Serum leptin levels in hypo- and hyperthyroidism

Leonhardt, U.; Ritzel, Uwe; Schäfer, Günter; Becker, Walter; Ramadori, Giorgio

doi:10.1677/joe.0.1570075

Cited by 88 publications

(72 citation statements)

References 27 publications

(17 reference statements)

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“…Some studies related to hyperthyroid state before and after treatment have shown identical leptin levels to those of controls [9,10]. However, other studies showed that the serum leptin concentration increased during anti-thyroid drug therapy [11,12].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that this hypoleptinaemia might be related more to the degree of adiposity than to the levels of thyroid hormones [13]. Serum leptin levels may be unchanged [15,16], elevated [9,14,17,18] or even decreased [10,19] as a result of hypothyroidism. Some studies suggest that the activity of the PTA is related to serum leptin levels in patient with thyroid disease, and raise the interesting possibility of a functional link between these two endocrine axes.…”

Section: Discussionmentioning

confidence: 99%

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TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

et al. 2005

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Abstract. Leptin is considered to play a role in maintenance of energy balance and body weight by neuroendocrine mechanisms. The physiological mechanisms for thyroid hormone-induced alteration in serum leptin are not well known. In the present study, the relationship between thyroid hormones and leptin levels was investigated in patients with overt hypothyroidism and hyperthyroidism before and after successful treatment. Leptin levels were determined by radioimmunoassay and body mass index (BMI) was calculated for each subject. Serum leptin levels of 26 hypothyroid and 22 hyperthyroid patients were compared with those of 20 healthy volunteers who comprised the controls. Serum leptin levels of hypothyroid patients (28.4 ± 4.1 ng/ml) were found to be significantly higher than the controls (19.1 ± 3.2 ng/ml) (p<0.01), whereas hyperthyroid patients had lower levels (10.7 ± 1.2 ng/ml) (p<0.01). In hypothyroid patients, serum leptin levels were decreased significantly to 20.6 ± 2.1 ng/ml with thyroxin treatment (p<0.05). However, in hyperthyroid group, serum leptin levels were increased to 12.4 ± 2.2 ng/ml by treatment (p>0.05). BMI was not changed with the treatment in either group. The serum leptin levels were correlated with BMI and thyrotropin (TSH) in both hypothyroid and hyperthyroid patients. Serum leptin levels are affected in thyroid disorders and the correlation of leptin with TSH is independent of thyroid hormones.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

et al. 2005

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“…In hyperthyroidism, increased (9 -11), decreased (12 -16) as well as unaffected (17 -20) serum levels of leptin have been observed, whereas unaltered (10,13,17,18) or increased (11,14,18,20) levels are reported in hypothyroidism. A gender-related regulation of Comparisons were made using Student's paired (*) or unpaired (**) t-tests.…”

Section: Discussionmentioning

confidence: 99%

Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism

Wahrenberg

Wennlund

Hoffstedt

2002

European Journal of Endocrinology

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Objective: This study was designed to investigate adipose tissue secretion of interleukin-6 (IL-6), leptin, tumour necrosis factor alpha (TNF-a) and plasminogen activator inhibitor-1 (PAI-1) in Graves' hyperthyroidism. Design: We studied 10 patients before and during (after 8 weeks) anti-thyroid treatment for Graves' hyperthyroidism and 16 healthy, euthyroid control subjects. Methods: Plasma levels of thyroid hormones and serum/plasma levels of IL-6, leptin, TNF-a and PAI-1 were analysed. Subcutaneous fat biopsies were taken for subsequent measurement of IL-6, leptin, TNF-a and PAI-1 protein secretion. Results: In patients with Graves' disease, the anti-thyroid treatment resulted in significant reductions of plasma thyroxine and triiodothyronine levels. No differences in serum concentration or adipose tissue secretion of leptin or TNF-a were observed either before, as compared with during, anti-thyroid treatment, or in comparison with euthyroid controls. In contrast, plasma PAI-1 activity, but not adipose tissue secretion of PAI-1, was increased both in Graves' disease before as compared with during anti-thyroid treatment ðP ¼ 0:01Þ and in thyrotoxic patients compared with euthyroid controls ðP ¼ 0:0001Þ: Finally, adipose secretion of IL-6 was increased both before (8-fold, P ¼ 0:001) and during (6-fold, P , 0:0001) treatment as compared with control subjects. Accordingly, serum concentration of IL-6 was also increased by about 50% in thyrotoxic patients as compared with healthy controls ðP ¼ 0:03Þ: Conclusions: In Graves' hyperthyroidism regardless of thyroid status, adipose tissue secretion of IL-6, but not of leptin, TNF-a or PAI-1, is markedly increased in comparison with euthyroid controls. This suggests that autoimmune thyroidal disorder may regulate adipose tissue release of IL-6.

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“…Healthy volunteers showed no short-term in¯uences of thyroid function on leptin concentrations. 21 In contrast, elevated plasma leptin was reported in hypothyroid animals 19,20 and hypothyroid patients 18,22 and decreased levels in thyrotoxic patients as compared to euthyroid controls. 23 The present study assessed, in hyperthyroid patients, the in¯uence of radioiodine therapy on thyroid function, plasma leptin concentrations and body mass index (BMI) as well as proportional fat tissue (PFT) during a one-year follow-up.…”

Section: Introductionmentioning

confidence: 91%

“…9 This was con®rmed by human experiments. 3,10 Elevated plasma leptin values were reported in hyperthyroid patients, 11,12 decreased plasma leptin values in hypothyroid patients, 13,14 but other studies showed no in¯u-ence of altered thyroid function 15 ± 17 or hyperthyroidism 18 on plasma leptin concentrations. Healthy volunteers showed no short-term in¯uences of thyroid function on leptin concentrations.…”

Section: Introductionmentioning

confidence: 98%

Dissociation of leptin and body weight in hyperthyroid patients after radioiodine treatment

et al. 2001

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OBJECTIVE: Leptin regulates energy production rates and body weight, which are frequently altered in hyperthyroidism. Data on a possible interaction between leptin and thyroid hormones are controversial. We assessed leptin serum concentrations, BMI, proportional fat tissue mass and thyroid hormones in hyperthyroid patients in a long-term follow-up after radioiodine therapy. DESIGN: The study included 28 hyperthyroid patients (mean age 66 y) before and up to one y after radioiodine therapy. Leptin and thyroid hormones, general parameters, BMI, proportional fat tissue (PFT) measurements by DEXA and thyroid morphology were recorded. Twenty-four age-matched euthyroid individuals (mean age 63 y) served as controls. RESULTS: At baseline, leptin concentrations were signi®cantly decreased in all hyperthyroid patients as compared to controls. One year after radioiodine therapy, 71% of the patients were euthyroid (group A) and 29% remained hyperthyroid (group B). BMI and PFT increased in both groups. While leptin concentrations remained low in group B, they normalised in group A after 6 to 12 months. Changes in leptin and thyroid hormone concentrations were positively correlated in group A patients (r 0.49, P 0.03) but not in patients remaining hyperthyroid. CONCLUSION: Our data indicate a dissociation in the regulation of plasma leptin and BMI as well as proportional fat tissue in hyperthyroid patients which may be attributable to differences in lean and adipose mass weight gain after radioiodine therapy or direct in¯uences of thyroid hormones on leptin regulation.

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Serum leptin levels in hypo- and hyperthyroidism

Cited by 88 publications

References 27 publications

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism

Dissociation of leptin and body weight in hyperthyroid patients after radioiodine treatment

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