse associations with AHEI-2010 than with DASH and AMED.…”

Section: Discussionmentioning

confidence: 99%

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Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Yang

Simon

et al. 2019

Hepatology

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Although adherence to healthy dietary guidelines has been associated with a reduced risk of several health outcomes, including cardiovascular diseases, type 2 diabetes, and some cancers, little is known about the role of dietary patterns in the development of hepatocellular carcinoma (HCC). We prospectively assessed the associations of three key commonly used a priori dietary patterns—the Alternative Healthy Eating Index‐2010 (AHEI‐2010), Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH)—with risk of incident HCC in the Health Professionals Follow‐Up Study (HPFS) and the Nurses’ Health Study (NHS), two large prospective cohort studies. Diet was assessed almost every 4 years using validated food frequency questionnaires (FFQs). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. During up to 32 years of follow‐up, 160 incident HCC cases were identified. After adjustment for most HCC risk factors, participants in the highest tertile of Alternative Healthy Eating Index‐2010 (AHEI‐2010) had a multivariable HR of 0.61 (95% CI, 0.39‐0.95; Ptrend = 0.03), compared with those in the lowest tertile. There was a suggestive, but nonsignificant, inverse association for Alternate Mediterranean Diet (AMED; HR = 0.75; 95% CI, 0.49‐1.15; Ptrend = 0.18) and a null association for Dietary Approaches to Stop Hypertension (DASH; HR = 0.90; 95% CI, 0.59‐1.36; Ptrend = 0.61) in relation to the risk of HCC development. Conclusion: Our findings suggest that better adherence to the AHEI‐2010 may decrease the risk of developing HCC among U.S. adults. Future studies are needed to replicate our results, examine these associations in other populations, and elucidate the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Yang

Simon

et al. 2019

Hepatology

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“…Moreover, increased serum leptin levels were found to be a risk factor for recurrent phase I/II of HCC after curative treatment [25]. Serum leptin levels are significantly increased in cirrhotic patients independent of the presence of HCC [202] and are not associated with the development of HCC in cirrhosis [202,203].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Hepatokines and adipokines in NASH-related hepatocellular carcinoma

Kücükoglu

Sowa

Mazzolini

et al. 2021

Journal of Hepatology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Finally, obesity, particularly abdominal obesity, also confers an increased risk of developing HCC according to various epidemiological studies. This risk seems to be related to the adipose tissue production of adipokines (leptin, adiponectin and resistin)[ 14 ]. Interestingly, the serum levels of leptin are elevated in patients with HCC, which points to the role of this adipokine as a promoter of HCC in obese patients.…”

Section: Dietary Involvement In Hcc Developmentmentioning

confidence: 99%

Nutritional therapy for hepatocellular carcinoma

Ruiz-Margáin¹,

Román-Calleja²,

Moreno-Guillén³

et al. 2021

WJGO

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Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and presents together with cirrhosis in most cases. In addition to commonly recognized risk factors for HCC development, such as hepatitis B virus/hepatitis C virus infection, age and alcohol/tobacco consumption, there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat, type of cooking (generation of heterocyclic amines) and contamination of foods with aflatoxins. On the contrary, protective nutritional factors include diets rich in fiber, fruits and vegetables, n-3 polyunsaturated fatty acids and coffee. While the patient is being evaluated for staging and treatment of HCC, special attention should be paid to nutritional support, including proper nutritional assessment and therapy by a multidisciplinary team. It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis, and therefore they could present with severe malnutrition. Cirrhosis-related complications should be properly addressed and considered for nutritional care. In addition to traditional methods, functional testing, phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment. Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer. Supplementation with branched-chain amino acids is also recommended as it improves response to treatment, nutritional status and survival, and finally physical exercise must be encouraged and adapted to individual needs.

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Serum Leptin Levens and Hepatocellular Carcinoma: Review Article

Cited by 6 publications

References 25 publications

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Hepatokines and adipokines in NASH-related hepatocellular carcinoma

Nutritional therapy for hepatocellular carcinoma

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