Serum Leptin Level Is a Predictor of Bone Mineral Density in Postmenopausal Women

Blain, Hubert; Vuillemin, Anne; Guillemin, Françis; Durant, R.; Hanesse, B.; Talancé, Nicole de; Doucet, Brigitte; Jeandel, Claude

doi:10.1210/jcem.87.3.8313

Cited by 144 publications

(43 citation statements)

References 69 publications

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“…Percentage body fat was also 14·9 (SD 2·0) % greater in the HFS v. LFCC cohort (P, 0·001). As bone mineral density and bone size are influenced by total body mass (30) , and as bone mineral density influences bone strength (31) , structural properties presented below were adjusted (divided by grams of body mass) as has been done previously in studies where body weight differs substantially between groups (15,24,25,32 -35) .…”

Section: Body Massmentioning

confidence: 99%

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

et al. 2009

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Exposure to diets high in fat and sucrose can induce hyperinsulinaemia, affect Ca and Mg metabolism, and alter bone mineralisation and mechanical properties. The present study assessed morphological and mechanical changes in a murine model exposed to a high-fat/sucrose (HFS) diet, as well as corresponding molecular and endocrine markers of bone turnover. Female C57BL/6 mice (aged 9 weeks) consumed either a low-fat, complex carbohydrate diet or an HFS diet for 10 weeks. At the end of the 10 weeks, serum was collected for biochemical analysis. Tibiae from half the mice (n 15) were randomly selected to be micro-computed tomography scanned and tested to failure in cantilever bending, while the remaining half were prepared for real-time PCR analysis. Serum tartrate-resistant acid phosphatase was significantly elevated in HFS mice, while osteocalcin remained unchanged. Both body mass and percentage body fat were greater in mice fed HFS diet. After adjusting for body mass, tibial structural and morphological properties were adversely affected in the HFS cohort. Cortical thickness, cross-sectional area, and load at maximum were all significantly lower in mice fed HFS diet. Receptor activator of nuclear factor kb ligand (RANKL) mRNA was significantly upregulated in HFS mice, but osteoprotegerin/RANKL mRNA ratio remained unchanged between cohorts. Moreover, cyclo-oxygenase-2 mRNA tended to be increased in HFS. Thus, ingestion of an HFS diet had a significant adverse effect on mouse bone morphology and mechanics, and these effects were likely due to elevated osteoclast activity associated with the inflammatory state of obesity, and not necessarily osteoclast recruitment/ proliferation.Cortical bone: High-fat/sucrose diet: Biomechanics: C57BL/6 mice The changing face of disease aetiology over the past century has brought to the forefront the need to examine the environmental or modifiable risk factors that have influenced the epidemic of chronic disease afflicting a majority of the Western world. Nutritional status is a readily modifiable risk factor linked to numerous chronic conditions, including CHD, cancer, obesity, diabetes and osteoporosis (1,2) . Nonetheless, despite the prevalence of research linking poor dietary choices to chronic disease status, the nutritional patterns presently dominating most Western nations continue to be high in saturated fats, Na and refined carbohydrates from sugars, cereals and dairy products, and low in fruits, vegetables and lean protein (3) .Considerable effort has focused on discovering the underlying nutritional factors that predispose an individual to osteopenia or osteoporosis and subsequent fracture (4) . Much research has concentrated on the role of Ca and vitamin D metabolites influencing bone morphology and mechanics; however, macronutrients such as fat, protein and carbohydrate also play a vital role in bone health (5) . Considered independently, consumption of diets composed of large amounts of saturated fat has been documented to cause the formation of insoluble soap complexe...

