Serum Leptin in Overt and Subclinical Hypothyroidism: Effect of Levothyroxine Treatment and Relationship to Menopausal Status and Body Composition

Teixeira, Patrícia de Fátima dos Santos; Cabral, Mônica Dias; Silva, Nathalie A.; Soares, Débora Vieira; Braulio, Valéria Bender; Couto, Ana Paula C.B.; Henriques, Jodélia L. M.; Costa, Antônio José Leal; Buescu, Alexandru; Vaisman, Mário

doi:10.1089/thy.2007.0393

Cited by 25 publications

(23 citation statements)

References 26 publications

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“…The minimum reference value of TSH ranged from 0.17 to 0.5 mU/l, whereas the maximum reference value of TSH ranged from 3.5 to 5.5 mU/l. Anthropometric measures used in the studies included BMI (4-6, 9-30), body weight (15,31,32), waist circumference (9,14,15,23,29,33), waist-hip ratio (9,15), hip (23), body fat percentage (13,15,17,21,23,29,32), subcutaneous (9,15,21,27) and central (21) fat, and fat mass index (fat mass (kg)/height (m)…”

Section: Resultsmentioning

confidence: 99%

“…However, 18 of the 29 examined studies considered an upper-limit TSH value of over 4 mU/l. This variability in limits might explain the lack of association between BMI and TSH in 11 (5,9,13,16,19,23,25,28,29,33,40) of the 29 examined studies. Another source of discrepancy is the fact that almost half of the studies did not perform adjustment for potential confounders.…”

Section: Discussionmentioning

confidence: 99%

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Association between serum TSH concentration within the normal range and adiposity

Souza

Sichieri²

2011

European Journal of Endocrinology

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Background: Overt hypothyroidism is clearly related to body weight gain and greater adiposity, but the range of hormonal change in serum TSH concentration associated with weight gain remains a focus of debate. Aim: The aim of this review was to assess studies that evaluated the relationship between anthropometric measures and serum TSH concentration in euthyroid subjects. Methods: Studies held on the Ovid MEDLINE database were searched and original articles published from 2000 to 2010 were included. The literature search was restricted to studies conducted in humans aged 18 years or older and written in English, Spanish, or Portuguese. Studies that evaluated the association between anthropometric measures and serum TSH within the normal range as the primary objective, as well as additional analysis, were included. Results: A total of 29 studies met the inclusion criteria. Of the 29 studies, 18 showed a positive relationship between measures of adiposity and serum TSH. Despite the plausibility of this association, only two studies reported longitudinal findings. The influence of smoking on the association between serum TSH and anthropometric measures was evaluated in only three studies and remains unclear. Conclusion: Thus, further longitudinal studies are needed to better understand the mechanisms by which TSH concentration might impact body weight.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between serum TSH concentration within the normal range and adiposity

Souza

Sichieri²

2011

European Journal of Endocrinology

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“…Many organs feel the inflammatory effects of leptin, but the disruption of control along with the inflammation is likely a unique condition. The dance continues in postmenopausal women as described by Teixeira et al (2009) where serum leptin is elevated in postmenopausal women with subclinical or overt hyperthyroidism. IL-6 is also seen as elevated in this population (Siemińska et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Merrill

2015

Journal of Theoretical Biology

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“…Indeed, positive correlations between serum TSH and blood pressure (35,36) and between TSH and serum lipids (2, 37, 38) have been demonstrated in several studies. In addition, a potential relationship between SCH and metabolic syndrome and a reduction in insulin sensitivity have also been proposed (39,40), and SCH also seems to be associated with additional CV risk factors. The results of this study are consistent with the findings of a recent publication (41) showing a higher CACS in male SCH patients.…”

Section: Discussionmentioning

confidence: 99%

Subclinical hypothyroidism represents an additional risk factor for coronary artery calcification, especially in subjects with intermediate and high cardiovascular risk scores

Silva¹,

Santos²,

Morais³

et al. 2014

European Journal of Endocrinology

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Objective: Several studies have suggested an association between subclinical hypothyroidism (SCH) and increased cardiovascular risk. The aim of this study was to evaluate the presence of coronary artery disease (CAD) in asymptomatic patients with SCH by measuring the coronary artery calcium score (CACS). Design: A total of 222 asymptomatic subjects (103 SCH and 119 euthyroid (EU)), who were between the ages of 35 and 65 years and had no previous history of CAD, were enrolled for this cross-sectional analysis. Methods: The criteria for SCH included a confirmed normal serum free thyroxine and high TSH levels. Lipid profile, Framingham risk score (FRS) and CACS analyses were performed for all subjects. Results: The SCH and EU groups were comparable with respect to age, gender, BMI and frequency of diabetes, systemic arterial hypertension, hypercholesterolaemia and smoking. There was no difference in the median CACS between the SCH and EU groups. However, in the subgroup of subjects with intermediate/high FRS (AR 10y R10%), CACS was higher in the SCH subjects compared with EU subjects (EU vs SCH, 0.0 (57.0) vs 23.0 (161.5); PZ0.045). Multivariate analysis revealed that the risk for CACS O100 was independently associated with male gender, age O55 years, and the presence of simultaneous SCH and AR 10y R10% (ORZ87.5 (CIZ2.1-3500); PZ0.001). Serum TSH was positively correlated with CACS, especially in intermediate/high FRS subjects (r s Z0.301, PZ0.045). Conclusions: It was demonstrated that SCH represents an additional risk factor for CAD, notably in intermediate and high FRS subjects.

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Serum Leptin in Overt and Subclinical Hypothyroidism: Effect of Levothyroxine Treatment and Relationship to Menopausal Status and Body Composition

Cited by 25 publications

References 26 publications

Association between serum TSH concentration within the normal range and adiposity

Association between serum TSH concentration within the normal range and adiposity

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Subclinical hypothyroidism represents an additional risk factor for coronary artery calcification, especially in subjects with intermediate and high cardiovascular risk scores

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