Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

Abdullah, Abdullah Abdulslam; Ahmed, Musa; Oladokun, Adesina; Ibrahim, Nasir Adam; Adam, Shahd Nourain

doi:10.4331/wjbc.v13.i5.83

Cited by 3 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated leptin levels have also been observed in various autoimmune diseases. 65,70 Abdullah et al 71 reported elevated leptin levels in women with unexplained infertility. High levels of leptin in serum and follicular fluid in women undergoing in vitro fertilization were negatively correlated with a non-receptive endometrium, rate of good quality embryos, and clinical pregnancy rate.…”

Section: Adipokinesmentioning

confidence: 99%

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

Gonçalves,

Feitosa,

Cavalcante

et al. 2023

American J Rep Immunol

View full text Add to dashboard Cite

Currently, obesity is considered a global public health problem. It is the main risk factor for noncommunicable diseases and reproductive complications, such as recurrent miscarriage (RM). RM affects approximately 1% of couples of reproductive age, and recent studies suggest that its prevalence is increasing. Immunological abnormalities may be responsible for a significant number of cases of unexplained RM. Obesity is recognized as a chronic low‐grade inflammatory condition. The accumulation of fat in obese adipose tissue promotes changes in the local and systemic immune response. Adipokines, exosomes, micro‐RNAs, lipids, and other factors released or secreted by adipose tissue are responsible for the interconnection between obesity and the immune system. Obesity‐induced dysregulation of the innate and acquired immune response is also involved in the immunopathology of pregnancy loss in patients with unexplained RM. Therefore, understanding the communication pathways between maternal adipose tissue and the immune response in women living with obesity and RM is an important objective. Thus, diagnostic tools and new immunomodulatory therapies may be proposed for the management of patients with concurrent obesity and RM.

show abstract

Section: Adipokinesmentioning

confidence: 99%

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

Gonçalves,

Feitosa,

Cavalcante

et al. 2023

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Gaznee¹,

Kohli²,

Kumar³

2023

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

If you and your spouse have been trying to conceive for a year and neither of you has been successful, there is a possibility that you are one of the 50–80 million people throughout the world who struggle with infertility. There is a male component present in approximately 20%-30% of these instances. It is common knowledge that low-quality sperm and oxidative stress (OS) both have a role in the aetiology of male infertility. Because of the oxidation of DNA, proteins, and lipids, excessive levels of reactive oxygen species (ROS) have the potential to disrupt the viability, motility, and morphology of sperm cells. ROS are responsible for these changes. Methods: Through the use of the PubMed interface, we searched the MEDLINE database for studies that had been completed and published during the past ten years that analysed the effect that antioxidants had on sperm in infertile guys (2012–2022). A number of different phrases, including infertility, alpha-lipoic acid, zinc, folate, coenzyme Q10, selenium, and vitamin, were utilised during the search. The study's findings indicate that inositol serves a purpose in a number of different mechanisms that foster contacts between sperm and oocytes, and that it also affects OS levels in sperm cells by way of its engagement in mitochondrial events. Alpha-lipoic acid (ALA) lessens the damage caused by reactive oxygen species (ROS) and improves the quality of sperm in a number of ways, including motility, morphology, and count. There might be a connection between not getting enough zinc in your diet and having low-quality sperm. Zinc and folate are two nutrients that can boost the quantity and quality of sperm. When taken orally, coenzyme Q10 increases the number of sperm as well as their overall motility and forward movement. A therapy with selenium (Se) results in an improvement in the sperm's overall quality, and this improvement is connected with an increase in ejaculatory production. Only vitamin B12 has been found to improve the quality of sperm; it does this by boosting sperm count and motility and by decreasing sperm DNA damage. Vitamin B12 is the only vitamin that has been proved to do this. Conclusions: Dietary supplementation with antioxidants may improve sperm quality in men with low-quality semen by reducing OS-induced sperm damage and increasing hormone synthesis and spermatozoa concentration, motility, and morphology. This may be achieved in men who also have low levels of antioxidants in their semen. Antioxidants can exert their effects in a variety of ways; hence, it is important for researchers conducting future clinical trials to study the possibility of combining a number of antioxidants.

show abstract

Characterization and risk factors for unexplained female infertility in Sudan: A case-control study

Abdullah¹,

Ahmed²,

Oladokun³

2023

World J Methodol

View full text Add to dashboard Cite

Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

Cited by 3 publications

References 38 publications

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Characterization and risk factors for unexplained female infertility in Sudan: A case-control study

Contact Info

Product

Resources

About