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Section: Body Massmentioning

confidence: 99%

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

et al. 2009

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“…On the other hand, Madsen et al (19) suggest that the body weight composition, including the lean and fat masses, might be more important than the body weight individually, suggesting that the fat, as a substrate to the conversion of the androgen to estrogen (26) may be related to the BMD both due to hormonal factors because of their importance in regulating sexual hormones in the BMD (5,24) , and to mechanical factors. Related to the lean mass, it can be related to the BMD because although they are structurally independent, both respond to the same atrophy and hypertrophy stimuli (25) .…”

Section: Bmd Muscular Strength and Body Compositionmentioning

confidence: 99%

“…Although the majority of studies emphasize the effect of the type of the physical exercise on the BMD, other factors seem to interfere in that variable as well, such as the muscular strength (25) and the body composition (6,19,26) . In this perspective, regardless the level of the physical activity, some studies have shown that BMD in physically active output athletes or even the sedentary ones seem to pursue an association to their muscular strength developed according to the type of the physical exercise or daily activity, and their body composition (6,19,25,26) . Based on the aspects approached in the above mentioned studies, the aim of this article is to make a review on the effects of different sportive modalities and the strength training on the bone health, and also to analyze its possible benefic or harmful mechanism.…”

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confidence: 99%

Efeitos da atividade física na densidade mineral óssea e na remodelação do tecido ósseo

Cadore

Brentano

Kruel

2005

Rev Bras Med Esporte

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The purpose of this article is to make a review on different sportive modalities and the power training on the bone remodeling, and to discuss the possible relationship of the bone mineral density (BMD) to the muscular power and body composition. Several studies indicate that the high impact physical activity or physical activities demanding a high power production may have a benefic effect on the BMD due to the deformation that occurs in such tissue during the activity. Some authors have been assessing the effects of the physical training on some biochemical markers of the bone remodeling, since the variation on the concentrations of these markers might indicate a bone turnover or reabsorption state. Nevertheless, the inconsistency of the results found suggests that the analysis of the effects of the physical activity on the bone remodeling through these markers must be further investigated. There are many discrepancies as to the relationship of the BMD to the muscular power and body composition, mainly to determine what factors are most associated to the BMD. The determination of what type of physical activity is the ideal to increase the bone mass peak during the adolescence or even aiming to keep it later in the adult years is quite important in order to prevent and possibly treat the osteoporosis.

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“…There are studies where a positive association has been found between leptin and BMD (14,23) while there are also studies reporting no significant association (8,24) or a negative association (13,25) Yamauchi et al (26) claimed that there is a relation between low plasma leptin levels and vertebral fractures in postmenapousal women and thus circulating leptin might play a physiological role in improving bone mass quality. Unsurprisingly, insulin values of the patients were significantly higher than controls, independent of gender.…”

Section: Discussionmentioning

confidence: 99%

Association between serum leptin level and osteoporosis in patients with type 2 diabetes mellitus

Demi̇r¹,

Gültürk²,

Özdemir³

et al. 2013

Basic Clin Sci

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Aim: As osteoporosis and diabetes mellitus are widespread diseases, it is an important question whether leptin plays a role in bone physiology or not. In this study, we aimed to investigate the relationship between serum leptin level, diabetes and osteoporosis. Methods: The present study was conducted on 49 healthy individuals and 77 patients with type 2 Diabetes mellitus (DM), a total of 126 individuals, between 40 and 60 of ages. Between 08-10 hours in the morning, venous blood samples of 15 mL were drawn from forearm veins of the individuals and transferred into concerned test tubes. After blood samples were taken, Bioelectrical Impedance Analysis (BIA) was performed. Bone mineral density (BMD) was measured by DEXA (Dual energy X-ray absorptiometry) at L 1-4 (anterior-posterior) and femur. Student t test and correlation analysis were used for the statistical analysis in the study. Results: Leptin level of women in both groups were significantly higher than those of men in both groups (p<0.05). BMD values of men in patient group was significantly lower compared to those of men in control group (p<0.05). Similarly, BMD values of women in patient group was significantly lower compared to those of women in control group (p<0.05). A positive correlation was found

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Serum Leptin Level Is a Predictor of Bone Mineral Density in Postmenopausal Women

Cited by 144 publications

References 69 publications

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

Efeitos da atividade física na densidade mineral óssea e na remodelação do tecido ósseo

Association between serum leptin level and osteoporosis in patients with type 2 diabetes mellitus

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