Serum Leptin Levels in Pemphigus: A Case Control Study

Mozafari, Nikoo; Robati, Reza M.; Younespour, Shima

doi:10.1155/2014/853705

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…46 However, the observed dyslipidaemia was predominantly caused by the cases' corticosteroid treatments, not solely pemphigus itself. [48][49][50] Drugs No relevant case-control studies were identified. [48][49][50] Drugs No relevant case-control studies were identified.…”

Section: Pemphigusmentioning

confidence: 99%

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A review of case–control studies on the risk factors for the development of autoimmune blistering diseases

Zhao

Murrell

2015

Acad Dermatol Venereol

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Autoimmune blistering diseases (AIBD) are a group of rare but potentially fatal diseases characterized by the production of autoantibodies directed against the structural proteins of the skin. Much has been published on the clinical manifestation and interventional options for AIBD, especially on the more common subtypes such as bullous pemphigoid, pemphigus vulgaris (PV) and pemphigus foliaceus (PF). However, the aetiology of AIBD remains unknown. We aim to provide an overview of published case-control studies focussing on the non-genetic aetiological factors of bullous pemphigoid, PV and/or PF. The relevant studies were appraised for their validity and results. Our results showed that a large proportion of the studies had inconclusive results due to compromised study methodologies. Moreover, there were no identified case-control studies that investigated the possible associations between bullous pemphigoid and patient environment, or the potential links between pemphigus and drugs. Hence, a case-control study with a higher quality design addressing these shortcomings would contribute greatly to our knowledge of AIBD.

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Section: Pemphigusmentioning

confidence: 99%

“…47 Other factors that were investigated by case-control studies but showed no significant associations with pemphigus include autoimmune thyroid disease, Coxsackie virus infection and elevated/decreased serum leptin level. [48][49][50] Drugs No relevant case-control studies were identified.…”

Section: Pemphigusmentioning

confidence: 99%

A review of case–control studies on the risk factors for the development of autoimmune blistering diseases

Zhao

Murrell

2015

Acad Dermatol Venereol

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“…The role of various cytokines such as leptin (Mozafari, Robati, & Younespour, 2014) and interleukins 4 (Tavakolpour & Tavakolpour, 2016), 35 (Tavakolpour et al, 2017), and 21 (Tavakolpour, 2016) as well as sex hormones (Yousefi et al, 2016) and vitamin D (Moravvej, Mozafari, & Younespour, 2016) in the pathogenesis of pemphigus have also been noted in previous studies.…”

Section: Discussionmentioning

confidence: 69%

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Ketabi

Nasiri

Kheirodin

et al. 2019

Dermatologic Therapy

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Background Pemphigus vulgaris (PV) is a life‐threatening autoimmune disease with no certain treatment. Anticytokine therapy is being increasingly discussed in multiple autoimmune diseases. Osteopontin (OPN) is a glycoprotein produced by a variety of immune cells. Increased OPN serum levels have been reported in several autoimmune diseases, with targeting OPN considered as a promising therapy in these diseases. However, the role of OPN in PV has not been well studied so far. Objective To investigate whether OPN level is elevated in PV patients in the active stage of the disease and to examine its possible relationship with disease severity and anti‐desmoglein (anti‐Dsg) antibodies levels. Materials and Methods This study included 53 consecutive subjects affected by PV and 38 age‐ and sex‐matched healthy controls. Clinical characteristics and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) were assessed. Serum OPN levels (pg/mL) and anti‐Dsg antibodies were also measured. Results The serum OPN level of the patient group proved to be statistically higher than that of the control group (11.08 ± 5.24 vs 8.47 ± 5.68; p = .02). No significant relationship were detected between the serum OPN level and anti‐Dsg1 or anti‐Dsg3 antibodies (r = 0.1, p = .2 and r = 0.1, p = .4), respectively. In addition, no correlation was found between serum OPN levels and severity of PV as measured by ABSIS (r = 0.08 and p = .5). Conclusion The growth observed in OPN levels in pemphigus patients suggests the role of OPN in pemphigus pathogenesis, but there is a need for more extensive studies to show how OPN can be associated with the PV pathogenesis and whether OPN could be used as an important therapeutic target in pemphigus disease.

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Electrocardiographic changes after high-dose corticosteroid pulse therapy in pemphigus patients

Pishgahi

Dadkhahfar

Robati

et al. 2018

Journal of Dermatological Treatment

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Serum Leptin Levels in Pemphigus: A Case Control Study

Cited by 3 publications

References 16 publications

A review of case–control studies on the risk factors for the development of autoimmune blistering diseases

A review of case–control studies on the risk factors for the development of autoimmune blistering diseases

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Electrocardiographic changes after high-dose corticosteroid pulse therapy in pemphigus patients

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