Serum leptin in diabetic nephropathy male patients from Gaza Strip

Yassin, Maged M.; AbuMustafa, Ayman M.; Yassin, Mohamed

doi:10.1016/j.dsx.2019.02.004

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…In agreement with the results of the present study, Cha et al [24] found that plasma leptin level is positively correlated with BMI, fasting plasma glucose HbA 1c and total cholesterol values in patients with T2DM. Yassin et al [25], who studied serum leptin level in patients with T2DM also found significant positive correlations between serum leptin and diabetes duration, cholesterol, triglycerides and LDL-C. Zulfania et al [26] in concordance with the results of the present study found that serum leptin concentration was significantly correlated with BMI, FPG and HbA 1c in patients with T2DM.…”

Section: Discussionsupporting

confidence: 90%

“…Cha et al [24] showed similar results as they found a significant positive correlation between serum leptin level and urinary albumin excretion, and significant negative correlation with creatinine clearance. Yassin et al [25] also showed a significant positive relation between serum leptin level and urinary albumin excretion and they concluded that serum leptin may be used as a marker of progression of diabetic kidney disease. On the other hand, Sari et al [28], who studied the relation between serum leptin level and diabetic complications in patients with T2DM, found no significant difference between patients with and without diabetic nephropathy, retinopathy or neuropathy.…”

Section: Discussionmentioning

confidence: 97%

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Serum leptin level and microvascular complications in type 2 diabetes

Aaty

Rezk

Megallaa

et al. 2020

Clinical Diabetology

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Background. Type 2 diabetes (T2DM) and its complications are highly prevalent in Egypt and are considered a major health problem. Insulin resistance arising from visceral obesity is the main pathological mechanism of T2DM. Leptin is an adipokine secreted from visceral adipose tissue and its level is proved to be higher in patients with T2DM, but its association with microvascular complications is not yet well-established, for this aim the present study was conducted. Methods. This cross-sectional study was conducted among 120 participants with T2DM recruited from the diabetes outpatient clinic of Alexandria Main University Hospital, Alexandria, Egypt. Each participant was subjected to full history taking, complete physical examination and laboratory investigations. Results. Serum leptin level was significantly positively correlated with diabetes duration, BMI, WC, systolic and diastolic blood pressure, FPG, HbA 1c , serum insulin level, HOMA-IR, total cholesterol, triglycerides and LDL-C. Regarding microvascular complications, serum leptin level was highly significantly positively correlated with UACR, peripheral neuropathy and retinopathy

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Section: Discussionsupporting

confidence: 90%